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Amentoflavone

Catalog No. T3417   CAS 1617-53-4
Synonyms: Amenthoflavone, 3',8''-Biapigenin, 穗花杉双黄酮, Didemethyl-ginkgetin

Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.

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Amentoflavone, CAS 1617-53-4
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.
Synonyms Amenthoflavone, 3',8''-Biapigenin, 穗花杉双黄酮, Didemethyl-ginkgetin
Molecular Weight 538.464
Formula C30H18O10
CAS No. 1617-53-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 34 mg/mL

Chloroform, Dichloromethane, Ethyl Acetate: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sakthivel KM, et al. Int Immunopharmacol. 2013 Nov;17(3):907-16. 2. Lee JS, et al. Phytother Res. 2013 May;27(5):713-20. 3. Yang Y, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(7):1035-8. 4. Zhang J, et al. Burns. 2014 Aug;40(5):922-9. 5. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin[J]. European Journal of Pharmaceutical Sciences. 2021: 105786.

Citations

1. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin. European Journal of Pharmaceutical Sciences. 2021: 105786.

Related compound libraries

This product is contained In the following compound libraries：
Anti-Cancer Compound Library Flavonoid Natural Product Library GPCR Compound Library HIF-1 Signaling Pathway Compound Library Anti-Cancer Metabolism Compound Library Anti-Cardiovascular Disease Compound Library Traditional Chinese Medicine Monomer Library Anti-Obesity Compound Library Neurotransmitter Receptor Compound Library Endocrinology-Hormone Compound Library

Related Products

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Protoanemonin (-)-α-Pinene Nanchangmycin Amikacin hydrate Sulfaclozine sodium Lenampicillin hydrochloride Cephradine monohydrate Cefodizime

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Keywords

Amentoflavone 1617-53-4 G蛋白偶联受体 NF-Kb信号通路 代谢 凋亡 免疫与炎症 内分泌与激素 神经科学 微生物学 Antibacterial Antifungal Apoptosis COX Opioid Receptor P450 Phospholipase Reactive Oxygen Species RSV Gamma-aminobutyric acid Receptor 3',8''-Biapigenin Inhibitor inhibit orally active U-87 MG cells C-FLIP γ-Aminobutyric acid Receptor Fungal MCL1 Respiratory syncytial virus anti-inflammatory GABA Receptor Amenthoflavone NF-?B antibacterial Didemethyl-ginkgetin Bacterial inhibitor

 

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