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Vidupiprant

Catalog No. T17232 CAS 1169483-24-2

Synonyms: AMG 853

Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.

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Vidupiprant, CAS 1169483-24-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 61.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 229.00
25 mg	In stock	$ 417.00
50 mg	In stock	$ 622.00
100 mg	In stock	$ 885.00
500 mg	In stock	$ 1,780.00
1 mL * 10 mM (in DMSO)	In stock	$ 198.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.
In vitro	Vidupiprant inhibits prostaglandin D2-induced cAMP response in platelets in 80% human whole blood with a Kb of 4.7 nM. Vidupiprant inhibits the prostaglandin D2 -induced down-modulation of CRTH2 on CD16 negative granulocytes in human whole blood with a Kb of 0.2 nM. Vidupiprant demonstrates antagonist activity in an aequorin assay using CRTH2-transfected HEK 293 cells and an eosinophil shape change assay[1].
In vivo	In a guinea pig model of PGD2-induced airway constriction, airway resistance is measured in response to PGD2 challenge. Vidupiprant has a Kb of 5 nM[1].

Synonyms	AMG 853
Molecular Weight	609.49
Formula	C28H27Cl2FN2O6S
CAS No.	1169483-24-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (155.87 mM), Sonication is recommended.

References and Literature

1. Liu J, et al. Discovery of AMG 853, a CRTH2 and DP Dual Antagonist. ACS Med Chem Lett. 2011 Mar 2;2(5):326-30.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Drug Library GPCR Compound Library Bioactive Compounds Library Max Pediatric Drug Library Clinical Compound Library Bioactive Compound Library

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Keywords

Vidupiprant 1169483-24-2 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor Inhibitor orally AMG-853 acid cAMP phenylacetic asthma PGD2 AMG 009 AMG853 inhibit CRTH2 AMG 853 inhibitor

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