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Pimecrolimus

Catalog No. T2648 CAS 137071-32-0

Synonyms: SDZ-ASM 981, ASM 981

Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin.

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Pimecrolimus, CAS 137071-32-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 34.00
10 mg	In stock	$ 54.00
25 mg	In stock	$ 63.00
50 mg	In stock	$ 72.00
100 mg	In stock	$ 127.00
200 mg	In stock	$ 189.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.53%

Purity: 98.89%

Purity: 98.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin.
In vitro	Pimecrolimus effectively alleviates allergic symptoms in a variety of (allergic) animals. Within the context of both the acute allergic dermatitis low-magnesium hairless rat model and the moderate allergic contact dermatitis mouse model, Pimecrolimus inhibits inflammatory responses and pruritic (itching) symptoms.
In vivo	In mast cells, Pimecrolimus inhibits the transcription and synthesis of cytokines, while simultaneously promoting the release of 5-hydroxytryptamine and β-hexosaminidase. In T lymphocytes, Pimecrolimus suppresses activation by inhibiting phosphatase activity, thereby blocking T-cell activation.

Synonyms	SDZ-ASM 981, ASM 981
Molecular Weight	810.45
Formula	C43H68ClNO11
CAS No.	137071-32-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (114.8 mM)

DMSO: 93 mg/mL (114.8 mM)

References and Literature

1. Nghiem P, et al. Am Acad Dermatol, 2002, 46(2), 228-241. 2. Gupta AK, et al. J Eur Acad Dermatol Venereol, 2003, 17(5), 493-503. 3. Stuetz A, et al. Semin Cutan Med Surg, 2001, 20(4), 233-241.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Bioactive Compound Library Human Metabolite Library NO PAINS Compound Library Clinical Compound Library Covalent Inhibitor Library FDA-Approved & Pharmacopeia Drug Library Approved Drug Library FDA-Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pimecrolimus 137071-32-0 Others mast cells T-cells SDZ-ASM 981 ASM-981 ASM 981 atopic dermatitis oral erosive lichen planus Phosphatase Inhibitor inhibit SDZ-ASM981 anti-inflammatory orally active inflammatory skin diseases SDZ-ASM-981 ASM981 inhibitor

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