Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,680.00 | |
50 mg | 8-10 weeks | $ 2,190.00 | |
100 mg | 8-10 weeks | $ 3,100.00 |
Description | JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. |
Targets&IC50 | TrkA:261 nM , CSF1R:13 nM |
In vivo | JTE-952 treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model). |
Molecular Weight | 518.6 |
Formula | C30H34N2O6 |
CAS No. | 1255303-54-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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JTE-952 1255303-54-8 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor JTE 952 JTE952 inhibitor inhibit