Powder: -20°C for 3 years
In solvent: -80°C for 2 years
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation.
Description | AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. |
Targets&IC50 | GK-GKRP:7 nM |
In vitro | AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50 of 0.020?μM in the presence of GKRP[1]. |
Molecular Weight | 533.63 |
Formula | C23H30F3N3O4S2 |
CAS No. | 1361217-07-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AMG-1694 1361217-07-3 代谢 Glucokinase AMG1694 AMG 1694 Inhibitor inhibitor inhibit