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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2253 | TCS PIM-1 1 | SC 204330 | Pim |
TCS PIM-1 1 (SC 204330)(sc-204330) is a effective and specific ATP-competitive Pim-1 kianse inhibitor (IC50: 50 nM) , exhibits good specific over MEK1/MEK2 and Pim-2(IC50s >20, 000 nM). | |||
T4215 | TCS-PIM-1-4a | SMI-4a | Apoptosis , Pim |
TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM). | |||
T9229 | Pim-1/2 kinase inhibitor 1 | Pim | |
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim ... | |||
T77526 | Pim-1 kinase inhibitor 4 | Apoptosis , Pim | |
Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity and potential anticancer activity, and inhibits DPPH.Pim-1 kinase in... | |||
T83627 | Pim-1 kinase inhibitor 8 | Pim , PKC | |
Pim-1 kinase inhibitor 8 is a potent Pim-1 kinase inhibitor with anticancer activity and can effectively inhibit cell migration.Pim-1 kinase inhibitor 8 is cytotoxic to MCF-7 and HepG2 cells, and is a candidate compound ... | |||
T3058 | (Z)-SMI-4a | TCS PIM-1 4a,SMI-4a | Pim |
(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM. | |||
T40319 | PIM-IN-1 | ||
PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM). | |||
T3078 | SGI-1776 | SGI-1776 free base,Pim-Kinase Inhibitor IX | Apoptosis , FLT , Pim , Autophagy |
SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias. | |||
T6148 | CX-6258 hydrochloride | CX-6258 HCl,Pim-Kinase Inhibitor X | Pim |
CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM). | |||
T40092 | MNK/PIM-IN-1 | ||
MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile. | |||
T12473 | PIM-447 dihydrochloride | LGH447 dihydrochloride | Others |
PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively). | |||
T23158 | PIM-1 Inhibitor 2 | Others | |
PIM-1 Inhibitor 2 is an effective Pim-1 kinase inhibitor (Ki = 91 nM). | |||
T71558 | Pim-IN-14j | ||
Pim-IN-14j is a potent, highly selective, and orally bioavailable inhibitor of PIM-1 kinases. | |||
T81460 | PIM-IN-2 | Pim | |
PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM . It exhibits antiapoptotic properties conducive to cell survival and has been found to ... | |||
T4523 | TP-3654 | Pim | |
TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM). | |||
T62001 | Pim-1 kinase inhibitor 2 | ||
Pim-1 kinase inhibitor 2 (Compound 13), a potent inhibitor of Pim-1 kinase, has the potential for cancer research due to its ability to induce apoptosis [1]. | |||
T78980 | Pim-1 kinase inhibitor 5 | Pim | |
Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-116, with IC50 values ranging from 6.95 to 20.19 μM [1]. | |||
T61074 | Pim-1 kinase inhibitor 3 | ||
Pim-1 kinase inhibitor 3 (Compound H5) is a potent inhibitor of Pim-1 kinase, demonstrating an inhibitory concentration (IC50) of 35.13 nM [1]. | |||
T60972 | Pim-1 kinase inhibitor 1 | ||
Pim-1 kinase inhibitor 1 can be used in cancer research, showing anticancer activity against a variety of cancer cell lines by promoting cell apoptosis. Pim-1 kinase inhibitor 1 is an inhibitor of Pim-1 kinase with an IC... | |||
T61510 | PIM-1/HDAC-IN-1 | ||
PIM-1/HDAC-IN-1 (compound 4d) is a potent inhibitor of PIM-1, with an IC 50 of 343.87 nM. It also exhibits strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC 50 values of 63.65 and 62.39 nM, re... | |||
T2300 | AZD1208 | Apoptosis , Pim , Autophagy | |
AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases. | |||
T1834 | CX-6258 | CX 6258 | Pim |
CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity. | |||
T5093 | Pim1/AKK1-IN-1 | LKB1/AAK1 dual inhibitor,MDK-2275 | Pim , Hippo pathway |
Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK. | |||
T3989 | SMI-16a | PIM1/2 Kinase Inhibitor VI | Pim |
SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM) while exhibiting little or no activity against... | |||
T12477 | Uzansertib phosphate | INCB053914 phosphate | Pim |
Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively). | |||
T12475 | PIM447 | LGH447 | Others |
PIM447 is a potent, orally available, and selective inhibitor of pan-PIM kinase(PIM1, PIM2, and PIM3 with Ki values of 6, 18, and 9 pM , respectively). | |||
T15376 | GDC-0339 | Pim | |
GDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 is an orally bioavailable and well-tolerated inhibitor of pan-Pim kinase (Kis: 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respective... | |||
T13425 | (1S,3R,5R)-PIM447 dihydrochloride | (1S,3R,5R)-LGH447 dihydrochloride | CDK |
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3). | |||
T24166 | Inecalcitol | TX 522,TX-522,TX522 | Apoptosis |
Inecalcitol (TX 522) is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM. | |||
T71556 | MK-1496 | ||
MK1496 is a n orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apop... | |||
T12474 | PIM1-IN-1 | Pim | |
PIM1-IN-1 is a potent and highly selective inhibitor of PIM1/3(IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively),with Antiproliferative and anti-cancer activity. | |||
T6297 | Alvespimycin hydrochloride | BMS 826476,NSC 707545,KOS-1022,17-DMAG hydrochloride,Alvespimycin (17-DMAG) HCl | Apoptosis , HSP |
Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2. | |||
T37979 | N-Desmethyl Pimavanserin | AC-279 | 5-HT Receptor |
N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin, a 5-HT2A receptor inverse agonist, which is used in the treatment of sleep disorders such as insomnia. | |||
T2076 | Pimavanserin | ACP-103 | 5-HT Receptor |
Pimavanserin (ACP-103)(ACP-103) is an effective and specific 5-HT2A receptor inverse agonist (mean pIC50: 8.7, in the cell-based functional assay). Pimavanserin is an atypical antipsychotic used in the treatment of hallu... | |||
T12871 | Talmapimod | SCIO-469 | p38 MAPK |
Talmapimod (SCIO-469) is an selective, orally active, and ATP-competitive p38α inhibitor with IC50 of 9 nM and 90 nM for p38α and p38β, respectively. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 ... | |||
T2675 | Bentamapimod | AS 602801 | JNK |
Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK. | |||
T2277 | Losmapimod | GSK-AHAB,GW856553X,GW856553,SB856553 | p38 MAPK , Autophagy |
Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β). | |||
T6277 | Doramapimod | BIRB 796 | Raf , p38 MAPK , Autophagy |
Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70. | |||
T4377 | Pimodivir | VX-787 | Influenza Virus |
Pimodivir (VX-787), an influenza A virus polymerases inhibitor via oral, interacts with the viral PB2 subunit. | |||
T1162 | Acipimox | Olbemox,K-9321 | Others |
Acipimox (K-9321) is a niacin derivative and nicotinic acid analog with activity as a hypolipidemic agent. Acipimox has special application for the treatment of hyperlipidemia in non-insulin-dependent diabetic patients. | |||
T1708 | Pimobendan | Acardi,Pimobendane,UD-CG 115 BS,UD-CG115 | PDE |
Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM). | |||
T16994 | Pimitespib | TAS-116 | HSP |
Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively). | |||
T12489 | Pimethixene | Calmixen,Pimetixene | Dopamine Receptor , 5-HT Receptor , AChR , Histamine Receptor |
Pimethixene (Calmixen) is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 ... | |||
T6131 | Pimasertib | AS703026,MSC1936369B,SAR 245509 | MEK |
Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. | |||
T12489L | Pimethixene maleate | Pimetixene maleate | Dopamine Receptor , 5-HT Receptor , AChR , Histamine Receptor |
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as we... | |||
T16537 | Pimonidazole | Others | |
Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative assessment of... | |||
T2648 | Pimecrolimus | SDZ-ASM 981,ASM 981 | Others |
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri... | |||
T3193 | Pimelic diphenylamide 106 | Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8 | HDAC |
Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively), showing no activity against class II HDACs. | |||
T8920 | Sepimostat | iGluR | |
Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki v... | |||
T18363 | Monoethyl pimelate | Others , PROTAC Linker | |
Monoethyl pimelate is a <b >PROTAC linker, which refers to the alkyl/ether composition. Monoethyl pimelate can be used in the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader[1]. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TQ0201 | Hispidulin | Dinatin | Pim |
Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM). | |||
T8114 | Quercetagetin | 6-Hydroxyquercetin | Pim |
Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM). | |||
T4593 | ISOPIMPINELLIN | 5,8-Dimethoxypsoralen,4,9-Dimethoxypsoralen | Antiviral , DNA/RNA Synthesis , Parasite |
Isopimpinellin (4,9-Dimethoxypsoralen) is a natural product isolated from the roots of Pimpinella saxifrage with antiviral and antileishmanial activity. | |||
T5S2139 | Epimedin A1 | Hexandraside F | Others |
Epimedin A1 (Hexandraside F)(Hexandraside F) is a flavonoid extracted from Herba Epimedii which is one of commonly used Chinese medicines. | |||
TN1610 | Epimagnolin A | Parasite | |
Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion. | |||
T4795 | Pimelic acid | Pileric acid,1,7-Heptanedioic acid,1,5-Pentanedicarboxylic acid | Others , Endogenous Metabolite |
Derivatives of Pimelic acid (1,5-Pentanedicarboxylic acid) can participate in the biosynthesis of lysine. | |||
TN3972 | Epimedokoreanin B | Apoptosis , Others , Antibacterial | |
Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-... | |||
T5776 | pimpinellin | Apoptosis , Anti-infection | |
Pimpinellin is a natural product that acts as antagonist of proteins with GABA receptor activity. | |||
T6S2146 | Epimedin B | Epmedin B | Others |
1. Epimedin B (Epmedin B) has potential activity against osteoporosis by stimulating osteoblasts. | |||
T6290 | Tanespimycin | 17-AAG,CP 127374,NSC 330507,KOS 953 | Apoptosis , Mitophagy , HSP , Antibacterial , Antibiotic , Autophagy |
Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM). | |||
T3906 | Epimedin A | Others | |
Epimedin A has anti-osteoporosis activities in vivo. | |||
TN1611 | Epimedoside A | Others | |
Epimedoside A has significant antioxidant activity in vitro. | |||
TN3935 | Ent-14,16-Epoxy-8-pimarene-3,15-diol | Others | |
ent-14,16-Epoxy-8-pimarene-3,15-diol is a natural product for research related to life sciences. The catalog number is TN3935 and the CAS number is 1188281-98-2. | |||
TN6294 | 2α-Acetoxy-14,15-cyclopimara-7β,16-diol | ||
2α-Acetoxy-14,15-cyclopimara-7β,16-diol is a natural product for research related to life sciences. The catalog number is TN6294 and the CAS number is 2011034-27-6. | |||
TN5662 | Epimedonin I | ||
Epimedonin I is a natural product for research related to life sciences. The catalog number is TN5662 and the CAS number is 2222285-83-6. | |||
TN5953 | 3-Epimeliasenin B | ||
3-Epimeliasenin B is a natural product for research related to life sciences. The catalog number is TN5953 and the CAS number is 1222475-77-5. | |||
TN3261 | 8(14),15-Isopimaradiene-3,18-diol | Others | |
8(14),15-Isopimaradiene-3,18-diol is a natural product for research related to life sciences. The catalog number is TN3261 and the CAS number is 59219-64-6. | |||
TN2639 | 15-Isopimarene-8,18-diol | Others | |
15-Isopimarene-8,18-diol is a natural product for research related to life sciences. The catalog number is TN2639 and the CAS number is 73002-86-5. | |||
TN5663 | Epimedonin J | ||
Epimedonin J is a natural product for research related to life sciences. The catalog number is TN5663 and the CAS number is 2222285-84-7. | |||
TN3260 | 8(14),15-Isopimaradien-3-ol | Calcium Channel , Antifection | |
ent-8(14),15-pimaradien-3beta-ol (8(14),15-Isopimaradien-3-ol) can induce vascular relaxation. It displays high antibacterial activities (MIC values lower than 10 microg /mL for most pathogens). | |||
TN2611 | 13-Epimanool | Others | |
13-Epimanool is a natural product of Salvia, Lamiaceae. The catalog number is TN2611 and the CAS number is 1438-62-6. 13-Epimanool can be used as a reference standard. | |||
TN3970 | Epimedin B1 | Others | |
Epimedin B1 is a natural product for research related to life sciences. The catalog number is TN3970 and the CAS number is 133137-58-3. | |||
TN5667 | Epimedonin G | ||
Epimedonin G is a natural product for research related to life sciences. The catalog number is TN5667 and the CAS number is 2222285-80-3. | |||
TN1009 | Epimagnolin B | NF-κB , NO Synthase , Prostaglandin Receptor | |
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear transl... | |||
TN5664 | Epimedonin K | ||
Epimedonin K is a natural product for research related to life sciences. The catalog number is TN5664 and the CAS number is 2222285-85-8. | |||
TN5468 | Epimedonin L | ||
Epimedonin L is a natural product for research related to life sciences. The catalog number is TN5468 and the CAS number is 2215102-38-6. | |||
TN3971 | Epimedin K | Others | |
Epimedin K is a natural product from Epimedium koreanum NAKAI (Berberidaceae). | |||
T82027 | Isopimarol acetate | ||
Isopimarol acetate, a natural product, is identified in the plant Nepeta tuberosa subsp. reticulata [1]. | |||
TN2075 | Pimaric acid | MMP , p38 MAPK , NF-κB | |
Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human aortic smooth muscle cells. | |||
TN1835 | Epimedoside | Korepimedoside A | Others |
Korepimedoside A is a natural product from Epimedium koreanum. | |||
T39445 | Korepimedoside C | Epimedin I | |
Korepimedoside C, also known as Epimedin I, is a flavonol glycoside derived from the aerial parts of Epimedium koreanum Nakai. Epimedium koreanum Nakai is a renowned Chinese herbal medicine that has been extensively stud... | |||
TN5659 | 7-O-Methylepimedonin G | ||
7-O-Methylepimedonin G is a natural product for research related to life sciences. The catalog number is TN5659 and the CAS number is 2220243-40-1. | |||
TN4319 | Isopimaric acid | Antifection | |
Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also poss... | |||
TN5668 | Epimedonin H | ||
Epimedonin H is a natural product for research related to life sciences. The catalog number is TN5668 and the CAS number is 2222285-82-5. |