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Metabolism MAO Rosmarinic acid

Rosmarinic acid

Catalog No. T2765   CAS 20283-92-5
Synonyms: Labiatenic acid, Rosemary acid

Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive performance, Alzheimer′s disease prevention, kideney disease treatment, cardioprotection and c

Rosmarinic acid, CAS 20283-92-5
Pack Size Availability Price/USD Quantity
50 mg In stock 61.00
100 mg In stock 100.00
200 mg In stock 179.00
1 mL * 10 mM (in DMSO) In stock 59.00
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Purity 99.00%
Purity 99.47%
Purity 99.73%
Purity 98.19%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive performance, Alzheimer′s disease prevention, kideney disease treatment, cardioprotection and c
Targets&IC50 COMT : ic50 26.7μM ,   MAO-A : ic50 50.1μM ,   MAO-B : ic50 184.6μM ,   IKK β
Cell Research
Rosmarinic acid (RA) is dissolved in DMSO and stored, and then diluted with appropriate media before use[2]. Human keratinocytes (HaCaT cells) are treated with Rosmarinic acid (0.625, 1.25, 2.5, or 5 μM) and exposed to UVB radiation 1 h later. They are then incubated at 37°C for 48 h. At this time, MTT is added to each well to obtain a total reaction volume of 200 μL. After 4 h incubation, the supernatant is removed by aspiration. The formazan crystals in each well are dissolved in dimethyl sulfoxide (DMSO; 150 μL), and the absorbance at 540 nm is measured on a scanning multi-well spectrophotometer[2].
Animal Research
Animal Model: Mice
Synonyms Labiatenic acid , Rosemary acid
Purity 99.00%
Molecular Weight 360.33
Formula C18H16O8
CAS No. 20283-92-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 30 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Andrade JM, et al. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem Biol Interact. 2016 Jul 25;254:135-45. 2. Fernando PM, et al. Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells. Biomol Ther (Seoul). 2016 Jan;24(1):75-84. 3. Jin, B., Chung, K., Cheon, S., Lee, M., Hwang, S., & Noh Hwang, S. et al. (2017). Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation.?Scientific Reports,?7(1). doi: 10.1038/srep46252 4. Shim K S, Hwang Y H, Jang S A, et al. . Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice[J]. Nutrients.  2020, 12(7): 1927.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Natural Compound Library for HTS Anti-cancer Compound Library Clinical Compound Library Neuronal Signaling Compound Library Immunology/Inflammation Compound Library Selected Plant-sourced Compound Library Anti-Metabolism Disease Compound Library

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