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Azelaprag

Name: Azelaprag
Brand: TargetMol
SKU: T14390
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14390Cas No. 2049980-18-7

Alias AMG 986

Azelaprag (Example 263.0) is a candidate active molecule (EC50= 0.32 nM) for an apelin receptor agonist. Azelaprag can be used to treat nervous system diseases, cardiovascular diseases.

Azelaprag

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Purity: 99.67%

Catalog No. T14390Alias AMG 986Cas No. 2049980-18-7

Azelaprag (Example 263.0) is a candidate active molecule (EC50= 0.32 nM) for an apelin receptor agonist. Azelaprag can be used to treat nervous system diseases, cardiovascular diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$107	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$413	In Stock	In Stock
25 mg	$629	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$336	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.67%

ee:100%

Appearance:Solid

Color:White

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COA HNMR CSFC LCMS

Product Introduction

Bioactivity

Description	Azelaprag (Example 263.0) is a candidate active molecule (EC50= 0.32 nM) for an apelin receptor agonist. Azelaprag can be used to treat nervous system diseases, cardiovascular diseases.
Targets&IC50	apelin receptor:0.32 nM (EC50), RAGE:12.7 ± 7.6 nM (kd)
In vivo	METHODS: To investigate the effect of Azelaprag on cardiac function, Azelaprag (1mg/kg/min) was infused intravenously at an acute time point in a rat model of impaired metabolic function. RESULTS: Azelaprag increased cardiac reserve during Dobutamine challenge in a metabolically impaired rat model. [1]
Synonyms	AMG 986

Chemical Properties

Molecular Weight	523.61
Formula	C₂₅H₂₉N₇O₄S
Cas No.	2049980-18-7
Smiles	N(S([C@H]([C@H](C)C=1N=CC(C)=CN1)C)(=O)=O)C=2N(C(=NN2)C=3C=C(C)C=NC3)C4=C(OC)C=CC=C4OC
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 69.3 mg/mL (132.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9098 mL	9.5491 mL	19.0982 mL	95.4909 mL
5 mM	0.3820 mL	1.9098 mL	3.8196 mL	19.0982 mL
10 mM	0.1910 mL	0.9549 mL	1.9098 mL	9.5491 mL
20 mM	0.0955 mL	0.4775 mL	0.9549 mL	4.7745 mL
50 mM	0.0382 mL	0.1910 mL	0.3820 mL	1.9098 mL
100 mM	0.0191 mL	0.0955 mL	0.1910 mL	0.9549 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc