Home Tools
Log in
Cart

Cabazitaxel

Catalog No. T2543   CAS 183133-96-2
Synonyms: TXD 258, taxoid XRP6258, RPR-116258A, XRP6258

Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Cabazitaxel, CAS 183133-96-2
Pack Size Availability Price/USD Quantity
20 mg In stock $ 51.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.88%
Purity: 98.14%
Purity: 98%
Purity: 98%
Purity: 98%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.
Cell Research The cytotoxicity of CBX-loaded ANs and free Cabazitaxel (CBX) is evaluated with MTT assay. Cells are seeded onto a 96-well plate at a density of 3000 cells per well and cultured for 24 h. CBX-loaded ANs and free CBX are diluted to predetermined concentrations with PBS and added into each well. Blank AN, AN-ICG and free CBX solvent (a mixture of Tween-80 and anhydrous alcohol) are added as well to different final concentrations. The incubation continued for another 48 hours. 20 μL MTT solutions (5 mg/mL in PBS) are added into each well and cells are incubated for another 4 hours under 37°C. Subsequently the medium is removed and 150 μL dimethyl sulphoxide (DMSO) is added to dissolve the purple formazan salt crystals. Then the absorbance is measured by a microplate reader at 490 nm. The cells treated with medium are evaluated as controls.
Source
Synonyms TXD 258, taxoid XRP6258, RPR-116258A, XRP6258
Molecular Weight 835.93
Formula C45H57NO14
CAS No. 183133-96-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: <1 mg/mL

DMSO: 93 mg/mL (111.3 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. EMEA/H/C/002018, 2011. 2. Pal SK, et al. Clin Interv Aging, 2010, 5, 395-402.

Citations

1. Zhang W, Sun R, Zhang Y, et al. Cabazitaxel suppresses colorectal cancer cell growth via enhancing the p53 anti‐tumor pathway FEBS Open Bio, 2021.. FEBS Open Bio. 2021

Related compound libraries

This product is contained In the following compound libraries:
Clinical Compound Library Anti-Cancer Clinical Compound Library Anti-Aging Compound Library Bioactive Compounds Library Max Natural Product Library Anti-Pancreatic Cancer Compound Library Drug-induced Liver Injury (DILI) Compound Library NO PAINS Compound Library Selected Plant-Sourced Compound Library Tibetan medicine Compound Library

Related Products

Related compounds with same targets
Tasidotin hydrochloride Verubulin Vinblastine Tubulysin A OSIP-486823 Tubulin inhibitor 1 AZ82 CCB02

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cabazitaxel 183133-96-2 Autophagy Cytoskeletal Signaling Microtubule Associated Microtubule/Tubulin taxoid XRP 6258 TXD 258 taxoid XRP6258 RPR-116258A taxoid XRP-6258 XRP 6258 inhibit XRP-6258 XRP6258 Inhibitor inhibitor