Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Inecalcitol (TX 522) is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 537.00 | |
5 mg | In stock | $ 1,190.00 | |
10 mg | In stock | $ 1,590.00 | |
25 mg | In stock | $ 2,390.00 | |
50 mg | In stock | $ 3,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 1,490.00 |
Description | Inecalcitol (TX 522) is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM. |
Targets&IC50 | vitamin D3:0.53 nM(Kd) |
In vitro | A xenograft model of LNCaP cells was developed in immunodeficient mice treated with inecalcitol. The tumors of the diluent-treated control mice increased in size but those in the inecalcitol treatment group did not grow[1]. |
In vivo | Inecalcitol maximal tolerated dose (MTD) by intraperitoneal (i.p.) administration was 30 μg/mouse (1,300 μg/kg) three times per week, while we previously found that the MTD of 1,25(OH)(2) D(3) is 0.0625 μg/mouse; therefore, inecalcitol is 480 times less hypercalcemic than 1,25OH2 D3[1]. Inecalcitol inhibits androgen-responsive prostate cancer growth in vivo. |
Synonyms | TX 522, TX-522, TX522 |
Molecular Weight | 400.59 |
Formula | C26H40O3 |
CAS No. | 163217-09-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (137.3 mM)
You can also refer to dose conversion for different animals. More
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Inecalcitol 163217-09-2 Apoptosis anticancer antiproliferative TX 522 Vitamin D ETV1 Pim-1 Vitamin D receptor VDR VD/VDR TX-522 Inhibitor inhibit TX522 inhibitor