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ABT-751

Catalog No. T1758   CAS 141430-65-1
Synonyms: E7010

ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
ABT-751 Chemical Structure
ABT-751, CAS 141430-65-1
Pack Size Availability Price/USD Quantity
5 mg In stock $ 41.00
10 mg In stock $ 61.00
25 mg In stock $ 124.00
50 mg In stock $ 182.00
100 mg In stock $ 291.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Purity: 99.48%
Purity: 99.42%
Purity: 98.84%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
Targets&IC50 neuroblastoma:1.5 μM
Kinase Assay High-throughput screening: For HTS, USP1-UAF1 activity is monitored using ubiquitin-rhodamine 110 as a substrate, where hydrolysis of the amide bond between the C-terminal glycine of ubiquitin and rhodamine results in an increase in fluorescence. The assay is miniaturized to a 4 μL volume in a 1,536-well format and is used to screen approximately 402,701 compounds in quantitative HTS mode, with each compound tested over a range of four to five concentrations. The assay shows robust performance with an average Z'factor of 0.8 throughout the screen.
Cell Research Cells, in 1640 RPMI media with FBS, are plated in triplicate onto 96 well tissue culture plates in numbers determined optimal for confluent monolayer growth (5,000 cells/well for HOS, HTB-186 Daoy; 10,000 cells/well for TC-71, RD, SK-N-AS, SK-N-DZ, LD; 30,000 cells/well for KCNR), with an automated, multichannel pipette system. Cells are incubated for 24 hours at 37 °C/5% CO2 then exposed to vehicle control (1.25% DMSO/Water), VCR (0.1–1000 nM), ABT-751 (0.1 nM–100 μM), and in 4 cell lines (SK-N-AS, KCNR, RD, TC-71) combretastatin (0.1–1000 nM) for 72 hours. Cells are fixed with trichloroacetic acid (final concentration 10%) at 4 °C, washed, then dried at room temperature, stained with SRB in 1% acetic acid and dye is then solubilized with Tris base. Optical density measurements are performed at 540 and 405 nm dual wavelengths in a Bio-Tek EL 340 UV plate reader. (Only for Reference)
Synonyms E7010
Molecular Weight 371.41
Formula C18H17N3O4S
CAS No. 141430-65-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 37.1 mg/mL (100 mM)

Ethanol: 9.3 mg/mL (25 mM)

TargetMolReferences and Literature

1. Meany HJ, et al. Pediatr Blood Cancer. 2010, 54(1), 47-54. 2. Jorgensen TJ, et al. Cancer Chemother Pharmacol. 2007, 59(6), 725-732. 3. Silver M, et al. J Vet Intern Med. 2012, 26(2), 349-354.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Microtubule-Targeted Compound Library Anti-Aging Compound Library Pediatric Drug Library Bioactive Compound Library Bioactive Compounds Library Max Autophagy Compound Library Anti-Liver Cancer Compound Library

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Keywords

ABT-751 141430-65-1 Autophagy Cytoskeletal Signaling Microtubule Associated E7010 Microtubule/Tubulin ABT 751 Inhibitor inhibit ABT751 E-7010 E 7010 inhibitor

 

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