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Atabecestat

Catalog No. T14338 CAS 1200493-78-2

Synonyms: JNJ-54861911

Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Atabecestat, CAS 1200493-78-2

Pack Size	Availability	Price/USD	Quantity
1 mg	5 days	$ 148.00
1 mL * 10 mM (in DMSO)	5 days	$ 456.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	JNJ-54861911
Molecular Weight	367.4
Formula	C18H14FN5OS
CAS No.	1200493-78-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 250 mg/mL (680.46 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Timmers M, et al. Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor.Alzheimers Dement (N Y). 2016 Aug 24;2(3):202-212.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Atabecestat 1200493-78-2 Neuroscience BACE JNJ-54861911 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.