Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 380.00 | |
5 mg | In stock | $ 882.00 | |
10 mg | In stock | $ 1,220.00 | |
25 mg | In stock | $ 1,760.00 | |
50 mg | In stock | $ 2,180.00 | |
100 mg | In stock | $ 2,800.00 |
Description | AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. |
Targets&IC50 | GK-GKRP:7 nM, GK:0.02 μM(EC50) |
In vitro | AMG-1694 demonstrates high efficacy in reinstating the enzymatic activity of GK in the presence of GKRP with an EC50 of 0.020 μM.[1] |
Molecular Weight | 533.63 |
Formula | C23H30F3N3O4S2 |
CAS No. | 1361217-07-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AMG-1694 1361217-07-3 Metabolism Glucokinase AMG 1694 AMG1694 inhibitor inhibit