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PIM1-IN-1

Name: PIM1-IN-1
Brand: TargetMol
SKU: T12474
Price: 126 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12474Cas No. 1417630-95-5

PIM1-IN-1 is a potent and highly selective PIM kinase inhibitor with strong preference for PIM1 and PIM3 over PIM2, effectively inhibiting BAD phosphorylation without detectable effects on FLT3 or hERG binding, and exhibiting antiproliferative and anticancer activity suitable for mechanistic studies of PIM-driven oncogenic signaling.

PIM1-IN-1

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Purity: 98.59%

Catalog No. T12474Cas No. 1417630-95-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$126	-	In Stock
5 mg	$313	-	In Stock
10 mg	$496	-	In Stock
25 mg	$953	-	In Stock
1 mL x 10 mM (in DMSO)	$345	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.59%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PIM1-IN-1 is a potent and highly selective PIM kinase inhibitor with strong preference for PIM1 and PIM3 over PIM2, effectively inhibiting BAD phosphorylation without detectable effects on FLT3 or hERG binding, and exhibiting antiproliferative and anticancer activity suitable for mechanistic studies of PIM-driven oncogenic signaling.
Targets&IC50	Pim1:7 nM, Pim3:70 nM, Pim2:5530 nM
In vitro	In the SKMEL-19 melanoma cell line, PIM1-IN-1 inhibited cell growth with a GI50 value of 1.48 μM. When cells were treated at concentrations of 2.5, 5, and 10 μM for 24 hours, the compound dose-dependently induced apoptosis[1].
In vivo	PIM1-IN-1 demonstrates acceptable clearance of 1.26 L/h/kg in BALB-C mice[1].

Chemical Properties

Molecular Weight	474.56
Formula	C₂₅H₃₀N₈O₂
Cas No.	1417630-95-5
Smiles	N=1N=C2C=3OCCN(C3C=NN2C1C4=NC=5C(=CC=CC5NCC6CCNCC6)C=C4)CCOC
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 36 mg/mL (75.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1072 mL	10.5361 mL	21.0722 mL	105.3608 mL
5 mM	0.4214 mL	2.1072 mL	4.2144 mL	21.0722 mL
10 mM	0.2107 mL	1.0536 mL	2.1072 mL	10.5361 mL
20 mM	0.1054 mL	0.5268 mL	1.0536 mL	5.2680 mL
50 mM	0.0421 mL	0.2107 mL	0.4214 mL	2.1072 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc