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MMAD

Catalog No. T4677 CAS 203849-91-6

Synonyms: Monomethylauristatin D, Demethyldolastatin 10, Monomethyl Dolastatin 10

MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MMAD, CAS 203849-91-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 66.00
10 mg	In stock	$ 116.00
50 mg	In stock	$ 374.00

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Purity: 99.91%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).
In vitro	MMAD (Monomethyl Dolastatin 10) undergoes a stable oxime-ligation to produce several nearly homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of approximately 2.0. These conjugates exhibit favorable pharmacokinetic properties and potent in vitro cytotoxicity against HER2+ cancer cells. Furthermore, ADCs synthesized using site-specific unnatural amino acids display enhanced in vitro cytotoxicity compared to those prepared through cysteine alkylation after native interchain disulfide reduction.
In vivo	The resulting antibody-drug conjugates (ADCs) exhibited complete tumor regression in rodents. They also have an improved toxicology profile in rats.

Synonyms	Monomethylauristatin D, Demethyldolastatin 10, Monomethyl Dolastatin 10
Molecular Weight	771.06
Formula	C41H66N6O6S
CAS No.	203849-91-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 24.5 mg/mL (31.77 mM), Sonification and heating are recommended.

References and Literature

1. Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9.

Related compound libraries

This product is contained In the following compound libraries：

Microtubule-Targeted Compound Library Bioactive Compounds Library Max Drug-induced Liver Injury (DILI) Compound Library Target-Focused Phenotypic Screening Library Cytoskeletal Signaling Pathway Compound Library NO PAINS Compound Library Anti-Aging Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MMAD 203849-91-6 Cytoskeletal Signaling Microtubule Associated inhibit Monomethylauristatin D Demethyldolastatin-10 Demethyldolastatin10 Demethyldolastatin 10 Monomethyl Dolastatin-10 Inhibitor Microtubule/Tubulin ADC Payload Monomethyl Dolastatin10 ADC Cytotoxin Monomethyl Dolastatin 10 inhibitor

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