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AMG-1694

Catalog No. T14212 CAS 1361217-07-3

AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation.

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AMG-1694, CAS 1361217-07-3

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Purity: 98%

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Description	AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation.
Targets&IC50	GK-GKRP:7 nM
In vitro	AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50 of 0.020?μM in the presence of GKRP[1].

Molecular Weight	533.63
Formula	C23H30F3N3O4S2
CAS No.	1361217-07-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lloyd DJ, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504(7480):437-40.

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Keywords

AMG-1694 1361217-07-3 代谢 Glucokinase AMG1694 AMG 1694 Inhibitor inhibitor inhibit

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