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Search Result

Search Results for " cyp2c9 "

45

Compounds

10

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T63496 CYP2C9/CYP2C19-IN-1
CYP2C9/CYP2C19-IN-1 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.
T10423 AWZ1066S Parasite
AWZ1066S is a highly specific anti-Wolbachia drug candidate for the short-course treatment of filariasis (EC50: 2.5 nM in cell assay).
T25283 Cytochrome P450 2C9 Cyp2C9,Human cytochrome P450 2C9,Cytochrome P 450 2C9,S-Mephenytoin 4-hydroxylase
Cytochrome P450 2C9 is a cytochrome P-450 subtype that possesses specificity for acidic xenobiotics. It oxidizes a wide range of important clinical drugs under the categories of nonsteroidal anti-inflammatory agents, ant...
T0865 Ranitidine Hydrochloride AH19065 P450 , Antibacterial , Histamine Receptor
Ranitidine Hydrochloride (AH19065) is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enteroc...
T2088 APD668 APD 668 GPR , P450 , Potassium Channel
APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively.
T3610 Ranitidine HSDB 3925,Ranitidin P450 , Antibacterial , Histamine Receptor
Ranitidine (HSDB 3925) is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
T1274 Benzbromarone Desuric,Normurat,Urinorm Apoptosis , P450 , Xanthine Oxidase
Benzbromarone (Desuric) is a CYP2C9 inhibitor with Ki value of 19.3 nM.
T4567 Sulfaphenazole Plisulfan,Raziosulfa,Depocid,Depotsulfonamide P450 , Antibacterial
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1...
T10632 Bucolome Paramidin,5-Butyl-1-cyclohexylbarbituric acid,Paramidine,Bucolom,Bucolomum P450 , Immunology/Inflammation related
Bucolome (Paramidine) is a CYP2C9 inhibitor with uricosuric and anti-inflammatory activity.
T41291 MS-PPOH P450
MS-PPOH is a potent and selective inhibitor of cytochrome P450 (CYP) epoxygenase. MS-PPOH inhibits CYP2C8 and CYP2C9 with IC50s of 15 and 11 µM, respectively
T2753 Avasimibe PD-148515,CI-1011 P450 , Acyltransferase
Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz...
T77517 URAT1 inhibitor 7 OAT
URAT1 inhibitor 7 is a novel and potent inhibitor of the human uric acid transporter protein URAT1 (IC50:12 nM).URAT1 inhibitor 7 inhibits CYP2C9 with an IC50 of 4.2 μM.URAT1 inhibitor 7 can be used to study hyperuricemi...
T72617 Nampt activator-2 P450 , NAMPT
Nampt activator-2 is a NAMPT activator (EC50: 0.023 μM). Nampt activator-2 has an affinity for CYP2C9, 2D6, and 2C19 with affinity values of 0.060 μM, 0.41 μM, and 0.59 μM, respectively.Nampt activator-2 can be used in t...
T1149 Fenofibrate Procetofen,Lipanthyl,Lipantil P450 , PPAR , Autophagy
Fenofibrate (Lipanthyl) is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.
T4190 Ticlopidine PCR 5332,Ticlid ATPase , Adiponectin receptor
Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.
T4488 GSK-25 GSK25 ROCK , S6 Kinase , mTOR
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
T1415 Gemfibrozil CI-719,Jezil,Decrelip,Lopid P450 , Adrenergic Receptor , PPAR
Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi...
T35530 IHMT-PI3Kδ-372 IHMT-PI3Kδ-372 PI3K
IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease.
T11584 Hydroxy desmethyl Bosentan Ro 64-1056 Others
Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver.
T38911 Nav1.7-IN-8 Nav1.7-IN-8
Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP...
T13135 Tetrahydrocurcumin D6 HZIV 81-2 D6 Others
Tetrahydrocurcumin D6 is a deuterium labeled Tetrahydrocurcumin. Tetrahydrocurcumin displays inhibitory activity for CYP2C9 and CYP3A4.
T63495 CYP2C1/CYP2C19-IN-2
CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.
T36187 Celecoxib Carboxylic Acid
Celecoxib carboxylic acid is an inactive metabolite of the COX-2 inhibitor celecoxib .1,2It is formed from celecoxib primarily by the cytochrome P450 (CYP) isoform CYP2C9. 1.Liu, H., Huang, X., Shen, J., et al.Inhibitory...
T35641 Trans-hydroxy Glimepiride
trans-hydroxy Glimepiride is an active metabolite of the sulfonylurea glimepiride .1It is formed from glimepiride primarily in the liver by the cytochrome P450 (CYP) isoform CYP2C9. 1.Langtry, H.D., and Balfour, J.A.Glim...
T11187 EMT inhibitor-2 Others
EMT Inhibitor-2, targeting both CYP3A4 testosteron and CYP2C9, exhibits inhibitory effects with IC50 values of 49.72 and 5.54 μM, respectively. Furthermore, it effectively impedes the epithelial-mesenchymal transition (E...
T36769 10-hydroxy Warfarin
10-hydroxy Warfarin is a metabolite of (R)-warfarin .1It is formed from (R)-warfarin by the cytochrome P450 (CYP) isoform CYP3A4. 10-hydroxy Warfarin is an inhibitor of CYP2C9 (IC50= 1.6 μM), the enzyme that converts (S)...
T14040 4-Hydroxytolbutamide Hydroxytolbutamide Potassium Channel
4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].
T35640 Trans-carboxy Glimepiride
trans-carboxy Glimepiride is a metabolite of the sulfonylurea glimepiride .1It is formed from glimepiride in a two-step process mediated by the cytochrome P450 (CYP) isoform CYP2C9 and cytosolic enzymes. 1.Noh, K., Kim, ...
T62825 URAT1 inhibitor 2
URAT1 inhibitor 2 is an orally active inhibitor of URAT1 and CYP isozyme with IC50 values of 1.36 μM, 16.97 μM and 5.22 μM for URAT1-mediated 14C-UA uptake, CYP1A2 and CYP2C9, respectively, URAT1 inhibitor 2 is a promisi...
T70786 ML252
ML252 is a selective potassium channel inhibitor, specifically targeting the KCNQ2 channel (Kv7.2) with an IC50 value of 69 nM. Additionally, ML252 demonstrates inhibitory activity against Cytochrome P450 isoforms, inclu...
TMIH-0110 Benzbromarone-d5
Benzbromarone-d5 is a deuterated compound of Benzbromarone. Benzbromarone has a CAS number of 3562-84-3. Benzbromarone is a CYP2C9 inhibitor with Ki value of 19.3 nM.
T78590 Dibenzylfluorescein DBF
Dibenzylfluorescein (DBF), a fluorogenic probe (Fluorescent dye), serves as a substrate for various cytochrome P450 (CYP) isoforms, such as CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). It is commonly utilized ...
T36561 (3S)-hydroxy Quinidine
(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 be...
T35718 N-desmethyl Rosuvastatin (sodium salt hydrate)
N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) is...
T78925 HIV-1 inhibitor-58
HIV-1 Inhibitor-58 (Compound 10c) is a non-nucleoside reverse transcriptase inhibitor with broad-spectrum antiviral properties, effective against both wild-type strain IIIB and NNRTI-resistant strains like K103N and E138...
T71302 Norfluoxetine-d5 HCl
Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine b...
T62452 HIV-1 inhibitor-40
HIV-1 inhibitor-40 (Compound 4ab) is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) (EC50: 1.9 nM) with no significant acute toxicity in vivo. Orexin receptor antagonist is a highly sensitive inhibitor o...
TMIH-0095 Apigenin-d4
Apigenin-d4 is a deuterated compound of Apigenin. Apigenin has a CAS number of 520-36-5. Chamomile is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamo...
TMIH-0096 Apigenin-d6
Apigenin-d6 is a deuterated compound of Apigenin. Apigenin has a CAS number of 520-36-5. Chamomile is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamo...
T7788 2-Phenyl-2-(1-piperidinyl)propane Others
2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine
T35829 CC-90005
CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by I...
T10891 CRTH2-IN-1 Ramatroban analog P450
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
T10535 BI 653048 P450
BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor.
T10535L BI 653048 phosphate P450
BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).
T16097 MK-8318 Others
MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).

Compounds

CYP2C9/CYP2C19-IN-1
T63496
Synonym:
Target:
AWZ1066S
T10423
Synonym:
Target: Parasite
Cytochrome P450 2C9
T25283
Synonym: Cyp2C9,Human cytochrome P450 2C9,Cytochrome P 450 2C9,S-Mephenytoin 4-hydroxylase
Target:
Ranitidine Hydrochloride
T0865
Synonym: AH19065
Target: P450, Antibacterial, Histamine Receptor
APD668
T2088
Synonym: APD 668
Target: GPR, P450, Potassium Channel
Ranitidine
T3610
Synonym: HSDB 3925,Ranitidin
Target: P450, Antibacterial, Histamine Receptor
Benzbromarone
T1274
Synonym: Desuric,Normurat,Urinorm
Target: Apoptosis, P450, Xanthine Oxidase
Sulfaphenazole
T4567
Synonym: Plisulfan,Raziosulfa,Depocid,Depotsulfonamide
Target: P450, Antibacterial
Bucolome
T10632
Synonym: Paramidin,5-Butyl-1-cyclohexylbarbituric acid,Paramidine,Bucolom,Bucolomum
Target: P450, Immunology/Inflammation related
MS-PPOH
T41291
Synonym:
Target: P450
Avasimibe
T2753
Synonym: PD-148515,CI-1011
Target: P450, Acyltransferase
URAT1 inhibitor 7
T77517
Synonym:
Target: OAT
Nampt activator-2
T72617
Synonym:
Target: P450, NAMPT
Fenofibrate
T1149
Synonym: Procetofen,Lipanthyl,Lipantil
Target: P450, PPAR, Autophagy
Ticlopidine
T4190
Synonym: PCR 5332,Ticlid
Target: ATPase, Adiponectin receptor
GSK-25
T4488
Synonym: GSK25
Target: ROCK, S6 Kinase, mTOR
Gemfibrozil
T1415
Synonym: CI-719,Jezil,Decrelip,Lopid
Target: P450, Adrenergic Receptor, PPAR
IHMT-PI3Kδ-372
T35530
Synonym: IHMT-PI3Kδ-372
Target: PI3K
Hydroxy desmethyl Bosentan
T11584
Synonym: Ro 64-1056
Target: Others
Nav1.7-IN-8
T38911
Synonym: Nav1.7-IN-8
Target:
Tetrahydrocurcumin D6
T13135
Synonym: HZIV 81-2 D6
Target: Others
CYP2C1/CYP2C19-IN-2
T63495
Synonym:
Target:
Celecoxib Carboxylic Acid
T36187
Synonym:
Target:
trans-hydroxy Glimepiride
T35641
Synonym:
Target:
EMT inhibitor-2
T11187
Synonym:
Target: Others
10-hydroxy Warfarin
T36769
Synonym:
Target:
4-Hydroxytolbutamide
T14040
Synonym: Hydroxytolbutamide
Target: Potassium Channel
trans-carboxy Glimepiride
T35640
Synonym:
Target:
URAT1 inhibitor 2
T62825
Synonym:
Target:
ML252
T70786
Synonym:
Target:
Benzbromarone-d5
TMIH-0110
Synonym:
Target:
Dibenzylfluorescein
T78590
Synonym: DBF
Target:
(3S)-hydroxy Quinidine
T36561
Synonym:
Target:
N-desmethyl Rosuvastatin (sodium salt hydrate)
T35718
Synonym:
Target:
HIV-1 inhibitor-58
T78925
Synonym:
Target:
Norfluoxetine-d5 HCl
T71302
Synonym:
Target:
HIV-1 inhibitor-40
T62452
Synonym:
Target:
Apigenin-d4
TMIH-0095
Synonym:
Target:
Apigenin-d6
TMIH-0096
Synonym:
Target:
2-Phenyl-2-(1-piperidinyl)propane
T7788
Synonym:
Target: Others
CC-90005
T35829
Synonym:
Target:
CRTH2-IN-1
T10891
Synonym: Ramatroban analog
Target: P450
BI 653048
T10535
Synonym:
Target: P450
BI 653048 phosphate
T10535L
Synonym:
Target: P450
MK-8318
T16097
Synonym:
Target: Others
Cat No. Product Name Synonyms Targets
T6S1894 Linderane P450
1. Linderane was characterized as a mechanism-based inactivator of CYP2C9.
TQ0217 Gomisin G P450 , HIV Protease
Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
T3417 Amentoflavone Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin Apoptosis , P450 , Phospholipase , Reactive Oxygen Species , Opioid Receptor , COX , Antibacterial , RSV , Antifungal
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib...
T3818 Fraxinol Others , P450
Fraxinol is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 5, 7-dimethoxy-2h-chromen-2-one. It is generated by cyp1a2, cyp2a6, cyp2b6, cyp2c9, cyp2c19, and cyp2e1 enzymes via an...
T2878 Ginsenoside Rd Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII P450 , Calcium Channel , NF-κB , COX , Endogenous Metabolite
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
T3811 Ginsenoside C-K Ginsenoside compound K,Ginsenoside K P450 , cell cycle arrest , COX , NO Synthase
Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
T2175 Apigenin C.I. Natural Yellow 1,4',5,7-Trihydroxyflavone,NSC 83244,Apigenol,LY 080400 P450 , Autophagy
Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing qualities as a sedative, mild analgesic and sle...
T5S2360 Corydaline Corydalin,(+)-Corydaline P450 , Virus Protease , Opioid Receptor , AChE
1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastr...
T3662 Eleutheroside E NF-κB
Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the ...
T3735 Tetrahydrocurcumin Sabiwhite,Tetrahydrodiferuloylmethane,HZIV 81-2,Tetrahydro Curcumin P450 , Endogenous Metabolite , Autophagy
Tetrahydrocurcumin (HZIV 81-2), a major metabolite of curcumin, has strong antioxidant and cardioprotective properties.

Natural Products

Linderane
T6S1894
Synonym:
Target: P450
Gomisin G
TQ0217
Synonym:
Target: P450, HIV Protease
Amentoflavone
T3417
Synonym: Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin
Target: Apoptosis, P450, Phospholipase, Reactive Oxygen Species, Opioid Receptor, COX, Antibacterial, RSV, Antifungal
Fraxinol
T3818
Synonym:
Target: Others, P450
Ginsenoside Rd
T2878
Synonym: Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII
Target: P450, Calcium Channel, NF-κB, COX, Endogenous Metabolite
Ginsenoside C-K
T3811
Synonym: Ginsenoside compound K,Ginsenoside K
Target: P450, cell cycle arrest, COX, NO Synthase
Apigenin
T2175
Synonym: C.I. Natural Yellow 1,4',5,7-Trihydroxyflavone,NSC 83244,Apigenol,LY 080400
Target: P450, Autophagy
Corydaline
T5S2360
Synonym: Corydalin,(+)-Corydaline
Target: P450, Virus Protease, Opioid Receptor, AChE
Eleutheroside E
T3662
Synonym:
Target: NF-κB
Tetrahydrocurcumin
T3735
Synonym: Sabiwhite,Tetrahydrodiferuloylmethane,HZIV 81-2,Tetrahydro Curcumin
Target: P450, Endogenous Metabolite, Autophagy

Recombinant Proteins

Species：
Human (1)
Expression System：
E. coli (1)
Tag：
N-10xHis, C-Myc (1)
Cat No. Product Name Species Expression System
TMPH-01186 CYP2C9 Protein, Human, Recombinant (His & Myc) Human E. coli
CYP2C9 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
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