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Cinacalcet

Name: Cinacalcet
Brand: TargetMol
SKU: T8403
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8403Cas No. 226256-56-0

Alias AMG 073

Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist used in the treatment of cardiovascular disease.

Cinacalcet

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Purity: 99.48%

Catalog No. T8403Alias AMG 073Cas No. 226256-56-0

Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist used in the treatment of cardiovascular disease.

Pack Size	Price	Availability
10 mg	$43	In Stock
25 mg	$64	In Stock
50 mg	$80	In Stock
100 mg	$147	In Stock
500 mg	$369	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock

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Batch Information

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Purity:99.48%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist used in the treatment of cardiovascular disease.
Synonyms	AMG 073

Chemical Properties

Molecular Weight	357.41
Formula	C₂₂H₂₂F₃N
Cas No.	226256-56-0
Smiles	[C@@H](NCCCC1=CC(C(F)(F)F)=CC=C1)(C)C=2C3=C(C=CC2)C=CC=C3
Relative Density.	1.154 g/cm3
Color	Transparent
Appearance	Liquid

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (279.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7979 mL	13.9895 mL	27.9791 mL	139.8954 mL
5 mM	0.5596 mL	2.7979 mL	5.5958 mL	27.9791 mL
10 mM	0.2798 mL	1.3990 mL	2.7979 mL	13.9895 mL
20 mM	0.1399 mL	0.6995 mL	1.3990 mL	6.9948 mL
50 mM	0.0560 mL	0.2798 mL	0.5596 mL	2.7979 mL
100 mM	0.0280 mL	0.1399 mL	0.2798 mL	1.3990 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc