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IHMT-PI3Kδ-372

Catalog No. T35530 CAS 2429889-62-1

Synonyms: IHMT-PI3Kδ-372

IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease.

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IHMT-PI3Kδ-372, CAS 2429889-62-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 77.00
5 mg	In stock	$ 189.00
10 mg	In stock	$ 297.00
25 mg	In stock	$ 490.00
50 mg	In stock	$ 728.00
100 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 198.00

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Purity: 99.54%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease.
Targets&IC50	CYP2C9:2.7 μM (IC50), PI3Kδ:14 nM (IC50)
In vitro	In Raji cells, IHMT-PI3Kδ-372 (0.03-3 μM) inhibits PI3Kδ-mediated AKT T308 phosphorylation (EC50 = 67 nM).IHMT-PI3Kδ-372 moderately inhibits CYP2C9 (IC50 = 2.7 μM) and no apparently inhibits CYP1A2, CYP2B6, CYP2C19, and CYP3A4 (IC50s > 10 μM)[1].
In vivo	IHMT-PI3Kδ-372 (1-5 mg/kg; inhalation) improves lung function and reduced the inflammatory patterns characteristic of COPD with better forced expiratory volume in FEV1, FVC, and PEF. IHMT-PI3Kδ-372 dose-dependently decreases the inflammatory cell and reduces the abnormally high level of leukocytes including the alveolar macrophages, neutrophils, and lymphocytes. In rats, IHMT-PI3Kδ-372 (5 mg/kg; inhalation) displays a half-life of 2.3 h, low exposure of 66 ng/mL, and high clearance of 348.5 mL/min/kg in plasma and high exposure of 5599 ng/g (6 h after inhalation) in lung tissue[1].

Synonyms	IHMT-PI3Kδ-372
Molecular Weight	503.5
Formula	C26H23F2N7O2
CAS No.	2429889-62-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 37.8 mg/mL (75.1 mM), Sonication is recommended.

References and Literature

1. Feng Li, et al. Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1 H-pyrazolo[3,4- d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3 H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63(22):13973-13993.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Anti-Ovarian Cancer Compound Library Antioxidant Compound Library Metabolism Compound Library Anti-Cancer Compound Library Anti-Breast Cancer Compound Library Bioactive Compounds Library Max Antidepressant Compound Library Neuronal Differentiation Compound Library

Related Products

Related compounds with same targets

mTOR inhibitor 13 PI3K-IN-10 Brevianamide F (+)-Nortrachelogenin Pictilisib dimethanesulfonate Alpelisib 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one PF-4989216

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Keywords

IHMT-PI3Kδ-372 2429889-62-1 PI3K/Akt/mTOR signaling PI3K IHMT-PI3Kdelta-372 IHMTPI3Kδ372 IHMT-PI-3Kδ-372 IHMT PI3Kδ 372 inhibitor inhibit

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