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SSE15206

Catalog No. T5699 CAS 1370046-40-4

SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.

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SSE15206, CAS 1370046-40-4

Pack Size	Availability	Price/USD
2 mg	In stock	$ 41.00
5 mg	In stock	$ 60.00
10 mg	In stock	$ 78.00
25 mg	In stock	$ 157.00
50 mg	In stock	$ 241.00
100 mg	In stock	$ 377.00
1 mL * 10 mM (in DMSO)	In stock	$ 67.00

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Purity: 98%

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Description	SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
Targets&IC50	Microtubule:197 nM (GI50)
In vitro	Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation, a phenotype often associated with drugs that interfere with microtubule dynamics. SSE15206 is able to overcome resistance to chemotherapeutic drugs in different cancer cell lines including multidrug-resistant KB-V1 and A2780-Pac-Res cell lines overexpressing MDR-1, making it a promising hit for the lead optimization studies to target multidrug resistance.
Cell Research	Fluorescence intensity of tubulin (4?μM) in the presence of colchicine (20?μM) and SSE15206 at indicated concentrations was measured. DMSO was used as a solvent control while 50?μM nocodazole was used as a positive control for colchicine displacement. Samples were incubated for 60?min at 37℃before measurement of fluorescence (excitation at 355?nm and emission at 460?nm). KB-V1 and A2780-Pac-Res cells were incubated with 5?μM rhodamine, for 1?hour at 37℃in the presence or absence of inhibitors. Cells were then washed twice with PBS and incubated in the efflux medium (their respective growth media) in the presence of DMSO, 20?μM verapamil, and 10?μM SSE15206 for 3?hours. The percentage of rhodamine 123 positive cells was determined . Experiments were done in duplicates with 4–5 readings for each sample in each experiment.

Molecular Weight	371.45
Formula	C19H21N3O3S
CAS No.	1370046-40-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (403.82 mM)

References and Literature

1. Manzoor S , Bilal A , Khan S , et al. Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance[J]. Scientific Reports, 2018, 8(1).

Related compound libraries

This product is contained In the following compound libraries：

Microtubule-Targeted Compound Library Anti-Cancer Active Compound Library Inhibitor Library Bioactive Compounds Library Max NO PAINS Compound Library Anti-Aging Compound Library Anti-Cancer Compound Library Cytoskeletal Signaling Pathway Compound Library Apoptosis Compound Library Bioactive Compound Library

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Keywords

SSE15206 1370046-40-4 Apoptosis Cytoskeletal Signaling Microtubule Associated Inhibitor SSE 15206 Microtubule/Tubulin inhibit SSE-15206 inhibitor

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