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4-Hydroxytolbutamide

Catalog No. T14040 CAS 5719-85-7

Synonyms: Hydroxytolbutamide

4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation <a href="/target/Potassium_Channel" style="display: inline; color: #c13a36">Potassium Channel</a> blocker and a sulfonylurea oral antidiabetic[1][2].

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4-Hydroxytolbutamide, CAS 5719-85-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].

Synonyms	Hydroxytolbutamide
Molecular Weight	286.35
Formula	C12H18N2O4S
CAS No.	5719-85-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71. 2. Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9.

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Keywords

4-Hydroxytolbutamide 5719-85-7 Membrane transporter/Ion channel Potassium Channel Hydroxytolbutamide 4Hydroxytolbutamide 4 Hydroxytolbutamide Inhibitor inhibitor inhibit

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