Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 589.00 | |
500 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion. |
In vitro | ARN2966 reduces levels of APP and its intracellular C-terminal fragments α-CTF and β-CTF in CHO APP751SW cells when used at a concentration of 10 μM. ARN2966?also reduces?secretion of Aβ (1-40) and Aβ (1-42) by 88.6 and 84.9%, respectively. |
In vivo | In vivo,ARN2966? reduces brain levels of full-length APP, α-CTF and β-CTF, and soluble Aβ (1-40) and Aβ (1-42) in the APPSWPS1dE9 transgenic mouse model of Alzheimer's disease.?It also improves novel object memory as well as spatial memory in the radial arm maze in APPSWPS1dE9 transgenic mice. |
Molecular Weight | 200.24 |
Formula | C12H12N2O |
CAS No. | 102212-26-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 43.4 mg/mL (216.74 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ARN2966 102212-26-0 Neuroscience Beta Amyloid β-amyloid peptide inhibit Abeta Inhibitor Amyloid-β ARN 2966 ARN-2966 inhibitor