Search Result

Search Results for " aβ "

164

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T63208L	Aβ-IN-1 TFA	Aβ-IN-1 TFA（2766509-32-2 Free base）
	Aβ-IN-1 TFA inhibits and reverses different types of protein aggregation.
T63208	Aβ-IN-1		Gamma-secretase
	Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ-IN-1 shows a sustained pharma...		Gamma-secretase
T39781	Aβ/tau aggregation-IN-1
	Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ 1-42 β-sheet formation and tau aggregation. It exhibits K D values of 160 μM and 337 μM with Aβ 1-42 and tau, respectively. Additionally, Aβ/tau aggregation-IN-1 can pe...
T61178	Aβ-IN-5
	Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor that also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Furthermore, Aβ-IN-5 exhibits remarkable neuroprotective effec...
T78884	Aβ-IN-7
	Aβ-IN-7 (compound 5a) acts as a potent inhibitor of Aβ aggregation, stabilizing Aβ monomers at 50 μM concentration to prevent them from forming larger oligomers and delaying the nucleation phase. Comparative studies demo...
T78885	Aβ-IN-8
	Aβ-IN-8, also known as compound 7e, is a potent inhibitor of Aβ aggregation [1].
T63689	Aβ-IN-2
	Aβ-IN-2 is a peptide inhibitor of Aβ1-42. Aβ-IN-2 inhibits the in vitro self-aggregation of Aβ1-42 by delaying the growth phase of the Aβ1-42 index or by reducing the number of protofibrils in the steady state.
T78698	Aβ-IN-6
	Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's disease (AD) research [1]. It effectively reduces the release ...
T79571	AChE/Aβ-IN-2
	AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM. It also functions as an NMDA receptor antagonist (GluN1-1b/GluN2B subunit combination) with an IC50 of...
T74158	Aβ Fibrillization modulator 1
	Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.
T63873	Anti-Aβ agent 1A
	Anti-Aβ agent 1A is a potent anti-amyloid-β agent. Anti-Aβ agent 1A significantly inhibits LPS-induced IL-1β, IL-6 and TNF-α levels and reduces H2O2-induced apoptosis in SH-SY5Y cells using the mitochondrial pathway, exh...
T79569	AChE/Aβ-IN-1
	AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the GluN1-1b/GluN2B subunit combination with an IC50 of 3.876 μM...
T78173	Aβ/tau aggregation-IN-3
	Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functional aggregation assay. This compound demonstrates anti-amyloid activ...
T7527	Frentizole		Beta Amyloid
	Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction		Beta Amyloid
T0204	Protriptyline hydrochloride	Protriptyline HCl	5-HT Receptor , AChE
	Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochloride (Protriptyline HCl) blocks the re-uptake of norepineph...		5-HT Receptor , AChE
T16133	MRK-560		Gamma-secretase
	MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.		Gamma-secretase
T22012	7BIO		FLT , DYRK , Aurora Kinase
	7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.		FLT , DYRK , Aurora Kinase
T22678	3,5-Bis(4-nitrophenoxy)benzoic acid	Compound W	Gamma-secretase
	3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).		Gamma-secretase
TP2045	CH 275
	Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin r...
T12374	PAβN dihydrochloride	MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride	Others , Antibacterial
	PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump.		Others , Antibacterial
T9641	Aβ42-IN-2		Gamma-secretase
	Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].		Gamma-secretase
T21609L	Beta-Sheet Breaker Peptide iAβ5 Acetate	Beta-Sheet Breaker Peptide iAβ5 Acetate(182912-74-9 Free base)	Others
	Beta-Sheet Breaker Peptide iAβ5 Acetate (C33H43N5O8) inhibit amyloidogenesis in rat brain models.		Others
T60940	ChE/Aβ1-42-IN-1
	ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability. The IC50 values of ChE/Aβ1-42-IN-1 for AChE, BuChE and Aβ 1-42 aggregation are 0.062, 0.767 and 1.227 μM...
T74811	Tau/Aβ40 aggregation-IN-1
	Tau/Aβ40 aggregation-IN-1 (Compound 20) functions as an inhibitor for tau and Aβ 40 aggregation, exhibiting IC50 values of 1.8 μM and 1.3 μM, respectively [1].
T64238	Aβ1–42 aggregation inhibitor 1
	Aβ1-42 aggregation inhibitor 1 effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), demonstrating IC50 values of 2.64 μM and 1.29 μM, respectively. At a concentration of 25 μM, it also redu...
T10443	Aβ42-IN-1 free base		Others
	Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091 μM, and significantly diminishes brain Aβ42 levels in mice....		Others
T61388	HAChE/Aβ1-42-IN-1
	Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and excellent brain-blood barrier (BBB) penetration with a broad sa...
T10211	Aβ42-IN-1		Others
	Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ42-IN-1 show...		Others
T19892	BSBM7		Beta Amyloid
	BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.		Beta Amyloid
T4077	PE859		Beta Amyloid , Gamma-secretase , Microtubule Associated
	PE859 is a potent inhibitor of both tau and Aβ aggregation.		Beta Amyloid , Gamma-secretase , Microtubule Associated
T21470L	Davunetide acetate	Davunetide acetate(211439-12-2 Free base)	Beta Amyloid , Microtubule Associated
	Davunetide acetate is derived from activity-dependent neuroprotective protein existing in the mammalian CNS. Davunetide acetate is a microtubule-stabilizing peptide and inhibits Aβ aggregation and Aβ-induced neurotoxicit...		Beta Amyloid , Microtubule Associated
T14690	BMS 433796	BMS-289948,BMS-299897	Beta Amyloid
	BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.		Beta Amyloid
T7490	ARN2966		Beta Amyloid
	ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.		Beta Amyloid
TQ0026	MDR-1339	DWK-1339	Beta Amyloid , Gamma-secretase
	MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.		Beta Amyloid , Gamma-secretase
T7680	GSNKGAIIGLM(131602-53-4(free base))	Amyloid beta-peptide(25-35)	Beta Amyloid
	GSNKGAIIGLM(131602-53-4(free base)) (Amyloid beta-peptide(25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide.		Beta Amyloid
T14673	BMS 299897		Beta Amyloid , Gamma-secretase
	BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).		Beta Amyloid , Gamma-secretase
T3259	FPS-ZM1		Beta Amyloid , advanced glycation end products
	FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.		Beta Amyloid , advanced glycation end products
T14284	β-Amyloid (25-35)	β-Amyloid peptide(25-35),Aβ25-35,Amyloid beta-peptide(25-35)	Beta Amyloid
	β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.		Beta Amyloid
T22972	Methoxy-X04		Others
	Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).		Others
T63540	Astrophloxine		Beta Amyloid
	Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples from Alzheimer's disease (AD) mice.		Beta Amyloid
T4422	Edonerpic maleate	T-817MA,T-817 maleate	Beta Amyloid
	Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).		Beta Amyloid
T14338	Atabecestat	JNJ-54861911	BACE
	Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a ...		BACE
T77042	Aducanumab	BIIB037	Beta Amyloid
	Aducanumab (BIIB037), A selective human immunoglobulin gamma-1 (IgG1) monoclonal antibody, targets the clustered form of amyloid beta (Aβ). Aducanumab shows brain permeability and may be used to treat Alzheimer's disease...		Beta Amyloid
T4398	LX2343		Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
	LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.		Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
T4364	Aftin-4	Aftin 4,Aftin4	Beta Amyloid , Gamma-secretase
	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus...		Beta Amyloid , Gamma-secretase
T6202	DAPT	LY-374973,GSI-IX	Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy
	DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.		Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy
T2639	LY2811376		Beta Amyloid , Beta-Secretase , BACE
	LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition...		Beta Amyloid , Beta-Secretase , BACE
T61969	AChE/BChE-IN-10		AChR , AChE
	AChE/BChE-IN-10 is a potent dual inhibitor of AChE and BChE with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 exhibits good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation...		AChR , AChE
T61439	DSS30		Beta Amyloid , BACE , CDK
	DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).DSS30 can be used for the prevention and tr...		Beta Amyloid , BACE , CDK
T22204	LY 2389575 hydrochloride		Beta Amyloid , GluR
	LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in the level of Mrc1, which amplifi...		Beta Amyloid , GluR

Compounds

Aβ-IN-1 TFA

T63208L

Synonym: Aβ-IN-1 TFA（2766509-32-2 Free base）

Target: Gamma-secretase

Aβ/tau aggregation-IN-1

Aβ Fibrillization modulator 1

Aβ/tau aggregation-IN-3

Protriptyline hydrochloride

T0204

Synonym: Protriptyline HCl

Target: 5-HT Receptor, AChE

MRK-560

T16133

Synonym:

Target: Gamma-secretase

7BIO

T22012

Synonym:

Target: FLT, DYRK, Aurora Kinase

3,5-Bis(4-nitrophenoxy)benzoic acid

T22678

Synonym: Compound W

Target: Gamma-secretase

Synonym: MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride

Target: Others, Antibacterial

Aβ42-IN-2

T9641

Synonym:

Target: Gamma-secretase

Beta-Sheet Breaker Peptide iAβ5 Acetate

T21609L

Synonym: Beta-Sheet Breaker Peptide iAβ5 Acetate(182912-74-9 Free base)

tau/Aβ40 aggregation-IN-1

T74811

Synonym:

Target:

Aβ1–42 aggregation inhibitor 1

Target: Beta Amyloid, Gamma-secretase, Microtubule Associated

Davunetide acetate

T21470L

Synonym: Davunetide acetate(211439-12-2 Free base)

Target: Beta Amyloid, Microtubule Associated

BMS 433796

T14690

Synonym: BMS-289948,BMS-299897

Target: Beta Amyloid, Gamma-secretase

GSNKGAIIGLM(131602-53-4(free base))

T7680

Synonym: Amyloid beta-peptide(25-35)

Target: Beta Amyloid, Gamma-secretase

FPS-ZM1

T3259

Synonym:

Target: Beta Amyloid, advanced glycation end products

β-Amyloid (25-35)

T14284

Synonym: β-Amyloid peptide(25-35),Aβ25-35,Amyloid beta-peptide(25-35)

Synonym: T-817MA,T-817 maleate

Target: Beta Amyloid

Atabecestat

T14338

Synonym: JNJ-54861911

Target: Beta Amyloid, Beta-Secretase, BACE, PI3K, Autophagy

Aftin-4

T4364

Synonym: Aftin 4,Aftin4

Target: Beta Amyloid, Gamma-secretase

DAPT

T6202

Synonym: LY-374973,GSI-IX

Target: Apoptosis, Beta Amyloid, Gamma-secretase, Autophagy

LY2811376

T2639

Synonym:

Target: Beta Amyloid, Beta-Secretase, BACE

Target: Beta Amyloid, BACE, CDK

LY 2389575 hydrochloride

T22204

Synonym:

Target: Beta Amyloid, GluR

Cat No.	Product Name	Synonyms	Targets
T5810	TABERSONINE HYDROCHLORIDE		Beta Amyloid
	TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.		Beta Amyloid
TMS1461	Qingyangshengenin B	Otophylloside B	Beta Amyloid
	Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mR...		Beta Amyloid
TN1216	2-O-Acetyl-20-hydroxyecdysone	20-Hydroxyeedysone 2-acetate	Beta Amyloid , Others
	2-O-Acetyl-20-hydroxyecdysone is an ecdysone present in insects and terrestrial plants. 2-O-Acetyl-20-hydroxyecdysone inhibits amyloid-β42-induced cytotoxicity and is able to reduce the formation of Aβ oligomers by promo...		Beta Amyloid , Others
T0883	Tramiprosate	Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed	Beta Amyloid , GABA Receptor
	Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GAB...		Beta Amyloid , GABA Receptor
T5S2129	Sciadopitysin		TNF , NF-κB
	Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in o...		TNF , NF-κB
T3246	Tabersonine	(-)-Tabersonine,Tabersonin	Others
	Tabersonine (Tabersonin)is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus.		Others
T3394	Timosaponin BII	Prototimosaponin A III	Beta Amyloid , Others , BACE
	Timosaponin BII (Prototimosaponin A III) has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-regulation of BACE1 and reduced the...		Beta Amyloid , Others , BACE
T32614	L-Clausenamide	(-)-Clausenamide	Microtubule Associated
	L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents t...		Microtubule Associated
T3S1873	Talatisamine		Potassium Channel
	1. Talatisamine (12 μM) and TEA (5mM) inhibits the enhanced I(K) caused by Aβ4 oligomers, attenuates cytotoxicity of Aβ oligomers by restoring cell viability and suppressing K(+) loss related apoptotic response. 2. Talat...		Potassium Channel
T3S0645	N-trans-Feruloyltyramine	Feruloyltyramine,N-Feruloyltyramine,Moupinamide	Others , COX
	1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s...		Others , COX
T2872	Ginsenoside Re	Ginsenoside B2,Panaxoside Re,Chikusetsusaponin Ivc,Sanchinoside Re	Beta Amyloid , NF-κB , Endogenous Metabolite , JNK
	Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.		Beta Amyloid , NF-κB , Endogenous Metabolite , JNK
T4956	Tetrahydroxystilbene-2-O-β-D-glucoside	tetrahydroxyl diphenylethylene-2-o-gluco,EH-201	Others
	Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astroc...		Others
T3769	Tenuifolin		Others , Beta-Secretase , AChE
	Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.		Others , Beta-Secretase , AChE
T2777	Ginsenoside Rg1	Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,Panaxoside A,Ginsenoside A2	Apoptosis , Beta Amyloid , NF-κB
	Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and increase hippocampal synaptophysin level i...		Apoptosis , Beta Amyloid , NF-κB
T22417	Rutin hydrate	Rutoside,Sophorin,Quercetin-3-O-rutinoside	Beta Amyloid , Others , Autophagy
	Rutin hydrate (Sophorin), a kind of glycoside, widely exists in many plants including citrus fruit.		Beta Amyloid , Others , Autophagy
T0795	Rutin	Quercetin 3-O-rutinoside,Rutoside	Beta Amyloid , Prostaglandin Receptor , Autophagy
	Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.		Beta Amyloid , Prostaglandin Receptor , Autophagy
T3402	20(S)-Ginsenoside Rg3	20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3	EGFR , Beta Amyloid , Potassium Channel , NF-κB , COX , Sodium Channel , Endogenous Metabolite
	20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial c...
T13967	Xanthocillin X permethyl ether		Others
	Xanthocillin X permethyl ether is a natural product isolated from fungal extracts, has Aβ-42 lowering activity.		Others
T37957	Setosusin
	Setosusin is a meroterpenoid fungal metabolite originally isolated from C. setosus. It reduces neurotoxicity induced by amyloid-β (Aβ) aggregates in PC12 cells (EC50 = 112.6 μM). In vivo, setosusin (30 mg/kg) induces tre...
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one		Beta Amyloid , PI3K , mTOR
	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's dise...		Beta Amyloid , PI3K , mTOR
T40641	Crocin-4
	Crocin-4, a carotenoid compound found in saffron, possesses potent antioxidant properties and can penetrate the brain. It effectively inhibits the aggregation and deposition of Aβ fibrils, making it useful for Alzheimer'...
T79994	7-Deoxy-trans-dihydronarciclasine
	7-Deoxy-trans-dihydronarciclasine is an alkaloid that functions as a tobacco mosaic virus (TMV) inhibitor with an IC50 of 1.80 μM and also serves as an anti-neuroinflammatory agent. This compound reduces Aβ and APP level...
TN3410	Anatabine		Beta Amyloid , IL Receptor , TNF , NF-κB , BACE , COX , STAT
	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheimer's disease effects, it inhibits BACE-1 transcription and r...

Natural Products

TABERSONINE HYDROCHLORIDE

Synonym: Otophylloside B

Target: Beta Amyloid

2-O-Acetyl-20-hydroxyecdysone

TN1216

Synonym: 20-Hydroxyeedysone 2-acetate

Target: Beta Amyloid, Others

Tramiprosate

T0883

Synonym: Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed

Target: Beta Amyloid, GABA Receptor

Synonym: (-)-Tabersonine,Tabersonin

Target: Others

Timosaponin BII

T3394

Synonym: Prototimosaponin A III

Target: Beta Amyloid, Others, BACE

L-Clausenamide

T32614

Synonym: (-)-Clausenamide

Target: Microtubule Associated

Talatisamine

T3S1873

Synonym:

Target: Potassium Channel

N-trans-Feruloyltyramine

T3S0645

Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide

Target: Others, COX

Ginsenoside Re

T2872

Synonym: Ginsenoside B2,Panaxoside Re,Chikusetsusaponin Ivc,Sanchinoside Re

Target: Beta Amyloid, NF-κB, Endogenous Metabolite, JNK

Tetrahydroxystilbene-2-O-β-D-glucoside

T4956

Synonym: tetrahydroxyl diphenylethylene-2-o-gluco,EH-201

Target: Others, Beta-Secretase, AChE

Ginsenoside Rg1

T2777

Synonym: Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,Panaxoside A,Ginsenoside A2

Target: Apoptosis, Beta Amyloid, NF-κB

Rutin hydrate

T22417

Synonym: Rutoside,Sophorin,Quercetin-3-O-rutinoside

Target: Beta Amyloid, Others, Autophagy

Rutin

T0795

Synonym: Quercetin 3-O-rutinoside,Rutoside

Target: Beta Amyloid, Prostaglandin Receptor, Autophagy

20(S)-Ginsenoside Rg3

T3402

Synonym: 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3

Target: EGFR, Beta Amyloid, Potassium Channel, NF-κB, COX, Sodium Channel, Endogenous Metabolite

Xanthocillin X permethyl ether

7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

TN3218

Synonym:

Target: Beta Amyloid, PI3K, mTOR

7-Deoxy-trans-dihydronarciclasine

Target: Beta Amyloid, IL Receptor, TNF, NF-κB, BACE, COX, STAT

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00851	IDE Protein, Human, Recombinant (His)	Human	Human Cells
	Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a r...
TMPY-00668	APP/Protease nexin-II Protein, Human, Recombinant (hFc)	Human	HEK293
	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-03884	Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST)	Human	E. coli
	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-03885	Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST)	Human	E. coli
	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-02110	Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST)	Human	E. coli
	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-02221	Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST)	Human	E. coli
	Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...

IDE Protein, Human, Recombinant (His)

TMPJ-00851

Species: Human

Expression System: Human Cells

APP/Protease nexin-II Protein, Human, Recombinant (hFc)

TMPY-00668

Species: Human

Expression System: HEK293

Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST)

TMPY-03884

Species: Human

Expression System: E. coli

Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST)

TMPY-03885

Species: Human

Expression System: E. coli

Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST)

TMPY-02110

Species: Human

Expression System: E. coli

Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST)

TMPY-02221

Species: Human

Expression System: E. coli

Cat No.	Product Name
L9840	Anti-Alzheimer's Disease Compound Library		986 compounds
	A unique collection of 986 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS.

Libraries

Anti-Alzheimer's Disease Compound Library

L9840

Compounds: 986