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Inecalcitol

Catalog No. T24166   CAS 163217-09-2
Synonyms: TX 522, TX-522, TX522

Inecalcitol (TX 522) is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.

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Inecalcitol Chemical Structure
Inecalcitol, CAS 163217-09-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 537.00
5 mg In stock $ 1,190.00
10 mg In stock $ 1,590.00
25 mg In stock $ 2,390.00
50 mg In stock $ 3,220.00
1 mL * 10 mM (in DMSO) In stock $ 1,490.00
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Purity: 99.77%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Inecalcitol (TX 522) is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.
Targets&IC50 vitamin D3:0.53 nM(Kd)
In vitro A xenograft model of LNCaP cells was developed in immunodeficient mice treated with inecalcitol. The tumors of the diluent-treated control mice increased in size but those in the inecalcitol treatment group did not grow[1].
In vivo Inecalcitol maximal tolerated dose (MTD) by intraperitoneal (i.p.) administration was 30 μg/mouse (1,300 μg/kg) three times per week, while we previously found that the MTD of 1,25(OH)(2) D(3) is 0.0625 μg/mouse; therefore, inecalcitol is 480 times less hypercalcemic than 1,25OH2 D3[1]. Inecalcitol inhibits androgen-responsive prostate cancer growth in vivo.
Synonyms TX 522, TX-522, TX522
Molecular Weight 400.59
Formula C26H40O3
CAS No. 163217-09-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (137.3 mM)

TargetMolReferences and Literature

1. Ryoko Okamoto, et al. Inecalcitol, an analog of 1α,25(OH)(2) D(3) , induces growth arrest of androgen-dependent prostate cancer cells. Int J Cancer. 2012 May 15;130(10):2464-73. 2. Murray A, et al. Vitamin D receptor as a target for breast cancer therapy. Endocr Relat Cancer. 2017 Apr;24(4):181-195. 3. Suares A, et al. The proapoptotic protein Bim is up regulated by 1α,25-dihydroxyvitamin D3 and its receptor agonist in endothelial cells and transformed by viral GPCR associated to Kaposi sarcoma. Steroids. 2015 Oct;102:85-91. 4. Van Belle TL, et al. 1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients. PLoS One. 2014 Oct 3;9(10):e109194.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Apoptosis Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library

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SC144 KW-2449 Bruceine D PD0166285 DB1976 Pictilisib dimethanesulfonate CHS-828 VTP50469

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Keywords

Inecalcitol 163217-09-2 Apoptosis anticancer antiproliferative TX 522 Vitamin D ETV1 Pim-1 Vitamin D receptor VDR VD/VDR TX-522 Inhibitor inhibit TX522 inhibitor

 

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