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β-Amyloid (25-35)

Catalog No. T14284 CAS 131602-53-4

Synonyms: β-Amyloid peptide(25-35), Aβ25-35, Amyloid beta-peptide(25-35)

β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.

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β-Amyloid (25-35), CAS 131602-53-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
5 mg	In stock	$ 189.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 519.00
50 mg	In stock	$ 752.00
100 mg	In stock	$ 1,060.00

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Purity: 97.91%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.
In vitro	The amino acid sequence of Aβ(25-35) peptide is NH2-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-COOH, where the first Gly represents the amino acid 25 and the last Met represents the amino acid 35 and it is also investigated in gel state for the first time. Amyloid beta-peptide(25-35) induces apoptotic effects on isolated brain mitochondria and the redox state of methionine-35, plays a key role in the induction of programmed cellular death pathways and toxic events[2]. Comparative studies are also carried out using vibrational absorption and ECD. The conformational preference of Aβ(25-35) peptide film is also investigated using vibrational absorption and VCD spectroscopy[1].
In vivo	The Alzheimer' s disease (AD) model group present with spatial learning and memory impairments. CDS and donepezil administration significantly ameliorate the Aβ25–35 peptide-induced memory impairment in both Morris water maze (P?

Synonyms	β-Amyloid peptide(25-35), Aβ25-35, Amyloid beta-peptide(25-35)
Molecular Weight	1060.27
Formula	C45H81N13O14S
CAS No.	131602-53-4

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 3.33 mg/mL (3.14 mM), Sonication is recommended.

DMSO: 97 mg/mL (91.49 mM), Sonication is recommended.

References and Literature

1. D'Ursi AM, et al. Solution structure of amyloid beta-peptide (25-35) in different media. J Med Chem. 2004 Aug 12;47(17):4231-8. 2. Clementi ME, et al. Abeta(31-35) and Abeta(25-35) fragments of amyloid beta-protein induce cellular death throughapoptotic signals: Role of the redox state of methionine-35. FEBS Lett. 2005 May 23;579(13):2913-8. 3. Liu M, et al. Cognitive improvement of compound danshen in an Aβ25-35 peptide-induced rat model of Alzheimer's disease. BMC Complement Altern Med. 2015 Oct 23;15:382.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library Neuronal Signaling Compound Library Human Metabolite Library Bioactive Compounds Library Max Anti-Alzheimer's Disease Compound Library Bioactive Compound Library

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Keywords

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