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Cabazitaxel

Catalog No. T2543 CAS 183133-96-2

Synonyms: TXD 258, taxoid XRP6258, RPR-116258A, XRP6258

Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Cabazitaxel, CAS 183133-96-2

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 51.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.88%

Purity: 98.14%

Purity: 98%

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Description	Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.
Cell Research	The cytotoxicity of CBX-loaded ANs and free Cabazitaxel (CBX) is evaluated with MTT assay. Cells are seeded onto a 96-well plate at a density of 3000 cells per well and cultured for 24 h. CBX-loaded ANs and free CBX are diluted to predetermined concentrations with PBS and added into each well. Blank AN, AN-ICG and free CBX solvent (a mixture of Tween-80 and anhydrous alcohol) are added as well to different final concentrations. The incubation continued for another 48 hours. 20 μL MTT solutions (5 mg/mL in PBS) are added into each well and cells are incubated for another 4 hours under 37°C. Subsequently the medium is removed and 150 μL dimethyl sulphoxide (DMSO) is added to dissolve the purple formazan salt crystals. Then the absorbance is measured by a microplate reader at 490 nm. The cells treated with medium are evaluated as controls.
Source	Natural Products > Taxaceae > Taxus

Synonyms	TXD 258, taxoid XRP6258, RPR-116258A, XRP6258
Molecular Weight	835.93
Formula	C45H57NO14
CAS No.	183133-96-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: <1 mg/mL

DMSO: 93 mg/mL (111.3 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. EMEA/H/C/002018, 2011. 2. Pal SK, et al. Clin Interv Aging, 2010, 5, 395-402.

Citations

1. Zhang W, Sun R, Zhang Y, et al. Cabazitaxel suppresses colorectal cancer cell growth via enhancing the p53 anti‐tumor pathway FEBS Open Bio, 2021.. FEBS Open Bio. 2021

Related compound libraries

This product is contained In the following compound libraries：

Clinical Compound Library Anti-Cancer Clinical Compound Library Anti-Aging Compound Library Bioactive Compounds Library Max Natural Product Library Anti-Pancreatic Cancer Compound Library Drug-induced Liver Injury (DILI) Compound Library NO PAINS Compound Library Selected Plant-Sourced Compound Library Tibetan medicine Compound Library

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Keywords

Cabazitaxel 183133-96-2 Autophagy Cytoskeletal Signaling Microtubule Associated Microtubule/Tubulin taxoid XRP 6258 TXD 258 taxoid XRP6258 RPR-116258A taxoid XRP-6258 XRP 6258 inhibit XRP-6258 XRP6258 Inhibitor inhibitor

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