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L-Clausenamide

Catalog No. T32614 CAS 201529-58-0

Synonyms: (-)-Clausenamide

L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents the formation of neurofibrillary tangles by inhibiting tau phosphorylation. L-Clausenamide has neuroprotective activity and can be used to modulate stimuli triggered by Aβ25-35. L-Clausenamide can be used to study neurological disorders like Alzheimer's disease.

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L-Clausenamide, CAS 201529-58-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 397.00
5 mg	In stock	$ 970.00
10 mg	In stock	$ 1,180.00
25 mg	In stock	$ 1,580.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00

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Purity: 99.28%

ee: 98.43%

Purity: 99.05%

ee: 98.85%

Biological Description

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Description

In vitro

Reversing the overload in [Ca2+]i level stimulated by Aβ25-35 and reducing Aβ-mediated cell apoptosis in PC12 cells, (-)Clausenamide (10 and 100 μM) demonstrates its protective effects[3].
In Aβ25-35-treated PC12 cells, (-)Clausenamide (10 and 100 μM) inhibits the phosphorylation of p38 MAPK and down-regulates the expression of P53 and cleaved Caspase-3, as well as the ratio of Bax/Bcl-2[3].

Synonyms	(-)-Clausenamide
Molecular Weight	297.35
Formula	C18H19NO3
CAS No.	201529-58-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Chu S, Liu S, Duan W, et al. The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect. Pharmacol Ther. 2016;162:179-187. 2. Chu SF, Zhang JT. Recent advances in the study of (-)clausenamide: chemistry, biological activities and mechanism of action. Acta Pharm Sin B. 2014;4(6):417-423. 3. Hu JF, et al. Protective effect of (-)clausenamide against Abeta-induced neurotoxicity in differentiated PC12 cells. Neurosci Lett. 2010 Oct 8;483(1):78-82.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

L-Clausenamide 201529-58-0 Cytoskeletal Signaling Microtubule Associated Clausenamide (-)-Clausenamide inhibitor inhibit

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