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Epothilone A

Catalog No. T6490   CAS 152044-53-6
Synonyms: epothile, Epo A

Epothilone A (Epo A) is a microtubule-stabilizing agent with EC0.01 of 2 μM.

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Epothilone A Chemical Structure
Epothilone A, CAS 152044-53-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 31.00
2 mg In stock $ 44.00
5 mg In stock $ 72.00
10 mg In stock $ 118.00
25 mg In stock $ 239.00
50 mg In stock $ 363.00
100 mg In stock $ 547.00
200 mg In stock $ 779.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 99.48%
Purity: 98.27%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Epothilone A (Epo A) is a microtubule-stabilizing agent with EC0.01 of 2 μM.
Targets&IC50 Tubulin:2 μM(EC0.01)
Kinase Assay Tubulin polymerization assay: Samples for electron microscopy are placed on carbon-over-Parlodion-coated grids (300 mesh) and negatively stained with 2% uranyl acetate. Microtubule assembly in the presence or absence of Epothilone A is monitored spectrophotometrically by using a spectrophotometer equipped with a thermostatically regulated liquid circulator. The temperature is held at 35 °C and changes in turbidity (representative of polymer mass) are monitored at 350 nm. Effective concentration (EC0.01), defined as the interpolated concentration capable of inducing an initial slope of 0.01 OD/min rate, is calculated using the formula EC0.01 = concentration/slope.
Cell Research Cell lines: KB3-1,KBV-1,Hela,and Hs578T cells. Concentrations: 0–2 μM. Method: cells are plated either in 48-well plates (for trypan blue and cell counting) or onto coverslips.After 24 hours,cells are treated with Epothilone A and are scored at regular intervals.For the cytotoxicity analysis,cells are counted and scored as trypan blue positive or negative.
Synonyms epothile, Epo A
Molecular Weight 493.66
Formula C26H39NO6S
CAS No. 152044-53-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 92 mg/mL (186.4 mM)

DMSO: 92 mg/mL (186.4 mM)

TargetMolReferences and Literature

1. Regueiro-Ren A , et al. Org Lett, 2001, 3(17), 2693-2696. 2. Bollag DM, et al. Cancer Res, 1995, 55(11), 2325-2333. 3. Nettles JH, et al. Science, 2004, 305(5685), 866-869. 4. Wang YL, et al. J Asian Nat Prod Res, 2009, 11(4), 357-364. 5. Swindell CS, et al. J Med Chem, 1991, 34(3), 1176-1184.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Microbial Natural Product Library Microtubule-Targeted Compound Library Bioactive Compound Library Human Metabolite Library Target-Focused Phenotypic Screening Library Anti-Aging Compound Library RO5 Drug-like Natural Product Library Cytoskeletal Signaling Pathway Compound Library Natural Product Library

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Keywords

Epothilone A 152044-53-6 Apoptosis Cytoskeletal Signaling Microtubule Associated Inhibitor inhibit Microtubule/Tubulin epothile Epo A inhibitor

 

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