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Cytoskeletal Signaling Microtubule Associated SSE15206

SSE15206

Catalog No. T5699   CAS 1370046-40-4

SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.

SSE15206, CAS 1370046-40-4
Pack Size Availability Price/USD Quantity
2 mg In Stock 50.00
5 mg In Stock 67.00
10 mg In Stock 87.00
25 mg In Stock 182.00
50 mg In Stock 285.00
100 mg In Stock 419.00
1 mL * 10 mM (in DMSO) In Stock 75.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
Targets&IC50 microtubule
In vitro Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation, a phenotype often associated with drugs that interfere with microtubule dynamics. SSE15206 is able to overcome resistance to chemotherapeutic drugs in different cancer cell lines including multidrug-resistant KB-V1 and A2780-Pac-Res cell lines overexpressing MDR-1, making it a promising hit for the lead optimization studies to target multidrug resistance.
Cell Research
Fluorescence intensity of tubulin (4 μM) in the presence of colchicine (20 μM) and SSE15206 at indicated concentrations was measured. DMSO was used as a solvent control while 50 μM nocodazole was used as a positive control for colchicine displacement. Samples were incubated for 60 min at 37℃before measurement of fluorescence (excitation at 355 nm and emission at 460 nm). KB-V1 and A2780-Pac-Res cells were incubated with 5 μM rhodamine, for 1 hour at 37℃in the presence or absence of inhibitors. Cells were then washed twice with PBS and incubated in the efflux medium (their respective growth media) in the presence of DMSO, 20 μM verapamil, and 10 μM SSE15206 for 3 hours. The percentage of rhodamine 123 positive cells was determined . Experiments were done in duplicates with 4–5 readings for each sample in each experiment.
Molecular Weight 371.45
Formula C19H21N3O3S
CAS No. 1370046-40-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 150 mg/mL (403.82 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Manzoor S , Bilal A , Khan S , et al. Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance[J]. Scientific Reports, 2018, 8(1).

Related Products

Related compounds with same targets
Tubulin inhibitor 6 Deoxypodophyllotoxin Verubulin hydrochloride BO-264 Vinflunine Tartrate SSE15206 VERU-111 Verubulin

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