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Search Result

Search Results for " microtubule/tubulin "

Targets

Microtubule Associated

113

Compounds

34

Natural Products

7

Recombinant Proteins

2

Libraries

Cat No. Product Name Synonyms Targets
T15236 Entasobulin Microtubule Associated
Entasobulin is an inhibitor of β-tubulin polymerization. It has a potential anticancer activity.
T60026 KIF18A-IN-2 Microtubule Associated
KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.
T9504 MAP4343 Microtubule Associated
Map4343 is a 3-methyl ether derivative of pregnenolone. Map4343 binds to microtubule associated protein 2 (MAP2) in vitro and stimulates tubulin polymerization, resulting in enhanced neurite extension and protection of n...
T9812 Tubulin inhibitor 24 Microtubule Associated
Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.
T13224 Tubulin inhibitor 6 iHAP1 Microtubule Associated
Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.
T14349 Auristatin F Microtubule Associated
Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.
T39994 Sovilnesib Microtubule Associated
Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research.
T14348 Auristatin E Microtubule Associated
Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in an...
T21632 Myoseverin Others , Microtubule Associated
Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and str...
T14694 BNC105 Microtubule Associated
BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.
T7800 TN-16 Microtubule Associated
TN-16 is a microtubule polymerization inhibitor (IC50 :0.4-1.7 μM)
T4077 PE859 Beta Amyloid , Gamma-secretase , Microtubule Associated
PE859 is a potent inhibitor of both tau and Aβ aggregation.
T5699 SSE15206 Apoptosis , Microtubule Associated
SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
T1753 D-64131 Microtubule Associated
D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.
T22661 CHM-1 Apoptosis , Others , Microtubule Associated
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.
T9595 LP-261 Microtubule Associated
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.
T2511 Plinabulin NPI-2358 Microtubule Associated
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, the...
T13278 Valecobulin hydrochloride CKD-516 hydrochloride Microtubule Associated
Valecobulin hydrochloride (CKD-516 hydrochloride) is a potent inhibitor of β-tubulin polymerization. Valecobulin hydrochloride is a valine prodrug and a vascular disrupting agent.
T6071 Parbendazole SKF 29044 Microtubule Associated , Parasite
Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatment of nematode infestations.
T2090 Lexibulin CYT-997 Apoptosis , Reactive Oxygen Species , Microtubule Associated
Lexibulin (CYT-997)(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this...
T4029 BTB-1 BTB 1,NSC156750 Microtubule Associated
BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
T41248 Thiocolchicine Microtubule Associated
Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.
T4232 VCMMAE mc-vc-PAB-MMAE Microtubule Associated
VCMMAE (mc-vc-PAB-MMAE) is a drug-linker conjugate for ADC with potent antitumor activity.
T8342 BRD9876 Others , Kinesin , Microtubule Associated
BRD9876 is a selective inhibitor of MM1S growth.
T10460 Batabulin T138067 Apoptosis , Microtubule Associated
Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce...
T15141 DM4 Ravtansine Others , Microtubule Associated
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
T14350 Soblidotin Auristatin PE,TZT-1027 Microtubule Associated
Soblidotin (TZT-1027) (Auristatin PE) is an inhibitor of tubulin polymerization. It is also a novel synthetic Dolastatin 10 derivative.
T6345 Tirbanibulin KX2-391,KX-01 Microtubule Associated , Src
Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of colon, pancreatic, prostate and breast cancer. It is a substrate-targeted kinase inhibit...
T1758 ABT-751 E7010 Microtubule Associated , Autophagy
ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
T1992 Mertansine DM1,Maytansinoid DM1 Microtubule Associated
Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4...
T50005 Sertaconazole Antifungal
Sertaconazole is a broad-spectrum antifungal.
T3256 MMAF MonoMethyl auristatin F Others , Microtubule Associated
MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
T0838 Triclabendazole CGA89317 Microtubule Associated , Parasite
Triclabendazole (CGA89317) has been used in trials studying Parasitic Disease.
T0009 Flubendazole Flumoxanal,Flumoxane,NSC 313680,Fluvermal Apoptosis , Microtubule Associated , Parasite
Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
T15012 Crolibulin EPC2407 Microtubule Associated
Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.
T2060 ELR510444 LR-510444,LR510444,LR 510444 Apoptosis , Microtubule Associated
ELR510444 (LR510444) is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpress...
T6075 Epothilone B Patupilone,EPO 906 Apoptosis , Microtubule Associated , Antibiotic , Antifungal
Epothilone B (EPO 906) is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditi...
T2802 Nocodazole R17934,Oncodazole Apoptosis , Microtubule Associated , Bcr-Abl , Autophagy , CRISPR/Cas9
Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis.
T3330L Cis-trismethoxy Resveratrol (Z)-3,5,4'-Trimethoxystilbene Microtubule Associated
cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) inhibits tubulin polymerization (IC50 = 4 μM) and has anti-mitotic effects.
T6897 Monomethyl auristatin E Vedotin,MMAE Apoptosis , Microtubule Associated
Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.
T21408 DM1-SMe DM1-SSMe Microtubule Associated
DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell ...
T4451 Estramustine phosphate sodium Ro 21-8837/001,Estramustine phosphate disodium Apoptosis , Microtubule Associated
Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
T15675 Tirbanibulin Mesylate KX2-391 Mesylate,KX01 Mesylate Microtubule Associated , Src
Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
T18312 Mc-MMAE Maleimidocaproyl-monomethylauristatin E Microtubule Associated
Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.
T9831 MKC-1 Ro-31-7453 Apoptosis , Akt , Microtubule Associated , mTOR
MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the format...
T6864 Ixabepilone BMS 247550,Ixempra,Azaepothilone B,BMS 247550-1 Apoptosis , Microtubule Associated
Ixabepilone (Azaepothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell ...
T1910 Ansamitocin P 3' Maytansinol butyrate,Ansamitocin P-3,Antibiotic C 15003P3' Microtubule Associated
Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.
T20681 Estramustine NSC-89201,NSC 89201,LEO 275,LEO275,NSC89201,LEO-275 Microtubule Associated
Estramustine (LEO-275) is a nitrogen mustard linked to estradiol, usually as phosphate. Estramustine has been used to treat prostatic neoplasms; also has radiation protective properties. Estramustine is selectively taken...
T13687 Eribulin mesylate B1939 mesylate,ER-086526 mesylate,E7389 mesylate Apoptosis , Others , Microtubule Associated
Eribulin mesylate (E7389 mesylate) (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is...
T4677 MMAD Monomethylauristatin D,Demethyldolastatin 10,Monomethyl Dolastatin 10 Microtubule Associated
MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).

Compounds

Entasobulin
T15236
Synonym:
Target: Microtubule Associated
KIF18A-IN-2
T60026
Synonym:
Target: Microtubule Associated
MAP4343
T9504
Synonym:
Target: Microtubule Associated
Tubulin inhibitor 24
T9812
Synonym:
Target: Microtubule Associated
Tubulin inhibitor 6
T13224
Synonym: iHAP1
Target: Microtubule Associated
Auristatin F
T14349
Synonym:
Target: Microtubule Associated
Sovilnesib
T39994
Synonym:
Target: Microtubule Associated
Auristatin E
T14348
Synonym:
Target: Microtubule Associated
Myoseverin
T21632
Synonym:
Target: Others, Microtubule Associated
BNC105
T14694
Synonym:
Target: Microtubule Associated
TN-16
T7800
Synonym:
Target: Microtubule Associated
PE859
T4077
Synonym:
Target: Beta Amyloid, Gamma-secretase, Microtubule Associated
SSE15206
T5699
Synonym:
Target: Apoptosis, Microtubule Associated
D-64131
T1753
Synonym:
Target: Microtubule Associated
CHM-1
T22661
Synonym:
Target: Apoptosis, Others, Microtubule Associated
LP-261
T9595
Synonym:
Target: Microtubule Associated
Plinabulin
T2511
Synonym: NPI-2358
Target: Microtubule Associated
Valecobulin hydrochloride
T13278
Synonym: CKD-516 hydrochloride
Target: Microtubule Associated
Parbendazole
T6071
Synonym: SKF 29044
Target: Microtubule Associated, Parasite
Lexibulin
T2090
Synonym: CYT-997
Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated
BTB-1
T4029
Synonym: BTB 1,NSC156750
Target: Microtubule Associated
Thiocolchicine
T41248
Synonym:
Target: Microtubule Associated
VCMMAE
T4232
Synonym: mc-vc-PAB-MMAE
Target: Microtubule Associated
BRD9876
T8342
Synonym:
Target: Others, Kinesin, Microtubule Associated
Batabulin
T10460
Synonym: T138067
Target: Apoptosis, Microtubule Associated
DM4
T15141
Synonym: Ravtansine
Target: Others, Microtubule Associated
Soblidotin
T14350
Synonym: Auristatin PE,TZT-1027
Target: Microtubule Associated
Tirbanibulin
T6345
Synonym: KX2-391,KX-01
Target: Microtubule Associated, Src
ABT-751
T1758
Synonym: E7010
Target: Microtubule Associated, Autophagy
Mertansine
T1992
Synonym: DM1,Maytansinoid DM1
Target: Microtubule Associated
Sertaconazole
T50005
Synonym:
Target: Antifungal
MMAF
T3256
Synonym: MonoMethyl auristatin F
Target: Others, Microtubule Associated
Triclabendazole
T0838
Synonym: CGA89317
Target: Microtubule Associated, Parasite
Flubendazole
T0009
Synonym: Flumoxanal,Flumoxane,NSC 313680,Fluvermal
Target: Apoptosis, Microtubule Associated, Parasite
Crolibulin
T15012
Synonym: EPC2407
Target: Microtubule Associated
ELR510444
T2060
Synonym: LR-510444,LR510444,LR 510444
Target: Apoptosis, Microtubule Associated
Epothilone B
T6075
Synonym: Patupilone,EPO 906
Target: Apoptosis, Microtubule Associated, Antibiotic, Antifungal
Nocodazole
T2802
Synonym: R17934,Oncodazole
Target: Apoptosis, Microtubule Associated, Bcr-Abl, Autophagy, CRISPR/Cas9
cis-trismethoxy Resveratrol
T3330L
Synonym: (Z)-3,5,4'-Trimethoxystilbene
Target: Microtubule Associated
Monomethyl auristatin E
T6897
Synonym: Vedotin,MMAE
Target: Apoptosis, Microtubule Associated
DM1-SMe
T21408
Synonym: DM1-SSMe
Target: Microtubule Associated
Estramustine phosphate sodium
T4451
Synonym: Ro 21-8837/001,Estramustine phosphate disodium
Target: Apoptosis, Microtubule Associated
Tirbanibulin Mesylate
T15675
Synonym: KX2-391 Mesylate,KX01 Mesylate
Target: Microtubule Associated, Src
Mc-MMAE
T18312
Synonym: Maleimidocaproyl-monomethylauristatin E
Target: Microtubule Associated
MKC-1
T9831
Synonym: Ro-31-7453
Target: Apoptosis, Akt, Microtubule Associated, mTOR
Ixabepilone
T6864
Synonym: BMS 247550,Ixempra,Azaepothilone B,BMS 247550-1
Target: Apoptosis, Microtubule Associated
Ansamitocin P 3'
T1910
Synonym: Maytansinol butyrate,Ansamitocin P-3,Antibiotic C 15003P3'
Target: Microtubule Associated
Estramustine
T20681
Synonym: NSC-89201,NSC 89201,LEO 275,LEO275,NSC89201,LEO-275
Target: Microtubule Associated
Eribulin mesylate
T13687
Synonym: B1939 mesylate,ER-086526 mesylate,E7389 mesylate
Target: Apoptosis, Others, Microtubule Associated
MMAD
T4677
Synonym: Monomethylauristatin D,Demethyldolastatin 10,Monomethyl Dolastatin 10
Target: Microtubule Associated
1 2 3
Cat No. Product Name Synonyms Targets
T36850 Curvulin Microtubule Associated
Curvulin is the active metabolite isolated from Paraphoma sp. VIZR 1.46. Curvularin inhibits iNOS expression and microtubule assembly.
T2773 Vindoline Microtubule Associated
Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly.
T8188 Podophyllotoxone Others , Microtubule Associated
Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.
TN2190 Scoulerine Apoptosis , Beta-Secretase , BACE , Parasite
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
T3S0209 Vincristine ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hemato...
T1121 Podofilox Podophyllotoxin,(+)-Shikonin Microtubule Associated , Topoisomerase
Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irrit...
TN2256 Taccalonolide B Microtubule Associated
Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM.
TN1087 Deoxypodophyllotoxin Apoptosis , Microtubule Associated , Autophagy
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.
TN2254 Taccalonolide A Apoptosis , Microtubule Associated
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these ...
T6490 Epothilone A epothile,Epo A Apoptosis , Microtubule Associated
Epothilone A (Epo A) is a microtubule-stabilizing agent with EC0.01 of 2 μM.
T21351 Maytansine NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine Microtubule Associated , Antibiotic
Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
T2217 Cephalomannine Baccatin III Microtubule Associated
Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.
T0320 Colchicine Colcin,Colchineos,Colchisol Apoptosis , Microtubule Associated , Autophagy
Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding to microtubule proteins. Colchicine can be used in the treatment of...
T0968 Paclitaxel Taxol,NSC 125973 Apoptosis , Microtubule Associated , Autophagy
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
T16016 Maytansinol Ansamitocin P-0 Apoptosis , Microtubule Associated
Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro.
T3S2372 7-epi-Taxol 7-Epitaxol,7-epi-Paclitaxel Others , Microtubule Associated
1. 7-epi-Taxol (7-Epitaxol) is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.
T1668 Vinblastine sulfate NSC49842,Vincaleukoblastine sulfate salt Microtubule Associated , AChR , Autophagy
Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
T1034 Docetaxel NSC 628503,RP-56976 Apoptosis , Microtubule Associated , Endogenous Metabolite
Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM). Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing,...
T1270 Vincristine sulfate Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate Apoptosis , Microtubule Associated
Vincristine sulfate (Leurocristine sulfate) binds irreversibly to microtubules and spindle proteins in S phase and interferes the formation of the mitotic spindle.
T19720 Colcemid C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine Microtubule Associated
Colcemid (NSC-3096) is an inhibitor of microtubule polymerization. It used to study embryonic cloning.
T6272 Fosbretabulin Disodium Combretastatin A4 Phosphate,CA 4DP,CA 4P,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Apoptosis , Microtubule Associated
Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibit...
TP1180 Dolastatin 10 NSC 376128,DLS 10 Microtubule Associated
Dolastatin 10 (DLS 10) is a powerful peptide with antimitotic properties, effectively inhibiting tubulin polymerization.
T6212 Combretastatin A4 CA4,CRC 87-09 Microtubule Associated
Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
T22455 Vindesine sulfate DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS Others
Vindesine sulfate (Desacetyl Vinblastine amide) is a vinca alkaloid which is a synthetic derivative of vinblastine, binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule...
T2220 2-Methoxyestradiol NSC-659853,2-MeOE2,2-ME2 Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T0186 Docetaxel trihydrate RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate Apoptosis , BCL , Microtubule Associated
Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor i...
T1152 Albendazole SKF-62979 HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
T2937 4'-Demethylepipodophyllotoxin 4'-DMEP,4-Demethylepipodophyllotoxin,DMEP,4'-O-demethylepipodophyllotoxin Microtubule Associated
4'-Demethylepipodophyllotoxin (DMEP) is a potent inhibitor of microtubule assembly.
T2543 Cabazitaxel XRP6258,RPR-116258A,TXD 258,taxoid XRP6258 Microtubule Associated , Autophagy
Cabazitaxel (taxoid XRP6258) is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.
T5165 10-Deacetyltaxol 10-DAT,10-Desacetyl Paclitaxel,Deacetyltaxol,10-deacetyl-paclitaxel,Deacetyl Paclitaxel Others , Microtubule Associated
10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks.
T6213 Vinorelbine ditartrate Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate Microtubule Associated , Autophagy
Vinorelbine ditartrate (KW-2307), a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
T5749 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,10-Deacetylpaclitaxel 7-Xyloside Others , Microtubule Associated
10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer.
T22262 Ansamitocin p-3 Maytansinol isobutyrate,Antibiotic C 15003P3,NSC292222 Microtubule Associated
Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization.
T75521 PM050489
PM050489, a potent polyketone inhibitor of Microtubule/Tubulin isolated from the Madagascan sponge Lithoplocamia lithistoides, effectively inhibits mitosis with an IC 50 value of 26.4 nM. This compound exhibits antitumor...

Natural Products

Curvulin
T36850
Synonym:
Target: Microtubule Associated
Vindoline
T2773
Synonym:
Target: Microtubule Associated
Podophyllotoxone
T8188
Synonym:
Target: Others, Microtubule Associated
Scoulerine
TN2190
Synonym:
Target: Apoptosis, Beta-Secretase, BACE, Parasite
Vincristine
T3S0209
Synonym:
Target: ERK, p38 MAPK, NF-κB, Akt, JNK, mTOR
Podofilox
T1121
Synonym: Podophyllotoxin,(+)-Shikonin
Target: Microtubule Associated, Topoisomerase
Taccalonolide B
TN2256
Synonym:
Target: Microtubule Associated
Deoxypodophyllotoxin
TN1087
Synonym:
Target: Apoptosis, Microtubule Associated, Autophagy
Taccalonolide A
TN2254
Synonym:
Target: Apoptosis, Microtubule Associated
Epothilone A
T6490
Synonym: epothile,Epo A
Target: Apoptosis, Microtubule Associated
Maytansine
T21351
Synonym: NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine
Target: Microtubule Associated, Antibiotic
Cephalomannine
T2217
Synonym: Baccatin III
Target: Microtubule Associated
Colchicine
T0320
Synonym: Colcin,Colchineos,Colchisol
Target: Apoptosis, Microtubule Associated, Autophagy
Paclitaxel
T0968
Synonym: Taxol,NSC 125973
Target: Apoptosis, Microtubule Associated, Autophagy
Maytansinol
T16016
Synonym: Ansamitocin P-0
Target: Apoptosis, Microtubule Associated
7-epi-Taxol
T3S2372
Synonym: 7-Epitaxol,7-epi-Paclitaxel
Target: Others, Microtubule Associated
Vinblastine sulfate
T1668
Synonym: NSC49842,Vincaleukoblastine sulfate salt
Target: Microtubule Associated, AChR, Autophagy
Docetaxel
T1034
Synonym: NSC 628503,RP-56976
Target: Apoptosis, Microtubule Associated, Endogenous Metabolite
Vincristine sulfate
T1270
Synonym: Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate
Target: Apoptosis, Microtubule Associated
Colcemid
T19720
Synonym: C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine
Target: Microtubule Associated
Fosbretabulin Disodium
T6272
Synonym: Combretastatin A4 Phosphate,CA 4DP,CA 4P,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium
Target: Apoptosis, Microtubule Associated
Dolastatin 10
TP1180
Synonym: NSC 376128,DLS 10
Target: Microtubule Associated
Combretastatin A4
T6212
Synonym: CA4,CRC 87-09
Target: Microtubule Associated
Vindesine sulfate
T22455
Synonym: DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS
Target: Others
2-Methoxyestradiol
T2220
Synonym: NSC-659853,2-MeOE2,2-ME2
Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated, Endogenous Metabolite, HIF, Autophagy
Docetaxel trihydrate
T0186
Synonym: RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate
Target: Apoptosis, BCL, Microtubule Associated
Albendazole
T1152
Synonym: SKF-62979
Target: HIF/HIF Prolyl-Hydroxylase, Microtubule Associated, Antibiotic, Parasite
4'-Demethylepipodophyllotoxin
T2937
Synonym: 4'-DMEP,4-Demethylepipodophyllotoxin,DMEP,4'-O-demethylepipodophyllotoxin
Target: Microtubule Associated
Cabazitaxel
T2543
Synonym: XRP6258,RPR-116258A,TXD 258,taxoid XRP6258
Target: Microtubule Associated, Autophagy
10-Deacetyltaxol
T5165
Synonym: 10-DAT,10-Desacetyl Paclitaxel,Deacetyltaxol,10-deacetyl-paclitaxel,Deacetyl Paclitaxel
Target: Others, Microtubule Associated
Vinorelbine ditartrate
T6213
Synonym: Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate
Target: Microtubule Associated, Autophagy
10-Deacetyl-7-xylosyl paclitaxel
T5749
Synonym: 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,10-Deacetylpaclitaxel 7-Xyloside
Target: Others, Microtubule Associated
Ansamitocin p-3
T22262
Synonym: Maytansinol isobutyrate,Antibiotic C 15003P3,NSC292222
Target: Microtubule Associated
PM050489
T75521
Synonym:
Target:

Recombinant Proteins

Species：
Human (7)
Expression System：
E. coli (7)
Tag：
His (2)
N-terminal 6xHis-SUMO-tagged (2)
C-6His (1)
N-terminal 6xHis-tagged (1)
N-terminal GST-tagged (1)
Cat No. Product Name Species Expression System
TMPH-02304 Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO) Human E. coli
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mito...
TMPJ-00827 Tau-D Protein, Human, Recombinant (His) Human E. coli
Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. ...
TMPY-03047 Stathmin 1 Protein, Human, Recombinant (His) Human E. coli
Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and ...
TMPH-01252 DCTN1 Protein, Human, Recombinant (His & SUMO) Human E. coli
Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between sp...
TMPH-02263 VASH1 Protein, Human, Recombinant (His) Human E. coli
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mito...
TMPH-02262 TUBB3 Protein, Human, Recombinant (GST) Human E. coli
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon...
TMPY-03509 TCTP/TPT1 Protein, Human, Recombinant (His) Human E. coli
Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activi...
Cat No. Product Name
L1110 Microtubule-Targeted Compound Library

155 compounds
A unique collection of 155 microtubule-targeted compounds can be used in HTS and HCS;
L1310 Cytoskeletal Signaling Pathway Compound Library

773 compounds
A unique collection of 773 cytoskeleton-related compounds, can be used for HTS and HCS；

Libraries

Microtubule-Targeted Compound Library
L1110
Compounds: 155
Cytoskeletal Signaling Pathway Compound Library
L1310
Compounds: 773
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