Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 72.00 | |
2 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 153.00 | |
10 mg | In stock | $ 217.00 | |
25 mg | In stock | $ 459.00 | |
50 mg | In stock | $ 673.00 | |
100 mg | In stock | $ 958.00 | |
500 mg | In stock | $ 1,930.00 |
Description | Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1]. |
In vitro | Pim-1/2 kinase inhibitor 1 (compound D14) (varying concentrations; 48 h) exhibits cytotoxicity to PC3 cells, with an IC of 11 μM [1]. Cell Cytotoxicity Assay [1] Cell Line: PC3 cells Concentration: varying concentrations Incubation Time: 48 h Result: Inhibited PC3 cells with an IC of 11 μM. |
Molecular Weight | 235.26 |
Formula | C11H9NO3S |
CAS No. | 6320-51-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225 mg/mL (956.4 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Pim-1/2 kinase inhibitor 1 6320-51-0 Chromatin/Epigenetic JAK/STAT signaling Pim 2,4 Thiazolidinedione, 5 p methoxybenzylidene 2,4Thiazolidinedione, 5pmethoxybenzylidene inhibitor inhibit