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Isorosmanol

Catalog No. TN1798 CAS 93780-80-4

Synonyms: 异迷迭香酚

Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions and hyperpigmentation.

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Isorosmanol, CAS 93780-80-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions and hyperpigmentation.

In vitro

The phenolic diterpenes isolated from the aerial parts of S. officinalis were tested for their effect on melanin biosynthesis in B16 melanoma cell lines. They were also tested for their ability to inhibit AChE using Ellman's method. Moreover, a molecular docking experiment was used to investigate the binding affinity of the isolated phenolic diterpenes to the amino acid residues at the active sites of AChE. Seven phenolic diterpenes-sageone, 12-methylcarnosol, carnosol, 7b-methoxyrosmanol, 7a-methoxyrosmanol, Isorosmanol and epirosmanol-were isolated from the methanolic extract of the aerial parts of S. officinalis. Isorosmanol showed a melanin-inhibiting activity as potent as that of arbutin. Compounds 7a-methoxyrosmanol and Isorosmanol inhibited AChE activity by 50% and 65%, respectively, at a concentration of 500 μM[1]

Synonyms	异迷迭香酚
Molecular Weight	346.423
Formula	C20H26O5
CAS No.	93780-80-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 90.0 mg/mL (259.8 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Acetylcholine esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis.Phytomedicine. 2016 Sep 15;23(10):1005-11.

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Keywords

Isorosmanol 93780-80-4 神经科学 AChR Beta Amyloid Inhibitor inhibitor inhibit

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