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Apoptosis Apoptosis Inecalcitol

Inecalcitol

Catalog No. T24166   CAS 163217-09-2
Synonyms: TX522, TX 522,

Inecalcitol is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.

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Inecalcitol, CAS 163217-09-2
Pack Size Availability Price/USD Quantity
1 mg In stock 587.00
5 mg In stock 1625.00
10 mg In stock 2697.00
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Purity 99.77%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Inecalcitol is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.
In vitro A xenograft model of LNCaP cells was developed in immunodeficient mice treated with inecalcitol. The tumors of the diluent-treated control mice increased in size but those in the inecalcitol treatment group did not grow[1].
Synonyms TX522 , TX 522 ,
Purity 99.77%
Molecular Weight 400.59
Formula C26H40O3
CAS No. 163217-09-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Ryoko Okamoto, et al. Inecalcitol, an analog of 1α,25(OH)(2) D(3) , induces growth arrest of androgen-dependent prostate cancer cells. Int J Cancer. 2012 May 15;130(10):2464-73. 2. Murray A, et al. Vitamin D receptor as a target for breast cancer therapy. Endocr Relat Cancer. 2017 Apr;24(4):181-195. 3. Suares A, et al. The proapoptotic protein Bim is up regulated by 1α,25-dihydroxyvitamin D3 and its receptor agonist in endothelial cells and transformed by viral GPCR associated to Kaposi sarcoma. Steroids. 2015 Oct;102:85-91. 4. Van Belle TL, et al. 1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients. PLoS One. 2014 Oct 3;9(10):e109194.

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ARRY 520 hydrochloride R1530 Thapsigargin Calcipotriol monohydrate Ercalcitriol Paricalcitol Acenocoumarol Juglanin

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