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Pimaric acid

Catalog No. TN2075 CAS 127-27-5

Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human aortic smooth muscle cells.

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Pimaric acid, CAS 127-27-5

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Description	Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human aortic smooth muscle cells.
In vitro	Down-regulated MMP-9 mRNA transcription was detected in Pimaric acid-treated cells using RT-PCR and the luciferase-tagged MMP-9 promoter assay. Results of an electrophoretic mobility shift assay indicated that Pimaric acid-treated HASMCs showed decreased binding activity of nuclear factor (NF)-κB and activator protein-1 transcription factors. A Western-blot analysis using nuclear extract demonstrated that Pimaric acid reduced the levels of NF-κB p65, c-Fos, p-c-Jun, Jun-D, and p-ATF2 proteins in the nucleus. In addition, TNF-α± stimulated mitogen activated protein kinase (MAPK) containing extracellular signal regulated kinase 1 and 2, p38, and c-Jun N-terminal kinase was inhibited by Pimaric acid. Using the Transwell system, we found that Pimaric acid inhibited TNF-α± stimulated HASMC migration/invasion in a dose-dependent manner. To confirm whether MAPK mediated MMP-9 expression, we used MAPK inhibitors including U0126, SB253580, and SP600125 and found that those inhibitors reduced MMP-9 expression and HASMC migration/invasion[1]
Source	Natural Products > Araliaceae > Aralia

Molecular Weight	302.45
Formula	C20H30O2
CAS No.	127-27-5

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Pimaric acid from Aralia cordata has an inhibitory effect on TNF-α±-induced MMP-9 production and HASMC migration via down-regulated NF-κB and AP-1.Chem Biol Interact. 2012 Aug 30;199(2):112-9.

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Keywords

Pimaric acid 127-27-5 MAPK NF-Κb Proteases/Proteasome p38 MAPK MMP NF-κB inhibitor inhibit

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