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Search Result

Search Results for " iglur "

Targets

iGluR NMDAR

83

Compounds

16

Natural Products

Cat No. Product Name Synonyms Targets
T14971 CIQ NMDAR
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D.
T12406 PEPA iGluR
PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
T16402 Org-26576 GluR , iGluR
Org-26576 is a positive allosteric modulator of the AMPA receptor.
T12234 NMDA-IN-1 NMDAR
NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).
T8920 Sepimostat iGluR
Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki v...
T20993 Memantine Others
Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by ...
T2362 QNZ46 NMDAR , iGluR
QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
T15623 JNJ-61432059 iGluR
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA1/γ-8).
T17293 ZL006 NMDAR , iGluR
ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
T9626 Cycloleucine NMDAR
Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic ef...
T7355 IC87201 Others , iGluR
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
T1897 MDL-29951 NMDAR , iGluR
MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
T4573 Cyclothiazide GluR
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).
T5522 NMDAR antagonist 1 Others , iGluR
NMDAR antagonist 1 is an orally active, NR2B-selective NMDAR antagonist.
TQ0289 LY450108 iGluR
LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.
TQ0233 Traxoprodil CP101606 NMDAR , iGluR
Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
T8458 CNQX disodium iGluR
CNQX disodium is a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures.
T4171 PEAQX NVP-AAM077 NMDAR , iGluR
PEAQX (NVP-AAM077)(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 nM).
T5385 Radiprodil RGH-896 NMDAR , iGluR
Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).
T22748 DQP 1105 NMDAR
DQP 1105 is a NMDA receptor antagonist.
T7870 TCN 201 TCN-201 NMDAR , iGluR
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T9177 BPAM344 iGluR
BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
T25196 BZAD01 BZAD-01,BZAD 01 NMDAR
BZAD01 is a selective NMDA NR1A/2B receptor antagonist.
T7579 1-BCP Piperonylic acid piperidide GluR , iGluR
1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.
T37734 AMPA receptor modulator-2 GluR
AMPA receptor modulator-2 (Example 134) is a AMPA receptor modulator, with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor[1]. pIC50 = -lgIC50. [1]. BERRY CYNTHIA G B (US), et al. AZABENZIMIDAZOLES AND THEIR USE AS AM...
T9723 GluR6 antagonist-1 Src
GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.
T7591 Coluracetam MKC-231 AChR , iGluR
Coluracetam (MKC-231)(MKC-231) is a Choline Uptake Enhancer.
T8450 TCN 213 TCN213 NMDAR
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
T0015 Mephenesin Cresoxydiol,Memphenesin,Mephedan,Decontractyl NMDAR , iGluR
Mephenesin (Cresoxydiol) is a centrally acting muscle relaxant with a short duration of action.
T8779 HBT1 GluR
HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate...
T1751 Eliprodil SL-820715 NMDAR , iGluR
Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has been used in trials studying the treatment of Pa...
T0426 Piracetam UCB-6215 GluR , iGluR
Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
T12187L Naspm trihydrochloride 1-Naphthylacetyl spermine trihydrochloride iGluR
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.
T9133 Caroverine hydrochloride Caroverine HCL GluR , NMDAR , iGluR
Caroverine hydrochloride (Caroverine HCL) is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, an...
T8459 DNQX disodium salt DNQX Disodium NMDAR , iGluR
DNQX disodium salt is a water-soluble form of selective antagonist of non-NMDA receptor
T3957 Farampator Org24448,CX-691 GluR , iGluR
Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.
T17179 Tulrampator CX-1632,S-47445 iGluR
Tulrampator (S-47445) is an orally bioavailable positive AMPAR with antidepressant effects.
T6259 Dizocilpine MK-801 NMDAR , iGluR
MK-801 (Dizocilpine (MK-801)) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
T7599 Sunifiram DM-235 iGluR
Sunifiram (DM-235) is a potent nootropic agent.
T22542 1-Aminocyclobutanecarboxylic acid ACBC NMDAR , iGluR
1-Aminocyclobutanecarboxylic acid (ACBC) is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
T7580 CX546 Autophagy , iGluR
CX546 is an AMPA receptor modulator. CX546 enhances cognitive function in rats. It has also been proposed as a treatment for schizophrenia.
T7304 DNQX FG 9041 GluR , iGluR
DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
T16977 Talampanel GYKI-53773,LY-300164 Apoptosis , GluR
Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models.
T4113 NBQX FG9202,NBQX disodium salt GluR , iGluR
NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
T0324 Isoxsuprine hydrochloride Duvadilan,Isolait Adrenergic Receptor , iGluR
Isoxsuprine hydrochloride (Isolait) is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
T13480 (S)-(-)-5-Fluorowillardiine (S)-5-Fluorowillardiine,(5S)-Fluorowillardiine iGluR
(S)-(-)-5-Fluorowillardiine ((S)-5-Fluorowillardiine) is an AMPA receptor-specific agonist
T1308 Orphenadrine hydrochloride Mebedrol,Mephenamin Sodium Channel , NMDAR , Norepinephrine , iGluR , Histamine Receptor
Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T12110 MRZ 2-514 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one NMDAR
MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.
T22733 DL-AP5 NMDAR
DL-AP5 is a NMDA antagonist.
T7108 Omberacetam SGS-111,Noopept,GVS-111 Others , iGluR
Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds.

Compounds

CIQ
T14971
Synonym:
Target: NMDAR
PEPA
T12406
Synonym:
Target: iGluR
Org-26576
T16402
Synonym:
Target: GluR, iGluR
NMDA-IN-1
T12234
Synonym:
Target: NMDAR
Sepimostat
T8920
Synonym:
Target: iGluR
Memantine
T20993
Synonym:
Target: Others
QNZ46
T2362
Synonym:
Target: NMDAR, iGluR
JNJ-61432059
T15623
Synonym:
Target: iGluR
ZL006
T17293
Synonym:
Target: NMDAR, iGluR
Cycloleucine
T9626
Synonym:
Target: NMDAR
IC87201
T7355
Synonym:
Target: Others, iGluR
MDL-29951
T1897
Synonym:
Target: NMDAR, iGluR
Cyclothiazide
T4573
Synonym:
Target: GluR
NMDAR antagonist 1
T5522
Synonym:
Target: Others, iGluR
LY450108
TQ0289
Synonym:
Target: iGluR
Traxoprodil
TQ0233
Synonym: CP101606
Target: NMDAR, iGluR
CNQX disodium
T8458
Synonym:
Target: iGluR
PEAQX
T4171
Synonym: NVP-AAM077
Target: NMDAR, iGluR
Radiprodil
T5385
Synonym: RGH-896
Target: NMDAR, iGluR
DQP 1105
T22748
Synonym:
Target: NMDAR
TCN 201
T7870
Synonym: TCN-201
Target: NMDAR, iGluR
BPAM344
T9177
Synonym:
Target: iGluR
BZAD01
T25196
Synonym: BZAD-01,BZAD 01
Target: NMDAR
1-BCP
T7579
Synonym: Piperonylic acid piperidide
Target: GluR, iGluR
AMPA receptor modulator-2
T37734
Synonym:
Target: GluR
GluR6 antagonist-1
T9723
Synonym:
Target: Src
Coluracetam
T7591
Synonym: MKC-231
Target: AChR, iGluR
TCN 213
T8450
Synonym: TCN213
Target: NMDAR
Mephenesin
T0015
Synonym: Cresoxydiol,Memphenesin,Mephedan,Decontractyl
Target: NMDAR, iGluR
HBT1
T8779
Synonym:
Target: GluR
Eliprodil
T1751
Synonym: SL-820715
Target: NMDAR, iGluR
Piracetam
T0426
Synonym: UCB-6215
Target: GluR, iGluR
Naspm trihydrochloride
T12187L
Synonym: 1-Naphthylacetyl spermine trihydrochloride
Target: iGluR
Caroverine hydrochloride
T9133
Synonym: Caroverine HCL
Target: GluR, NMDAR, iGluR
DNQX disodium salt
T8459
Synonym: DNQX Disodium
Target: NMDAR, iGluR
Farampator
T3957
Synonym: Org24448,CX-691
Target: GluR, iGluR
Tulrampator
T17179
Synonym: CX-1632,S-47445
Target: iGluR
Dizocilpine
T6259
Synonym: MK-801
Target: NMDAR, iGluR
Sunifiram
T7599
Synonym: DM-235
Target: iGluR
1-Aminocyclobutanecarboxylic acid
T22542
Synonym: ACBC
Target: NMDAR, iGluR
CX546
T7580
Synonym:
Target: Autophagy, iGluR
DNQX
T7304
Synonym: FG 9041
Target: GluR, iGluR
Talampanel
T16977
Synonym: GYKI-53773,LY-300164
Target: Apoptosis, GluR
NBQX
T4113
Synonym: FG9202,NBQX disodium salt
Target: GluR, iGluR
Isoxsuprine hydrochloride
T0324
Synonym: Duvadilan,Isolait
Target: Adrenergic Receptor, iGluR
(S)-(-)-5-Fluorowillardiine
T13480
Synonym: (S)-5-Fluorowillardiine,(5S)-Fluorowillardiine
Target: iGluR
Orphenadrine hydrochloride
T1308
Synonym: Mebedrol,Mephenamin
Target: Sodium Channel, NMDAR, Norepinephrine, iGluR, Histamine Receptor
MRZ 2-514
T12110
Synonym: 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one
Target: NMDAR
DL-AP5
T22733
Synonym:
Target: NMDAR
Omberacetam
T7108
Synonym: SGS-111,Noopept,GVS-111
Target: Others, iGluR
1 2
Cat No. Product Name Synonyms Targets
T1186 Ifenprodil Tartrate Potassium Channel , NMDAR , iGluR
Ifenprodil is a selective NMDA receptor (glutamate) antagonist.
T2S2264 Linalool Linalol,(±)-Linalool,Phantol Apoptosis , IL Receptor , TNF , Endogenous Metabolite , iGluR
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury th...
T8394 D-Serine (R)-Serine Endogenous Metabolite , NMDAR , iGluR
D-Serine ((R)-Serine) is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.
T3379 Decanoic Acid Decoic acid,CAPRIC ACID,Caprynic acid GluR , iGluR
Decanoic Acid (Caprynic acid) acts as a non-competitive AMPA receptor antagonist.
TQ0027 Transcrocetinate disodium Disodium trans-crocetinate NMDAR , iGluR
Transcrocetinate disodium (Disodium trans-crocetinate), extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
T4096 Quinolinic acid pyridine-2,3-dicarboxylic acid,QUIN Endogenous Metabolite , NMDAR , iGluR
Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.
T6608 NMDA N-Methyl-D-aspartic acid Endogenous Metabolite , NMDAR , iGluR
N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA (N-Methyl-D-aspartic acid) receptor subtype of glutamate receptors.
T4S0171 Transcrocetin trans-Crocetin,8,8'-Diapocarotenedioic Acid,Crocetin Others , Endogenous Metabolite , iGluR
Transcrocetin (8,8'-Diapocarotenedioic Acid) is a singlet oxygen quencher.
T1589 D-Cycloserine RO-1-9213 Others , Antibacterial , Antibiotic , iGluR
D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with other antituberculosis agents.
T2O2728 Glycine 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll MT Receptor , Endogenous Metabolite , iGluR
glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
T3026 (-)-Huperzine A HupA,Huperzine A Apoptosis , AChR , AChE , iGluR
(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the tr...
T2A2497 L-Glutamic acid (S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,glutacid,Glutaminol Apoptosis , Ferroptosis , Endogenous Metabolite , iGluR
L-Glutamic acid (Glutaminol) acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
T4885 (-)-Aspartic acid (R)-Aspartic acid,Asp,D-(-)-Aspartic acid,Aminosuccinic acid,asparagic acid,L-Homoproline,D-Aspartic acid Endogenous Metabolite , NMDAR , iGluR
(-)-Aspartic acid (L-Homoproline) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA receptor.
T6871 L-Glutamic acid monosodium salt Monosodium glutamate,Glutacyl,Glutavene,Ajinomoto,MSG Apoptosis , Ferroptosis , GluR , iGluR
L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.
T0948L Corticosterone 17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants) Glucocorticoid Receptor , Endogenous Metabolite
Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stres...
T3377 L-Phenylalanine (S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine Calcium Channel , Endogenous Metabolite , iGluR
L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.

Natural Products

Ifenprodil Tartrate
T1186
Synonym:
Target: Potassium Channel, NMDAR, iGluR
Linalool
T2S2264
Synonym: Linalol,(±)-Linalool,Phantol
Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR
D-Serine
T8394
Synonym: (R)-Serine
Target: Endogenous Metabolite, NMDAR, iGluR
Decanoic Acid
T3379
Synonym: Decoic acid,CAPRIC ACID,Caprynic acid
Target: GluR, iGluR
Transcrocetinate disodium
TQ0027
Synonym: Disodium trans-crocetinate
Target: NMDAR, iGluR
Quinolinic acid
T4096
Synonym: pyridine-2,3-dicarboxylic acid,QUIN
Target: Endogenous Metabolite, NMDAR, iGluR
NMDA
T6608
Synonym: N-Methyl-D-aspartic acid
Target: Endogenous Metabolite, NMDAR, iGluR
Transcrocetin
T4S0171
Synonym: trans-Crocetin,8,8'-Diapocarotenedioic Acid,Crocetin
Target: Others, Endogenous Metabolite, iGluR
D-Cycloserine
T1589
Synonym: RO-1-9213
Target: Others, Antibacterial, Antibiotic, iGluR
glycine
T2O2728
Synonym: 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll
Target: MT Receptor, Endogenous Metabolite, iGluR
(-)-Huperzine A
T3026
Synonym: HupA,Huperzine A
Target: Apoptosis, AChR, AChE, iGluR
L-Glutamic acid
T2A2497
Synonym: (S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,glutacid,Glutaminol
Target: Apoptosis, Ferroptosis, Endogenous Metabolite, iGluR
(-)-Aspartic acid
T4885
Synonym: (R)-Aspartic acid,Asp,D-(-)-Aspartic acid,Aminosuccinic acid,asparagic acid,L-Homoproline,D-Aspartic acid
Target: Endogenous Metabolite, NMDAR, iGluR
L-Glutamic acid monosodium salt
T6871
Synonym: Monosodium glutamate,Glutacyl,Glutavene,Ajinomoto,MSG
Target: Apoptosis, Ferroptosis, GluR, iGluR
Corticosterone
T0948L
Synonym: 17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants)
Target: Glucocorticoid Receptor, Endogenous Metabolite
L-Phenylalanine
T3377
Synonym: (S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine
Target: Calcium Channel, Endogenous Metabolite, iGluR
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