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Triclabendazole

Catalog No. T0838 CAS 68786-66-3

Synonyms: CGA89317

Triclabendazole has been used in trials studying Parasitic Disease.

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Triclabendazole, CAS 68786-66-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Triclabendazole has been used in trials studying Parasitic Disease.

In vitro

Triclabendazole treatment produces percentage decreases of the fluke egg output by 15.3%, 4.3% and 36.6%, respectively, in sheep, dairy cows and heifers, these results indicate the presence of TCBZ-resistant Fasciola hepatica in sheep and cattle on this farm. [1] Triclabendazole sulphoxide (50 mg/mL) results in extensive damage to the tegument of triclabendazole-susceptible F. hepatica, whereas triclabendazole-resistant flukes shows only localized and relatively minor disruption of the tegument covering the spines. [2]

Synonyms	CGA89317
Molecular Weight	359.66
Formula	C14H9Cl3N2OS
CAS No.	68786-66-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 67 mg/mL (186.3 mM)

H2O: <1 mg/mL

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Moll L, et al. Vet Parasitol, 2000, 91(1-2), 153-158. 2. Robinson MW, et al. Parasitology, 2002, 124(Pt 3), 325-338. 3. Fairweather I, et al. J Helminthol, 2005, 79(3), 227-234. 4. Hennessy DR, et al. J Vet Pharmacol Ther, 1987, 10(1), 64-72. 5. Coles GC, et al. J Helminthol, 1986, 60(3), 210-212.

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You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Triclabendazole 68786-66-3 Cytoskeletal Signaling Microbiology/Virology Parasite Microtubule Associated CGA 89317 CGA89317 Inhibitor Microtubule/Tubulin inhibit CGA-89317 inhibitor

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