Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ 1-42 β-sheet formation and tau aggregation. It exhibits K D values of 160 μM and 337 μM with Aβ 1-42 and tau, respectively. Additionally, Aβ/tau aggregation-IN-1 can penetrate the blood-brain barrier efficiently.
Description | Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ 1-42 β-sheet formation and tau aggregation. It exhibits K D values of 160 μM and 337 μM with Aβ 1-42 and tau, respectively. Additionally, Aβ/tau aggregation-IN-1 can penetrate the blood-brain barrier efficiently. |
Targets&IC50 | β-Amyloid (1–42):160 μM (Kd), Tau:337 μM (Kd) |
In vitro | Aβ/tau aggregation-IN-1 (1 μM; 24 hours; HEK-293 T cells) markedly reduces the number of tau aggregation foci. By incorporating N-methylation on the quinolone ring, this compound robustly inhibits the aggregation of Aβ 1-42 (by 84.7%–99.5%) and tau (by 71.2%–101.8%). It prevents self-induced Aβ 1-42 aggregation by blocking β-sheet formation and demonstrates notable affinity for both Aβ 1-42 and tau, with dissociation constants (K_D) of 160 μM and 337 μM, respectively. This interaction with Aβ 1-42 and tau is mediated via noncovalent bonds. Furthermore, immunofluorescence assays in HEK-293 T cells confirm its efficacy in significantly reducing tau aggregation foci. |
Molecular Weight | 492.36 |
Formula | C25H21IN2O |
CAS No. | 2252162-81-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Aβ/tau aggregation-IN-1 2252162-81-3 Aβ/tau aggregation IN 1 Ab/tau aggregation-IN-1 Abeta/tau aggregation-IN-1 Aβ/tau aggregationIN1 inhibitor inhibit