amg — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T14217	AMG 579	AMG-579	PDE
	AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).		PDE
T6260	AMG-208	AMG 208	P450 , c-Met/HGFR
	AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.		P450 , c-Met/HGFR
T5479	AMG 333	AMG-333	TRP/TRPV Channel
	AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.		TRP/TRPV Channel
T6378	AMG-458	AMG 458	c-Met/HGFR
	AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.		c-Met/HGFR
T6380	AMG 900	AMG900,AMG-900	p38 MAPK , Tyrosine Kinases , Aurora Kinase
	AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.		p38 MAPK , Tyrosine Kinases , Aurora Kinase
T6379	AMG 517	AMG517,AMG-517	TRP/TRPV Channel
	AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV1.		TRP/TRPV Channel
TQ0055	AMG-3969		Glucokinase
	AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).		Glucokinase
T14212	AMG-1694		Glucokinase
	AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of...		Glucokinase
T14214	AMG 511		PI3K
	AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG...		PI3K
T29968	AMG-0347	UNII-CD7L9290QR	TRP/TRPV Channel
	AMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental s...		TRP/TRPV Channel
T10297L	AMG 487		CXCR
	AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.		CXCR
T6756	AMG 925		FLT , CDK
	AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.		FLT , CDK
T14211	AMG-009		Others
	AMG-009 is a prostaglandin D2 antagonist. For CRTH2 and DP receptors, the IC50s are 3 nM and 12 nM, respectively.		Others
T7123	AMG-47a		VEGFR , p38 MAPK , JAK , Src
	AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protei...		VEGFR , p38 MAPK , JAK , Src
T22258	(S)-AMG-510		Ras
	(S)-AMG-510 is an S-type compound of AMG-510, a potent covalent inhibitor of KRAS G12C with potential antitumor activity.		Ras
T3209	AMG-337	AMG337	c-Met/HGFR
	AMG-337 is an effective and highly specific ATP-competitive MET kinase inhibitor. In enzymatic assays, AMG-337(AMG337) inhibits MET kinase activity (IC50: < 5 nM).		c-Met/HGFR
TQ0020	AMG 837 calcium hydrate		GPR
	AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM. AMG 837 calcium hydrate also shows highly selective over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM).		GPR
T8684	Sotorasib	AMG-510	Ras
	Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib ...		Ras
T8409	SYN1143	RON-IN-1,AMG-1	c-Met/HGFR
	SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.		c-Met/HGFR
T29969	AMG-126737	105RSZ5CNS,AMG 126737,SCHEMBL7986111
	AMG-126737 is an effective human lung mast cell trypsin inhibitor with potential therapeutic effect in lung diseases.
T77491	Prezalumab	AMG 557	Others
	Prezalumab (AMG 557) is a human IgG2 monoclonal antibody against ICOSL and BAFF. Prezalumab can be used to study sjogren's syndrome cutaneous lupus erythematosus, psoriasis, systemic lupus erythematosus arthritis and sys...		Others
T76758	Rilotumumab	AMG 102	c-Met/HGFR
	Rilotumumab (AMG 102) is a monoclonal antibody targeting hepatocyte growth factor that inhibits HGF/ MET-driven signaling. Rilotumumab has antitumor effects and can be used to study castration-resistant prostate cancer (...		c-Met/HGFR
T14390	Azelaprag	AMG 986	Apelin receptor
	Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases.		Apelin receptor
T76810	Ganitumab	AMG 479	IGF-1R
	Ganitumab (AMG 479) is a highly potent monoclonal antibody to type 1 insulin-like growth factor receptor (IGF1R). Ganitumab is recognized to bind to IGF1R at low concentration with KD value of 0.22 nM. Ganitumab can inhi...		IGF-1R
T30142	ARRY-403	AMG-151,ARRY 403,ARRY403,ARRY-403,AMG151,AMG 151	Glucokinase
	ARRY-403 is a novel glucokinase activator that reduces fasting and postprandial blood glucose in patients with type 2 diabetes.		Glucokinase
T76874	Erenumab	AMG-334	CGRP Receptor
	Erenumab is a whole-human monoclonal antibody. Erenumab inhibits calcitonin gene-related peptide (CGRP) receptors. Erenumab can be used to prevent migraine attacks.		CGRP Receptor
T2406	Cinacalcet hydrochloride	AMG-073 HCl,Cinacalcet HCl,AMG-073 hydrochloride,Cinacalcet	CaSR
	Cinacalcet hydrochloride (AMG-073 hydrochloride) is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces para...		CaSR
T17232	Vidupiprant	AMG 853	Prostaglandin Receptor
	Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.		Prostaglandin Receptor
T11762L	Kira8	AMG-18	IRE1
	Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM).		IRE1
T2288L	Motesanib Diphosphate	Motesanib,AMG 706	VEGFR , c-Kit
	Motesanib Diphosphate (AMG 706) is the orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity.		VEGFR , c-Kit
T37732	AMG 21629
	Potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors and acid-induced Ca2+ uptake, respectively). Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks cap...
T8403	Cinacalcet	AMG 073	CaSR
	Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist, treatment of cardiovascular disease .		CaSR
T29973	AMG-628	AMG628,AMG 628,CHEMBL226574,UNII-28J966TN3X
	AMG-628 is an effective and ATP-competitive RAF kinase inhibitor. AMG-628 has been shown to inhibit growth and induce cell cycle arrest and apoptosis in colon and melanoma cell lines with B-RAFV600E mutations.
T22259	AMG-Tie2-1	AMG-Tie2	Others
	AMG-Tie2-1 is a dual inhibitor of VEGF receptor 2 (VEGFR2) and tunica interna endothelial cell kinase 2 (Tie2).		Others
T29976	AMG-8562	UNII-X2S52Z1DY9,AMG 8562,AMG8562,SCHEMBL14993014,X2S52Z1DY9
	AMG-8562 is a modulator of TRPV1 .
T2288	Motesanib	AMG 706	VEGFR , c-Kit
	Motesanib (AMG 706) is an orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-deriv...		VEGFR , c-Kit
T29970	AMG-222	AMG 222,ALS-2-0426 free base,ALS-2-0426,ALS-20426
	AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes.
T76796	Patritumab	U3-1287,AMG-888	ERK , EGFR , Akt , HER
	Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritumab promotes apoptosis and inhibits proliferation in non-sm...		ERK , EGFR , Akt , HER
T76892	Ordesekimab	AMG 714,PRV-015	IL Receptor
	Ordesekimab (AMG 714) is a human IgG1 κ-anti-IL-15 (Interleukin Related) monoclonal antibody. Ordesekimab binds competitively to IL-15, inhibiting the interaction of IL-15 with the common gamma chain of the IL-2Rβ and IL...		IL Receptor
T68408	AMG-1
	AMG-1 is a specific CRAC channel inhibitor. AMG-1 blocks the function of effector T cells, but not regulatory T cells in vitro and it attenuates the progression and severity of EAE in vivo.
T76787	Conatumumab	TRAIL-R2 mAb,AMG 655	TNF
	Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 (DR5, TRAILR2) at Kd 1 nM for long DR5 and Kd 0.8 nM for short DR5. Conatumumab induces apoptosis in a variety of tumor types throug...		TNF
T28225	Obicetrapib	TA8995,AMG899,Obicetrapib (free base),AMG 899,AMG-899,Obicetrapib,TA-8995	CETP
	Obicetrapib (AMG-899) is an inhibitor of cholesteryl ester transfer protein.		CETP
T10299	AMG PERK 44		PERK , Autophagy
	AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) that induces autophagy.AMG PERK 44 inhibits GCN2 (IC50: 7300 nM) and B-Raf (IC50 >1000 nM) and can be used in the study of cancer.		PERK , Autophagy
T14216	AMG 837		Others
	AMG 837 is a partial GPR40 agonist with an EC50 value of 13 nM, showcasing 85% of the maximal activity displayed by DHA in standard assay conditions, indicating its high potency and selectivity in vitro. This compound ex...		Others
T23719	AMG-076
	AMG-076 is an antagonist of melanin-concentrating hormone receptor 1. It also reduced hERG inhibition.
TQ0127	Navtemadlin	AMG232,CS-1300	Mdm2 , E1/E2/E3 Enzyme
	Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.		Mdm2 , E1/E2/E3 Enzyme
T22477	(±)-AMG 487		Others
	AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36 nM, respectively).		Others
T69740	AMG-315
	AMG-315 is a Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. AMG-315 is a chiral arachidonoyl ethanolamide (AEA) analogue or (13S,1′R)-dimethylanandamide. AMG-315 is a high affinity ligand for the ...
T77359	Tezepelumab	Tezepelumab-ekko,MEDI 19929,AMG 157	Others
	Tezepelumab (AMG 157) is a humanized monoclonal antibody (IgG2λ) targeting TSLP that prevents TSLP from interacting with its heterodimer receptor. Tezepelumab can be used to study advanced asthma disease.		Others
T10298L	AMG-548		p38 MAPK
	AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ and is also extremely potent in the inhibition of whole b...		p38 MAPK

Compounds

AMG 579

T14217

Target: P450, c-Met/HGFR

AMG 333

T5479

Synonym: AMG-333

Target: TRP/TRPV Channel

Synonym: AMG900,AMG-900

Target: p38 MAPK, Tyrosine Kinases, Aurora Kinase

AMG 517

T6379

Synonym: AMG517,AMG-517

Target: TRP/TRPV Channel

Synonym: UNII-CD7L9290QR

Target: TRP/TRPV Channel

Target: VEGFR, p38 MAPK, JAK, Src

AMG 837 calcium hydrate

Synonym: RON-IN-1,AMG-1

Target: c-Met/HGFR

AMG-126737

T29969

Synonym: 105RSZ5CNS,AMG 126737,SCHEMBL7986111

Target: Apelin receptor

Synonym: AMG-151,ARRY 403,ARRY403,ARRY-403,AMG151,AMG 151

Target: CGRP Receptor

Cinacalcet hydrochloride

T2406

Synonym: AMG-073 HCl,Cinacalcet HCl,AMG-073 hydrochloride,Cinacalcet

Target: Prostaglandin Receptor

Motesanib Diphosphate

T2288L

Synonym: Motesanib,AMG 706

Synonym: AMG628,AMG 628,CHEMBL226574,UNII-28J966TN3X

Synonym: UNII-X2S52Z1DY9,AMG 8562,AMG8562,SCHEMBL14993014,X2S52Z1DY9

Synonym: AMG 222,ALS-2-0426 free base,ALS-2-0426,ALS-20426

Target:

Patritumab

T76796

Synonym: U3-1287,AMG-888

Target: ERK, EGFR, Akt, HER

Ordesekimab

T76892

Synonym: AMG 714,PRV-015

Synonym: TRAIL-R2 mAb,AMG 655

Target: TNF

Obicetrapib

T28225

Synonym: TA8995,AMG899,Obicetrapib (free base),AMG 899,AMG-899,Obicetrapib,TA-8995

Target: PERK, Autophagy

Synonym: AMG232,CS-1300

Target: Mdm2, E1/E2/E3 Enzyme

Synonym: Tezepelumab-ekko,MEDI 19929,AMG 157

Cat No.	Product Name	Species	Expression System
TMPH-00925	AMELX Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	AMELX Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-00924	AMELX Protein, Human, Recombinant (His & Myc)	Human	Baculovirus Insect Cells
	AMELX Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus.

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Recombinant Proteins

Compounds

Recombinant Proteins