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Auristatin E

Catalog No. T14348 CAS 160800-57-7

Auristatin E inhibits cell division by blocking the polymerisation of tubulin. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. Auristatin E, an MMAE analog, is cytotoxin in Antibody-drug conjugates.

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Auristatin E, CAS 160800-57-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 48.00
10 mg	In stock	$ 74.00
25 mg	In stock	$ 134.00
50 mg	In stock	$ 224.00
1 mL * 10 mM (in DMSO)	In stock	$ 93.00

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Purity: 98.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	732.01
Formula	C40H69N5O7
CAS No.	160800-57-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 60 mg/ml (81.97 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65. 2. Li D, et al. DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-Hodgkin lymphoma. Mol Cancer Ther. 2013 Jul;12(7):1255-65.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Microtubule-Targeted Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compounds Library Max Human Metabolite Library Anti-Cancer Compound Library Inhibitor Library Bioactive Compound Library Cell Cycle Compound Library

Related Products

Related compounds with same targets

Tasidotin hydrochloride Verubulin Vinblastine Tubulysin A OSIP-486823 Tubulin inhibitor 1 AZ82 CCB02

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Auristatin E 160800-57-7 Cytoskeletal Signaling Microtubule Associated inhibit ADC Payload ADC Cytotoxin Inhibitor Microtubule/Tubulin inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.