Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (<2.2 uM at all isozymes tested).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
2 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 84.00 | |
10 mg | In stock | $ 119.00 | |
25 mg | In stock | $ 180.00 | |
50 mg | In stock | $ 286.00 | |
100 mg | In stock | $ 478.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 96.00 |
Description | GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
Targets&IC50 | mTOR (p70S6K):1000nM, RSK1:398 nM |
Synonyms | GSK25 |
Molecular Weight | 513.33 |
Formula | C24H16Cl2F2N6O |
CAS No. | 874119-56-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (116.88 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GSK-25 874119-56-9 Cell Cycle/Checkpoint Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling Stem Cells ROCK S6 Kinase mTOR Rho-associated kinase ROK Rho-associated protein kinase S6K bioavailable Ribosomal S6 Kinase (RSK) Rho-kinase Inhibitor p70S6K selective GSK25 pressure P450 inhibit blood orally GSK 25 inhibitor