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Trovafloxacin mesylate

Catalog No. T13231L CAS 147059-75-4

Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the pannexin 1 channel (PANX1, IC50 = 4 μM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Trovafloxacin mesylate Chemical Structure

Trovafloxacin mesylate, CAS 147059-75-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 385.00
100 mg	In stock	$ 578.00
1 mL * 10 mM (in DMSO)	In stock	$ 100.00

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Purity: 99.12%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the pannexin 1 channel (PANX1, IC50 = 4 μM).
Targets&IC50	PANX1:4 μM
In vitro	Trovafloxacin mesylate is an inhibitor of TO-PRO-3 uptake by apoptotic cells and inhibits ATP release from apoptotic cells. Trovafloxacin mesylate does not inhibit caspase 3/7 activation, or caspase-mediated PANX1 cleavage during apoptosis[1]. Trovafloxacin mesylate is equally active against both penicillin-susceptible and -resistant pneumococci, with MICs of 0.06-0.25 mg/mL reported for more than 700 isolates. The MICs of Trovafloxacin mesylate at which 90% of isolates are inhibited for 55 isolates of pneumococci is 0.125 μg/mL[2]. Trovafloxacin mesylate prolongs TNF-induced activation of MAPKs and IKKα/β activation in HepG2 cells. Trovafloxacin mesylate (20 µM; 24 hours) and tumor necrosis factor (TNF; 4 ng/mL) incubation induces apoptosis and increases leakage of lactate dehydrogenase (LDH). Trovafloxacin mesylate (20 µM; 24 hours) and TNF (4 ng/mL) incubation increases expression of early NF-κB-related factors A20 and IκBα[3].

Molecular Weight	512.46
Formula	C21H19F3N4O6S
CAS No.	147059-75-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (234.16 mM), Sonification and heating to 60℃ are recommended.

H2O: 18 mg/mL (35.12 mM), Sonification is recommended.

References and Literature

1. Giustarini G, et al. The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. 3. Gootz TD, et al. Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob Agents Chemother. 1996 Dec;40(12):2691-7. 4. Poon IK, et al. Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature. 2014 Mar 20;507(7492):329-34.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Approved Drug Library EMA Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Compound Library DNA Damage & Repair Compound Library Approved Drug Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Trovafloxacin mesylate 147059-75-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others DNA/RNA Synthesis Antibacterial Topoisomerase topoisomerase-IV TNF gyrase Bacterial hepatotoxicity LPS Trovafloxacin broad-spectrum Antibiotic DNA Inhibitor PANX1 pneumococci inhibit pro-inflammatory NF-κB Trovafloxacin Mesylate inhibitor

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