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Estramustine

Catalog No. T20681 CAS 2998-57-4

Synonyms: NSC-89201, NSC 89201, LEO 275, LEO275, NSC89201, LEO-275

Estramustine (LEO-275) is a nitrogen mustard linked to estradiol, usually as phosphate. Estramustine has been used to treat prostatic neoplasms; also has radiation protective properties. Estramustine is selectively taken up by prostate cells and exerts antineoplastic effects by interfering with microtubule of dynamics and by reducing plasma levels of testosterone.

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Estramustine, CAS 2998-57-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 128.00
50 mg	In stock	$ 213.00
100 mg	In stock	$ 347.00
500 mg	In stock	$ 825.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 99.25%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	NSC-89201, NSC 89201, LEO 275, LEO275, NSC89201, LEO-275
Molecular Weight	440.4
Formula	C23H31Cl2NO3
CAS No.	2998-57-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (124.89 mM)

References and Literature

1. Perry CM, McTavish D. Estramustine phosphate sodium. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer. Drugs Aging. 1995 Jul;7(1):49-74. 2. Zhang C, Jing T, Wang F, Gao X, Xu C, Sun Y. Chemotherapy plus estramustine for management of castration-resistant prostate cancer: meta-analysis of randomized controlled trials. Actas Urol Esp. 2014 Apr;38(3):184-91. doi: 10.1016/j.acuro.2013.07.010. Epub 2014 Feb 5. English, Spanish. PubMed PMID: 24507454. 3. Nakai Y, Nishimura K, Nakayama M, Uemura M, Takayama H, Nonomura N, Tsujimura A; Osaka CRPC Clinical Study Collaboration. Weekly, low-dose docetaxel combined with estramustine for Japanese castration-resistant prostate cancer: its efficacy and safety profile compared with tri-weekly standard-dose treatment. Int J Clin Oncol. 2014 Feb;19(1):165-72. doi: 10.1007/s10147-013-0536-7. Epub 2013 Mar 1. PubMed PMID: 23456140. 4. Qin Z, Li X, Zhang J, Tang J, Han P, Xu Z, Yu Y, Yang C, Wang C, Xu T, Xu Z, Zou Q. Chemotherapy with or without estramustine for treatment of castration-resistant prostate cancer: A systematic review and meta-analysis. Medicine (Baltimore). 2016 Sep;95(39):e4801. doi: 10.1097/MD.0000000000004801. Review. PubMed PMID: 27684806; PubMed Central PMCID: PMC5265899.

Related compound libraries

This product is contained In the following compound libraries：

Microtubule-Targeted Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library ReFRAME Related Library Anti-Prostate Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Estramustine 2998-57-4 Cytoskeletal Signaling Microtubule Associated Microtubule/Tubulin NSC-89201 NSC 89201 inhibit prostate tumor LEO 275 Inhibitor LEO275 NSC89201 antineoplastic LEO-275 depolymerization antimitotic inhibitor

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