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Amentoflavone

Amentoflavone
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Purity:99.22%
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Amentoflavone

Catalog No. T3417Cas No. 1617-53-4
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.
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Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
5 mg$61In Stock
10 mg$98In Stock
25 mg$166In Stock
50 mg$292In Stock
100 mg$446In Stock
1 mL x 10 mM (in DMSO)$72In Stock
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Product Introduction

Bioactivity
Description
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.
AliasDidemethyl-ginkgetin, Amenthoflavone, 3',8''-Biapigenin
Chemical Properties
Molecular Weight538.46
FormulaC30H18O10
Cas No.1617-53-4
Storage & Solubility Information
Storagekeep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 34 mg/mL(63.14 mM)
Chloroform, Dichloromethane, Ethyl Acetate: Soluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
100 mM0.0186 mL0.0929 mL0.1857 mL0.9286 mL

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