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OSMI-2

Catalog No. T12326 CAS 2260542-60-5

OSMI-2 is a cell-permeable inhibitor of O-linked N-acetylglucosamine transferase (OGT).

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OSMI-2, CAS 2260542-60-5

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,970.00
50 mg	8-10 weeks	$ 2,580.00
100 mg	8-10 weeks	$ 3,400.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

OSMI-2 is a cell-permeable inhibitor of O-linked N-acetylglucosamine transferase (OGT).

In vitro

In ?HCT116 cells,OSMI-2 ?treatment reduces O-GlcNAc levels at short treatment times (<8h).?However, O-GlcNAc levels begins to recover at longer treatment times with OSMI-2.?A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 in cells treated with OSMI-2 ?is observed.?Because OGT knockdown is known to decrease cell proliferation, the effects of OSMI-2 on cell growth in culture over 96h is also monitored.?Although there is no evidence of apoptosis, the reduced growth of cells over time is observed, consistent with the knockdown results.?A time course performed with 20 μM OSMI-2 shows reciprocal changes in the abundance of OGT and OGA, with a particularly large increase in OGT;?this may explain the recovery in O-GlcNAc levels with OSMI-2.?At 24h where O-GlcNAc levels fully recovered[1].

Molecular Weight	555.62
Formula	C26H25N3O7S2
CAS No.	2260542-60-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

OSMI-2 2260542-60-5 Others OSMI2 OSMI 2 inhibitor inhibit

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