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Trovafloxacin mesylate

Trovafloxacin mesylate
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Trovafloxacin mesylate

Catalog No. T13231LCas No. 147059-75-4
Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the pannexin 1 channel (PANX1, IC50 = 4 μM).
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Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
5 mg$72In Stock
10 mg$122In Stock
25 mg$197In Stock
50 mg$385In Stock
100 mg$578In Stock
1 mL x 10 mM (in DMSO)$100In Stock
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Product Introduction

Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the pannexin 1 channel (PANX1, IC50 = 4 μM).
In vitro
Trovafloxacin mesylate is an inhibitor of TO-PRO-3 uptake by apoptotic cells and inhibits ATP release from apoptotic cells. Trovafloxacin mesylate does not inhibit caspase 3/7 activation, or caspase-mediated PANX1 cleavage during apoptosis[1]. Trovafloxacin mesylate is equally active against both penicillin-susceptible and -resistant pneumococci, with MICs of 0.06-0.25 mg/mL reported for more than 700 isolates. The MICs of Trovafloxacin mesylate at which 90% of isolates are inhibited for 55 isolates of pneumococci is 0.125 μg/mL[2]. Trovafloxacin mesylate prolongs TNF-induced activation of MAPKs and IKKα/β activation in HepG2 cells. Trovafloxacin mesylate (20 µM; 24 hours) and tumor necrosis factor (TNF; 4 ng/mL) incubation induces apoptosis and increases leakage of lactate dehydrogenase (LDH). Trovafloxacin mesylate (20 µM; 24 hours) and TNF (4 ng/mL) incubation increases expression of early NF-κB-related factors A20 and IκBα[3].
Chemical Properties
Molecular Weight512.46
Cas No.147059-75-4
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 120 mg/mL (234.16 mM)
H2O: 18 mg/mL (35.12 mM)
Solution Preparation Table
1 mM1.9514 mL9.7569 mL19.5137 mL97.5686 mL
5 mM0.3903 mL1.9514 mL3.9027 mL19.5137 mL
10 mM0.1951 mL0.9757 mL1.9514 mL9.7569 mL
20 mM0.0976 mL0.4878 mL0.9757 mL4.8784 mL
50 mM0.0390 mL0.1951 mL0.3903 mL1.9514 mL
100 mM0.0195 mL0.0976 mL0.1951 mL0.9757 mL


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