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GLPG0634 analog

Catalog No. T3076 CAS 1206101-20-3

Synonyms: GLPG0634 analogue

GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.

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GLPG0634 analog, CAS 1206101-20-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 147.00
25 mg	In stock	$ 277.00
50 mg	In stock	$ 490.00
100 mg	In stock	$ 693.00
500 mg	In stock	$ 1,450.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 100%

Purity: 99.22%

Purity: 98.62%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
Targets&IC50	JAK2:28nM, JAK1:10nM, TYK2:116 nM, JAK3:810nM
Kinase Assay	EC50 values of the test compounds are calculated from serial dilution series ranging from 200 to 0.1 μM. Cells are seeded in 96-well plates at a density of 5,000 cells per well in 100 μL medium. The next day, 100 μL medium containing each test compound is added. Cells are incubated for 16 h, fixed and processed for automated microscopy. EC50 estimates are calculated using four-parameter log-logistic fit with the package drc[1].

Synonyms	GLPG0634 analogue
Molecular Weight	410.43
Formula	C23H18N6O2
CAS No.	1206101-20-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 199.8 mM

References and Literature

1. Van Rompaey L, et al. J Immunol. 2013, 191(7), 3568-3577.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tyrosine Kinase Inhibitor Library Angiogenesis related Compound Library Anti-Cancer Compound Library Epigenetics Compound Library Immunology/Inflammation Compound Library Covalent Inhibitor Library Anti-Obesity Compound Library Anti-Prostate Cancer Compound Library Anti-Aging Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GLPG0634 analog 1206101-20-3 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells Tyrosine Kinase/Adaptors JAK Tyrosine Kinases GLPG0634 Inhibitor AK-STAT GLPG-0634 GLPG0634 analogue Janus kinase inhibit Hela cell GLPG 0634 GLPG-0634 analog OSM/IL-lβ inhibitor

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