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Atabecestat
🥰Excellent
Catalog No. T14338Cas No. 1200493-78-2
Alias RSC-385896, JNJ-54861911
Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor that achieves robust and high CSF Aβ reduction, is well-tolerated, and displays sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].
Atabecestat
🥰Excellent
Purity: 99.77%
Catalog No. T14338Alias RSC-385896, JNJ-54861911Cas No. 1200493-78-2
Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor that achieves robust and high CSF Aβ reduction, is well-tolerated, and displays sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $132 | In Stock | |
| 5 mg | $328 | In Stock | |
| 10 mg | $529 | In Stock | |
| 25 mg | $1,060 | In Stock | |
| 50 mg | $1,420 | In Stock | |
| 100 mg | $1,920 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $363 | In Stock |
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Purity:99.77%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor that achieves robust and high CSF Aβ reduction, is well-tolerated, and displays sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1]. |
| In vivo | In 5-week-old APPPS1 mice, Atabecestat (100 and 300 mg/kg; oral gavage; once daily for 3 days) reduced the levels of human Aβ1-40 and Aβ1-42 in the brain of APPPS1 mice at a dose of 300 mg/kg, and resulted in less reduction of human Aβ levels at 24 hours with a dose of 100 mg/kg[2]. |
| Alias | RSC-385896, JNJ-54861911 |
| Molecular Weight | 367.4 |
| Formula | C18H14FN5OS |
| Cas No. | 1200493-78-2 |
| Smiles | C[C@]1(C=CSC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F |
| Relative Density. | 1.39 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200 mg/mL (544.37 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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