Home Tools
Log in
Cart

Sciadopitysin

Catalog No. T5S2129   CAS 521-34-6

Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in osteoblastic MC3T3-E1 cells, it may reduce or prevent osteoblasts degeneration.Sciadopitysin can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Sciadopitysin Chemical Structure
Sciadopitysin, CAS 521-34-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 44.00
5 mg In stock $ 96.00
10 mg In stock $ 165.00
25 mg In stock $ 319.00
50 mg In stock $ 479.00
100 mg In stock $ 688.00
500 mg In stock $ 1,420.00
1 mL * 10 mM (in DMSO) In stock $ 132.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.17%
Purity: 99.02%
Purity: 98.67%
Purity: 98.14%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in osteoblastic MC3T3-E1 cells, it may reduce or prevent osteoblasts degeneration.Sciadopitysin can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons.
Cell Research Pretreatment of MC3T3-E1 cells with Sciadopitysin prevented the MG-induced cell death and protein adducts formation. Sciadopitysin restored the MG-induced change in glyoxalase activity almost to the control level and increased glutathione levels. In addition, Sciadopitysin decreased MG-induced formation of intracellular reactive oxygen species (ROS), mitochondrial superoxide, and cardiolipin peroxidation. These findings suggest that Sciadopitysin provides a protective action against MG-induced glycation by increasing MG detoxification system and by reducing oxidative stress. Pretreatment with Sciadopitysin prior to MG exposure reduced MG-induced mitochondrial dysfunction by preventing mitochondrial membrane potential (MMP) dissipation and adenosine triphosphate (ATP) loss.
Source
Molecular Weight 580.54
Formula C33H24O10
CAS No. 521-34-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (111.96 mM)

TargetMolReferences and Literature

1. Choi EM, et al.Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis.Free Radic Res. 2014 Jul;48(7):729-39. 2. Suh KS, et al.Sciadopitysin protects osteoblast function via its antioxidant activity in MC3T3-E1 cells.Sciadopitysin protects osteoblast function via its antioxidant activity in MC3T3-E1 cells. 3. Gu Q, et al.Sciadopitysin: active component from Taxus chinensis for anti-Alzheimer's disease.Nat Prod Res. 2013;27(22):2157-60.

TargetMolCitations

1. Xiao Y, Cai G P, Feng X, et al.Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.The EMBO Journal.2023: e111762.

Related compound libraries

This product is contained In the following compound libraries:
Chinese Pharmacopoeia Natural Product Library Inhibitor Library Anti-Breast Cancer Compound Library Cytokine Inhibitor Library Bioactive Compounds Library Max Anti-Prostate Cancer Compound Library Natural Product Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Apoptosis Compound Library Selected Plant-Sourced Compound Library

Related Products

Related compounds with same targets
Isorhamnetin 3-O-galactoside Sappanone A Sanggenon C Benzoyloxypaeoniflorin Latifolin Caffeic Acid Phenethyl Ester Cheilanthifoline Zingerone

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sciadopitysin 521-34-6 Apoptosis NF-Κb TNF NF-κB Biflavonoids biloba osteoclastogenesis Nuclear factor-κB loss Inhibitor inhibit bone ginkgo Nuclear factor-kappaB inhibitor

 

TargetMol