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4'-Demethylepipodophyllotoxin

Name: 4'-Demethylepipodophyllotoxin
Brand: TargetMol
SKU: T2937
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2937Cas No. 6559-91-7

Alias DMEP, 4'-O-demethylepipodophyllotoxin, 4'-DMEP, 4-Demethylepipodophyllotoxin

4'-Demethylepipodophyllotoxin (DMEP) is a potent inhibitor of microtubule assembly.

4'-Demethylepipodophyllotoxin

🥰Excellent

Purity: 99.72%

Catalog No. T2937Alias DMEP, 4'-O-demethylepipodophyllotoxin, 4'-DMEP, 4-DemethylepipodophyllotoxinCas No. 6559-91-7

4'-Demethylepipodophyllotoxin (DMEP) is a potent inhibitor of microtubule assembly.

Pack Size	Price	Availability	Quantity
1 g	$35	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.72%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	4'-Demethylepipodophyllotoxin (DMEP) is a potent inhibitor of microtubule assembly.
Targets&IC50	Microtubule:0.31μM(EC50)
Synonyms	DMEP, 4'-O-demethylepipodophyllotoxin, 4'-DMEP, 4-Demethylepipodophyllotoxin

Chemical Properties

Molecular Weight	400.38
Formula	C₂₁H₂₀O₈
Cas No.	6559-91-7
Smiles	O=C1[C@@]2([C@@H](C=3C([C@@H](O)[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(O)C(OC)=C5)[H]
Relative Density.	1.446 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (124.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4976 mL	12.4881 mL	24.9763 mL	124.8814 mL
5 mM	0.4995 mL	2.4976 mL	4.9953 mL	24.9763 mL
10 mM	0.2498 mL	1.2488 mL	2.4976 mL	12.4881 mL
20 mM	0.1249 mL	0.6244 mL	1.2488 mL	6.2441 mL
50 mM	0.0500 mL	0.2498 mL	0.4995 mL	2.4976 mL
100 mM	0.0250 mL	0.1249 mL	0.2498 mL	1.2488 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc