Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Epothilone A (Epo A) is a microtubule-stabilizing agent with EC0.01 of 2 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 118.00 | |
25 mg | In stock | $ 239.00 | |
50 mg | In stock | $ 363.00 | |
100 mg | In stock | $ 547.00 | |
200 mg | In stock | $ 779.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | Epothilone A (Epo A) is a microtubule-stabilizing agent with EC0.01 of 2 μM. |
Targets&IC50 | Tubulin:2 μM(EC0.01) |
Kinase Assay | Tubulin polymerization assay: Samples for electron microscopy are placed on carbon-over-Parlodion-coated grids (300 mesh) and negatively stained with 2% uranyl acetate. Microtubule assembly in the presence or absence of Epothilone A is monitored spectrophotometrically by using a spectrophotometer equipped with a thermostatically regulated liquid circulator. The temperature is held at 35 °C and changes in turbidity (representative of polymer mass) are monitored at 350 nm. Effective concentration (EC0.01), defined as the interpolated concentration capable of inducing an initial slope of 0.01 OD/min rate, is calculated using the formula EC0.01 = concentration/slope. |
Cell Research | Cell lines: KB3-1,KBV-1,Hela,and Hs578T cells. Concentrations: 0–2 μM. Method: cells are plated either in 48-well plates (for trypan blue and cell counting) or onto coverslips.After 24 hours,cells are treated with Epothilone A and are scored at regular intervals.For the cytotoxicity analysis,cells are counted and scored as trypan blue positive or negative. |
Synonyms | epothile, Epo A |
Molecular Weight | 493.66 |
Formula | C26H39NO6S |
CAS No. | 152044-53-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 92 mg/mL (186.4 mM)
DMSO: 92 mg/mL (186.4 mM)
You can also refer to dose conversion for different animals. More
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Epothilone A 152044-53-6 Apoptosis Cytoskeletal Signaling Microtubule Associated Inhibitor inhibit Microtubule/Tubulin epothile Epo A inhibitor