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10-Deacetyl-7-xylosyl paclitaxel

Catalog No. T5749 CAS 90332-63-1

Synonyms: 10-Deacetyl-7-xylosyltaxol, 10-Deacetyltaxol 7-Xyloside, 7-Xylosyl-10-deacetyltaxol, 10-Deacetylpaclitaxel 7-Xyloside

10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer.

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10-Deacetyl-7-xylosyl paclitaxel Chemical Structure

10-Deacetyl-7-xylosyl paclitaxel, CAS 90332-63-1

Pack Size	Availability	Price/USD	Quantity
5 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 95.00

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Purity: 99.76%

Purity: 98%

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Description	10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer.
In vitro	7-Xylosyl-10-deacetyltaxol induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9[1].
In vivo	7-Xylosyl-10-deacetyltaxol is an active compound used in traditional Chinese medicine to treat cancer.7-Xylosyl-10-deacetyltaxol through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 7-Xylosyl-10-deacetyltaxol transport (16.3?±?6.3?×?10 (-6)?cm/s; n?=?3) suggests that the drug may still be effectively absorbed in the intestinal tract[2].
Source	Natural Products > Taxaceae > Taxus

Synonyms	10-Deacetyl-7-xylosyltaxol, 10-Deacetyltaxol 7-Xyloside, 7-Xylosyl-10-deacetyltaxol, 10-Deacetylpaclitaxel 7-Xyloside
Molecular Weight	943.98
Formula	C50H57NO17
CAS No.	90332-63-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (26.48 mM)

References and Literature

1. Jiang S , Zu Y , Fu Y , et al. Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a novel hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel[J]. International Journal of Oncology, 2008, 33(1):103---111. 2. Jiang S , Zu Y , Zhang Y , et al. Transport of a Hydrophilic Paclitaxel Derivative, 7-Xylosyl-10-Deacetylpaclitaxel, by Human Intestinal Epithelial Caco-2 Cells[J]. Planta medica, 2010, 76(14).

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Microtubule-Targeted Compound Library Anti-Tumor Natural Product Library Anti-Cancer Compound Library Selected Plant-Sourced Compound Library Terpene Natural Product Library Bioactive Compound Library Traditional Chinese Medicine Monomer Library NO PAINS Compound Library Bioactive Compounds Library Max

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Keywords

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