Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 1,190.00 | |
50 mg | In stock | $ 2,800.00 |
Description | Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases. |
Targets&IC50 | RAGE:12.7 ± 7.6 nM (kd) |
In vivo | In the transgenic Alzheimer's disease animal model (tgAPPSwedish/London), azeliragon (5 mg/day) reduces Aβ plaque deposition, decreases overall Aβ burden while increasing Aβ levels in plasma, lowers sAPPβ and increases sAPPα levels, reduces inflammatory cytokines, slows cognitive decline, and improves cerebral blood flow.[1] |
Synonyms | AMG 986 |
Molecular Weight | 523.61 |
Formula | C25H29N7O4S |
CAS No. | 2049980-18-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Azelaprag 2049980-18-7 GPCR/G Protein Apelin receptor AMG986 AMG-986 AMG 986 inhibitor inhibit