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Atabecestat

Name: Atabecestat
Brand: TargetMol
SKU: T14338
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14338Cas No. 1200493-78-2

Alias RSC-385896, JNJ-54861911

Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor that achieves robust and high CSF Aβ reduction, is well-tolerated, and displays sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].

Atabecestat

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Purity: 99.77%

Catalog No. T14338Alias RSC-385896, JNJ-54861911Cas No. 1200493-78-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$529	In Stock	In Stock
25 mg	$1,060	In Stock	In Stock
50 mg	$1,420	In Stock	In Stock
100 mg	$1,920	-	In Stock
1 mL x 10 mM (in DMSO)	$363	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.77%

Appearance:Solid

Color:Yellow

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COA LCMS

Product Introduction

Bioactivity

Description	Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor that achieves robust and high CSF Aβ reduction, is well-tolerated, and displays sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].
In vivo	In 5-week-old APPPS1 mice, Atabecestat (100 and 300 mg/kg; oral gavage; once daily for 3 days) reduced the levels of human Aβ1-40 and Aβ1-42 in the brain of APPPS1 mice at a dose of 300 mg/kg, and resulted in less reduction of human Aβ levels at 24 hours with a dose of 100 mg/kg[2].
Synonyms	RSC-385896, JNJ-54861911

Chemical Properties

Molecular Weight	367.4
Formula	C₁₈H₁₄FN₅OS
Cas No.	1200493-78-2
Smiles	C[C@]1(C=CSC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (544.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7218 mL	13.6091 mL	27.2183 mL	136.0915 mL
5 mM	0.5444 mL	2.7218 mL	5.4437 mL	27.2183 mL
10 mM	0.2722 mL	1.3609 mL	2.7218 mL	13.6091 mL
20 mM	0.1361 mL	0.6805 mL	1.3609 mL	6.8046 mL
50 mM	0.0544 mL	0.2722 mL	0.5444 mL	2.7218 mL
100 mM	0.0272 mL	0.1361 mL	0.2722 mL	1.3609 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc