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Maytansine

Catalog No. T21351 CAS 35846-53-8

Synonyms: NSC-153858, NSC153858, Maitansina, NSC 153858, Maitansine

Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.

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Maytansine, CAS 35846-53-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 59.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 238.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 92.00

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Purity: 99.62%

Purity: 98.43%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	NSC-153858, NSC153858, Maitansina, NSC 153858, Maitansine
Molecular Weight	692.2
Formula	C34H46ClN3O10
CAS No.	35846-53-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 60 mg/ml (86.68 mM)

References and Literature

1. Kusari S, Lamshöft M, Kusari P, Gottfried S, Zühlke S, Louven K, Hentschel U, Kayser O, Spiteller M. Endophytes are hidden producers of maytansine in Putterlickia roots. J Nat Prod. 2014 Dec 26;77(12):2577-84. 2. Tang X, Dai H, Zhu Y, Tian Y, Zhang R, Mei R, Li D. Maytansine-loaded star-shaped folate-core PLA-TPGS nanoparticles enhancing anticancer activity. Am J Transl Res. 2014 Oct 11;6(5):528-37. eCollection 2014. 3. Wings S, Müller H, Berg G, Lamshöft M, Leistner E. A study of the bacterial community in the root system of the maytansine containing plant Putterlickia verrucosa. Phytochemistry. 2013 Jul;91:158-64. 4. Lopus M, Oroudjev E, Wilson L, Wilhelm S, Widdison W, Chari R, Jordan MA. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010 Oct;9(10):2689-99.

Related compound libraries

This product is contained In the following compound libraries：

Microtubule-Targeted Compound Library Anti-Cancer Active Compound Library Anti-Cancer Compound Library Antibiotics Library Covalent Inhibitor Library Anti-infective Natural Product Library Natural Product Library for HTS NO PAINS Compound Library Bioactive Compound Library Macrocyclic Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Maytansine 35846-53-8 Cytoskeletal Signaling Microbiology/Virology Microtubule Associated Antibiotic NSC-153858 Microtubule/Tubulin tumor mitotic microtubule-targeted arrest NSC153858 Maitansina Inhibitor NSC 153858 potent subnanomolar Maitansine inhibit inhibitor

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