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Flubendazole

Catalog No. T0009 CAS 31430-15-6

Synonyms: Flumoxanal, Flumoxane, NSC 313680, Fluvermal

Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Flubendazole, CAS 31430-15-6

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.66%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
In vitro	Flubendazole results in morphological changes included contraction of the soma region, the formation of blebs on the tegument, rostellar disorganization, loss of hooks and destruction of microtriches in Echinococcus granulosus. Flubendazole has a bicyclic ring system in which a benzene has been fused to the -4 and -5 positions of the heterocycle (imidazole). Flubendazole and Albendazole show similar potency in affecting rat embryonic development in vitro, inducing retardation of growth and dysmorphogenic effects at concentrations ≥0.5 μg/mL.
In vivo	Flubendazole (6.32 mg/kg/day) initially induces an arrest of embryonic development followed by a generalized cell death that leads to 100% embryolethality by gestation day (GD) 12.5. Flubendazole (3.46 mg/kg/day) markedly reduces embryonic development by GD 12.5 without causing cell death. Flubendazole in olive oil causes a statistically significant increase in embryolethality at doses of 7.83 mg/kg per day and higher, with complete resorption in all dams at 31.33 mg/kg per day in rats. Flubendazole treatment causes a slight increase of metyrapone and daunorubicin activities in hepatic as well as intestinal cytosol in birds. Flubendazole treatment leads to statistically significant inhibition of intestinal GST activity. Flubendazole treatment leads to slight but significant inhibition (decrease to 69%) of 7-ethoxyresorufin activity in hepatic microsomes.

Synonyms	Flumoxanal, Flumoxane, NSC 313680, Fluvermal
Molecular Weight	313.28
Formula	C16H12FN3O3
CAS No.	31430-15-6

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (28.73 mM)

References and Literature

1. Hou ZJ, et al. Oncotarget. 2015 Jan 21;6(8):6326-40.

Related compound libraries

This product is contained In the following compound libraries：

Microtubule-Targeted Compound Library Anti-Cancer Approved Drug Library Anti-Parasitic Compound Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Apoptosis Compound Library Target-Focused Phenotypic Screening Library Bioactive Compounds Library Max Anti-Infection Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Flubendazole 31430-15-6 Apoptosis Cytoskeletal Signaling Microbiology/Virology Parasite Microtubule Associated Microtubule/Tubulin Inhibitor Flumoxanal Flumoxane NSC313680 NSC-313680 NSC 313680 Fluvermal inhibit inhibitor

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