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Search Results for " osm "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T74733	OSM-SMI-10B
	OSM-SMI-10B, a derivative of OSM-SMI-10, effectively inhibits Oncostatin M (OSM)-induced STAT3 phosphorylation in cancer cells when co-incubated with OSM [1].
T3076	GLPG0634 analog	GLPG0634 analogue	Tyrosine Kinases , JAK
	GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.		Tyrosine Kinases , JAK
T77019	Garetosmab	REGN 2477	TGF-beta/Smad
	Garetosmab (REGN 2477) is A whole-human IgG4 monoclonal antibody that selectively inhibits activin A and acts on COVID-19 44. Garetosmab has potential anti-cancer activity and can be used to study ossifying fibrous dyspl...		TGF-beta/Smad
T11315	Fosmidomycin sodium salt	FR-31564 sodium salt	Antibiotic , Parasite
	Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative and Gram-positive bacteria.		Antibiotic , Parasite
T2277	Losmapimod	GSK-AHAB,GW856553X,GW856553,SB856553	p38 MAPK , Autophagy
	Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).		p38 MAPK , Autophagy
T12328	OSMI-4		Others
	OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells), which can be used to study OGT inhibition in different human cell lines.		Others
T77750	Rosmantuzumab	OMP-131R10	Others
	Rosmantuzumab (OMP-131R10) is a humanized monoclonal antibody against R-spondin 3 (RSPO3). Rosmantuzumab has potential antitumor activity and can be used to study advanced relapsed refractory solid tumors.		Others
T83646	(S)-OSMI 3	Ent-OSMI-3	Others
	(S)-OSMI 3 (Ent-OSMI-3) has anti-inflammatory and anti-tumour activity and can be used to study diabetes and neurodegenerative diseases.		Others
T12327	OSMI-3		Others
	OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease.		Others
T16409	OSMI-1		Others , Acyltransferase
	OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans.		Others , Acyltransferase
T63988	(Rac)-OSMI-1
	(Rac)-OSMI-1 is a racemate of OSMI-1. OSMI-1 is an inhibitor of O-GlcNAc transferase (OGT) (IC50: 2.7 μM). OSMI-1 inhibits protein O-linked N-acetylglucosaminoglycans (O-GlcNAcylation) in mammalian cell lines and does no...
T34391	Rosmarinine
	Rosmarinine is a non-toxic pyrrolizidine alkaloid.
T11314	Fosmanogepix	APX001,E1211	Others
	Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This...		Others
T72292	Tilpisertib fosmecarbil
	Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.
T125116	Diosmin Impurity 8
	Diosmin Impurity 8 is a useful organic compound for research related to life sciences and the catalog number is T125116.
T29474	6-Hydroxymyosmine
	6-Hydroxymyosmine is a Nornicotine metabolite.
T125437	14-Hydroxy-7-O-methylrosmanol
	14-Hydroxy-7-O-methylrosmanol is a useful organic compound for research related to life sciences. The catalog number is T125437 and the CAS number is 197649-67-5.
T12326	OSMI-2		Others
	OSMI-2 is a cell-permeable inhibitor of O-linked N-acetylglucosamine transferase (OGT).		Others
T125966	12-O-Acetylrosmarinine
	12-O-Acetylrosmarinine is a useful organic compound for research related to life sciences and the catalog number is T125966.
T125434	Rosmic acid
	Rosmic acid is a useful organic compound for research related to life sciences. The catalog number is T125434 and the CAS number is 197799-63-6.
T27350	Fosmetpantotenate	RE-024,RE024,RE 024
	Fosmetpantotenate, a immunomodulator, is used for treatment of Pantothenate Kinase Associated Neurodegeneration (PKAN).
T15774	Losmiprofen		Others
	Losmiprofen is a nonsteroidal compound of antiinflammatory.		Others
T123819	4'-O-Methyllucenin II (Diosmetin 6,8-di-C-glucoside)
	4'-O-Methyllucenin II (Diosmetin 6,8-di-C-glucoside) is a useful organic compound for research related to life sciences and the catalog number is T123819.
T126198	Rosmaquinone
	Rosmaquinone is a useful organic compound for research related to life sciences and the catalog number is T126198.
T125796	Osmanthuside H
	Osmanthuside H is a useful organic compound for research related to life sciences. The catalog number is T125796 and the CAS number is 149155-70-4.
T34830	Tetrofosmin	P 53,P53
	Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds.
T82045	Isecarosmab	M-6495
	Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a dissociation constant (K D) of 3.65 pM, exhibiting chondroprotective and anti-inflammatory properties. It has the capability to bind to albumin, whi...
T35205	Xylosmacin
	Xylosmacin is a biochemical.
T34029	Phosmet oxon	R-1571,R 1571,ENT 25707,ENT-25707,R1571
	Phosmet oxon is a toxic metabolite of phosmet, a phthalimide-derived, non-systemic, organophosphate insecticide used on plants and animals. It is mainly used on apple trees for control of codling moth, though it is also ...
T126193	Diosmin Impurity 5
	Diosmin Impurity 5 is a useful organic compound for research related to life sciences and the catalog number is T126193.
T76956	Vixarelimab	RG-6536,RO-7622888,KPL-716	Interleukin
	Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody with affinity for the beta chain of the OSM receptor and inhibition of IL-31 and OSM signaling.Vixarelimab can be used to study severe nodular ...		Interleukin
T74734	Truncated ADR58
	Truncated ADR58, derived by shortening full-length ADR58 from 71 bases to 31 bases, maintains comparable functional activity to its full-length counterpart. This compound acts as a potent and selective antagonist of huma...

Compounds

Synonym: GLPG0634 analogue

Target: Tyrosine Kinases, JAK

Garetosmab

T77019

Synonym: REGN 2477

Target: TGF-beta/Smad

Fosmidomycin sodium salt

T11315

Synonym: FR-31564 sodium salt

Target: Antibiotic, Parasite

Losmapimod

T2277

Synonym: GSK-AHAB,GW856553X,GW856553,SB856553

Target: p38 MAPK, Autophagy

Synonym: Ent-OSMI-3

Target: Others, Acyltransferase

Synonym: APX001,E1211

Target: Others

Tilpisertib fosmecarbil

14-Hydroxy-7-O-methylrosmanol

12-O-Acetylrosmarinine

Synonym: RE-024,RE024,RE 024

4'-O-Methyllucenin II (Diosmetin 6,8-di-C-glucoside)

Synonym: R-1571,R 1571,ENT 25707,ENT-25707,R1571

Synonym: RG-6536,RO-7622888,KPL-716

Cat No.	Product Name	Synonyms	Targets
TN1975	Neosmitilbin	Neoastilbin	Others
	Neosmitilbin (Neoastilbin) may have antioxidant and anti-inflammatory activities, it shows potent inhibition of lens aldose reductase.		Others
T7033	Rosmanol		Antioxidant , COX
	Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and a...		Antioxidant , COX
T4S0692	Diosmetin-7-O-β-D-glucopyranoside	Diosmetin-7-O-beta-D-glucopyranoside,Eridictiol	Antioxidant
	Diosmetin-7-O-β-D-glucopyranoside (Eridictiol) has antioxidant activity.		Antioxidant
T5728	OsMundacetone	4-(3,4-Dihydroxyphenyl)-3-buten-2-one	Apoptosis , Reactive Oxygen Species
	OsMundacetone (4-(3,4-Dihydroxyphenyl)-3-buten-2-one) is a natual product isolated from Rhizoma osmundae.		Apoptosis , Reactive Oxygen Species
T7671	Myosmine		Others , AChR
	Myosmine is a minor tobacco alkaloid that is structurally related to nicotine.		Others , AChR
T9135	Epirosmanol		Others
	Epirosmanol is a diterpenoid containing a lactone moiety. Epirosmanol is a very weakly basic (essentially neutral) compound (based on its pKa).		Others
T2P2898	Neodiosmin	Diosmetin-7-neohesperidoside,Diosmetin-7-O-neohesperidoside	Antioxidant
	1. Neodiosmin (Diosmetin-7-O-neohesperidoside) has poor aqueous solubility but exerts a good debittering effect and is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations...		Antioxidant
T1704	Diosmetin	Luteolin 4-methyl ether	P450 , Trk receptor
	Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.		P450 , Trk receptor
TN7057	Rosmarinate acid	(R)-rosmarinic acid,rosmarinic acid,Rosemary acid	MAO , Endogenous Metabolite , Transferase
	Rosmarinate acid(Rosemary acid) inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively		MAO , Endogenous Metabolite , Transferase
T2765	Rosmarinic acid	Labiatenic acid,Rosemary acid	Apoptosis , IκB/IKK , MAO , Endogenous Metabolite , Transferase , Monoamine Oxidase
	Rosmarinic acid (Labiatenic acid) is widely found in plants and has antioxidant, anti-inflammatory, and antibacterial activities. It inhibits MAO-A, MAO-B, and COMT with IC50 of 50.1, 184.6, and 26.7 μM respectively.
T0878	Diosmin	Venosmine,Diosmil,Barosmin	Aryl Hydrocarbon Receptor , Norepinephrine
	Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls.		Aryl Hydrocarbon Receptor , Norepinephrine
TN6784	Ethyl rosmarinate		MMP , Tyrosinase , Glucosidase
	ethyl rosmarinate inhibit the activity of tyrosinase, α-glucosidase, and matrix metalloproteinase-1 (MMP-1).		MMP , Tyrosinase , Glucosidase
TN1928	Methyl rosmarinate		MMP , Anti-infection , Tyrosinase
	Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmarinate shows antioxidative, and antifungal activities. It has...		MMP , Anti-infection , Tyrosinase
TN1334	7-Methoxyrosmanol	7-O-Methylrosmanol	cAMP
	7-Methoxyrosmanol (7-O-Methylrosmanol) can effectively suppress FSK-induced luciferase expression under the control of the CRE, PEPCK-C and G6Pase gene promoters, it may contribute to its antihyperglycemic activity.		cAMP
T11047	DiosMetin 7-O-β-D-Glucuronide		Others
	DiosMetin 7-O-β-D-Glucuronide is an antioxidant constituent in the fruits of Luffa cylindrical. The consumption of sponge gourds can supply some antioxidant constituents to the human body.		Others
TN5886	Thamnosmonin
	Thamnosmonin is a natural product from Citrus sinensis.
T80009	Osmanthuside B
	Osmanthuside B, isolated from Pseuderanthemum carruthersii (Seem.) Guill. var. atropurpureum (Bull.) Fosb, exhibits weak acetylcholinesterase inhibitory activity [1].
T83460	11-O-β-D-glucopyranosyl thamnosmonin
	11-O-β-D-glucopyranosyl thamnosmonin is a coumarin glucoside extractable from the roots of Angelica apaensis that exhibits weak inhibitory effects on rabbit platelet aggregation induced by PAF, AA, and ADP [1].
TN1329	7-Ethoxyrosmanol		Antifection
	7-Ethoxyrosmanol has cytotoxic and antimicrobial activities.		Antifection
TN6616	Diosmetinidin chloride
	Diosmetinidin chloride is a natural product for research related to life sciences. The catalog number is TN6616 and the CAS number is 64670-94-6.
TN1701	Glycosmisic acid		Others
	Glycosmisic acid is a natural product from Nauclea officinalis.		Others
TN3257	7beta-Methoxyrosmanol		Transferase
	7beta-Methoxyrosmanol inhibited acyl CoA:diacylglycerol acyltransferase (DGAT)1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM.		Transferase
TN1798	Isorosmanol		Beta Amyloid , AChR
	Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions and hyperpigmentation.		Beta Amyloid , AChR
TN6523	Rosmarinyl glucoside
	Rosmarinyl glucoside is a natural product for research related to life sciences. The catalog number is TN6523 and the CAS number is 910028-78-3.

Natural Products

Target: Antioxidant, COX

Diosmetin-7-O-β-D-glucopyranoside

T4S0692

Synonym: Diosmetin-7-O-beta-D-glucopyranoside,Eridictiol

Target: Antioxidant

OsMundacetone

T5728

Synonym: 4-(3,4-Dihydroxyphenyl)-3-buten-2-one

Target: Apoptosis, Reactive Oxygen Species

Synonym: Diosmetin-7-neohesperidoside,Diosmetin-7-O-neohesperidoside

Target: Antioxidant

Diosmetin

T1704

Synonym: Luteolin 4-methyl ether

Target: P450, Trk receptor

rosmarinate acid

TN7057

Synonym: (R)-rosmarinic acid,rosmarinic acid,Rosemary acid

Target: MAO, Endogenous Metabolite, Transferase

Rosmarinic acid

T2765

Synonym: Labiatenic acid,Rosemary acid

Target: Apoptosis, IκB/IKK, MAO, Endogenous Metabolite, Transferase, Monoamine Oxidase

Diosmin

T0878

Synonym: Venosmine,Diosmil,Barosmin

Target: Aryl Hydrocarbon Receptor, Norepinephrine

ethyl rosmarinate

TN6784

Synonym:

Target: MMP, Tyrosinase, Glucosidase

Methyl rosmarinate

TN1928

Synonym:

Target: MMP, Anti-infection, Tyrosinase

7-Methoxyrosmanol

TN1334

Synonym: 7-O-Methylrosmanol

Target: cAMP

DiosMetin 7-O-β-D-Glucuronide

11-O-β-D-glucopyranosyl thamnosmonin

Diosmetinidin chloride

7beta-Methoxyrosmanol

Target: Beta Amyloid, AChR

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01467	Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, ...
TMPK-00576	Oncostatin M/OSM Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	Oncostatin M/OSM Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 21.65 kDa and the accession number is A0A8I3Q5M1.
TMPK-00146	Oncostatin M/OSM Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Oncostatin M/OSM Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.1 kDa and the accession number is P13725.
TMPK-00145	Oncostatin M/OSM Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Oncostatin M/OSM Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.1 kDa and the accession number is P13725.
TMPY-00283	Oncostatin M/OSM Protein, Human, Recombinant	Human	HEK293 Cells
	Oncostatin M/OSM Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.16 kDa and the accession number is P13725.
TMPY-04062	Oncostatin M/OSM Protein, Mouse, Recombinant	Mouse	E. coli
	Oncostatin M/OSM Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20.7 kDa and the accession number is P53347.
TMPY-02627	Oncostatin M/OSM Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Oncostatin M/OSM Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22 kDa and the accession number is P53347.
TMPY-02364	Oncostatin M/OSM Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Oncostatin M/OSM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.6 kDa and the accession number is P13725.
TMPH-03345	Oncostatin M/OSM Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses only type II OSM receptor (heterodimers compos...
TMPH-02445	Oncostatin M/OSM Protein, Rhesus macaque, Recombinant (His)	Rhesus	Baculovirus Insect Cells
	Oncostatin M/OSM Protein, Rhesus macaque, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 28.8 kDa and the accession number is F7GF43.
TMPY-02335	OSMR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	OSMR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 83.7 kDa and the accession number is O70458-1.
TMPY-01305	OSMR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	OSMR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.6 kDa and the accession number is Q99650-1.
TMPH-00100	OSM34 Protein, Arabidopsis thaliana, Recombinant (His & Myc & SUMO)	Arabidopsis thaliana	E. coli
	OSM34 Protein, Arabidopsis thaliana, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 44.4 kDa and the accession number is P5070...
TMPH-03061	Osmotin Protein, Nicotiana tabacum, Recombinant (His & SUMO)	Nicotiana tabacum	E. coli
	Osmotin Protein, Nicotiana tabacum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 40.3 kDa and the accession number is P14170.
TMPY-01925	Nucleophosmin Protein, Human, Recombinant (His)	Human	E. coli
	Nucleophosmin Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P06748-1.
TMPH-02815	Nucleophosmin Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Nucleophosmin Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 48.6 kDa and the accession number is Q61937.
TMPK-00493	OSMR Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and prom...
TMPY-04259	Nucleophosmin Protein, Human, Recombinant (aa 2-294, His)	Human	E. coli
	Nucleophosmin Protein, Human, Recombinant (aa 2-294, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 34 kDa and the accession number is P06748-1.
TMPK-00571	OSMR Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and prom...
TMPK-01096	IL-31RA Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f...
TMPK-01113	IL-31RA Protein, Human, Recombinant (aa 20-519, hFc)	Human	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f...
TMPK-01114	IL-31RA Protein, Human, Recombinant (aa 20-519, His)	Human	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f...
TMPY-01783	SMOC1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	SPARC-related modular calcium-binding protein 1, also known as secreted modular calcium-binding protein 1 and SMOC1, is a member of the SPARC family. SMOC1 is widely expressed in many tissues with a strongest signal in o...
TMPJ-00081	CNTF Protein, Human, Recombinant	Human	E. coli
	Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species ...
TMPJ-00047	IL-31 Protein, Human, Recombinant	Human	E. coli
	Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes...