Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induce apoptotic cell death.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 43.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 178.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 463.00 | |
100 mg | In stock | $ 668.00 | |
500 mg | In stock | $ 1,380.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induce apoptotic cell death. |
In vitro | In MCF7 cells, the treatment of Batabulin (T138067; 30-300 nM; 24 hours) shows approximately 25-30% tetraploid (4n) DNA content in cells and 25-30% apoptosis. After a 48-hr exposure to 100 nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis. Batabulin binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1, β2, and β4 tubulin isotypes. Cells exposed to Batabulin become altered in shape. |
In vivo | Batabulin (40 mg/kg; i.p.; once per week; on days 5, 12, and 19; male athymic nude mice) treatment impairs the growth of the drug-sensitive CCRF-CEM tumors. |
Synonyms | T138067 |
Molecular Weight | 371.26 |
Formula | C13H7F6NO3S |
CAS No. | 195533-53-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (269.35 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Batabulin 195533-53-0 Apoptosis Cytoskeletal Signaling Microtubule Associated multidrug-resistant polymerization cytoskeleton covalent Cys-239 β-tubulin arrest Inhibitor Microtubule/Tubulin Antimitotic inhibit T 138067 T-138067 cell-cycle antitumor T138067 inhibitor