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Epimedokoreanin B
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Synonyms:
Catalog No. TN3972 Copy Product Info
Purity: 99.75%
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Epimedokoreanin B is a natural isopentenylflavonoid compound isolated from Korean horny goat weed (Epimedium koreanum Nakai) that exhibits anticancer, anti-inflammatory, and antibacterial activities. Epimedokoreanin B is an anti-periodontitis agent that inhibits the growth and biofilm formation of gingival proteases and Porphyromonas gingivalis. Epimedokoreanin B can inhibit the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagy.
Cas No. 161068-53-7
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $147 | In Stock | In Stock | |
| 5 mg | $368 | In Stock | In Stock | |
| 10 mg | $543 | - | In Stock | |
| 25 mg | Preferential | - | In Stock | |
| 50 mg | Preferential | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $417 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:99.75%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Epimedokoreanin B is a natural isopentenylflavonoid compound isolated from Korean horny goat weed (Epimedium koreanum Nakai) that exhibits anticancer, anti-inflammatory, and antibacterial activities. Epimedokoreanin B is an anti-periodontitis agent that inhibits the growth and biofilm formation of gingival proteases and Porphyromonas gingivalis. Epimedokoreanin B can inhibit the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagy. |
| Targets & IC50 | HNE:6.06 μM, Bacterial Nucleic Acid:0.17 µM |
| In vitro | Methods: Human myeloma cells U266 and RPMI-8226 were treated with Epimedokoreanin B at gradient concentrations (5, 10, 15 μM) for 48 hours. Apoptosis was assessed via Annexin V/PI double staining. Results: Cells exhibited concentration-dependent apoptosis induction. At 15 μM, the apoptosis rate reached 62.2% in U266 cells and 51.81% in RPMI-8226 cells. [1] Methods: Human osteosarcoma cells (Saos-2) and mouse osteosarcoma cells (LM8) were treated with Epimedokoreanin B at gradient concentrations (5, 10, 20 μM) for 48–72 hours. Proliferation was assessed using MTT assay or cell counting. Results: Concentration-dependent inhibition of proliferation was observed in both osteosarcoma cell lines, accompanied by decreased STAT3 phosphorylation levels. [2] |
| In vivo | Methods: LM8 mouse osteosarcoma cells were subcutaneously implanted into C3H mice to establish a tumor model. Once tumors became palpable, Epimedokoreanin B oral gavage administration commenced at doses of 10 mg/kg or 30 mg/kg, once daily for 14 consecutive days. Results: Tumor growth was significantly slowed, with marked reductions in tumor volume and weight observed in both dose groups.[2] |
| Molecular Weight | 422.47 |
| Formula | C25H26O6 |
| Cas No. | 161068-53-7 |
| Smiles | C(C=C(C)C)C1=C2C(C(=O)C=C(O2)C3=CC(CC=C(C)C)=C(O)C(O)=C3)=C(O)C=C1O |
| Relative Density. | 1.301 g/cm3 (Predicted) |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 33.33 mg/mL (78.89 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Related Tags: Epimedokoreanin B chemical structure | Epimedokoreanin B in vivo | Epimedokoreanin B in vitro | Epimedokoreanin B formula | Epimedokoreanin B molecular weight
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