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Org-26576

Catalog No. T16402 CAS 1026791-61-6

Org-26576 is a positive allosteric modulator of the AMPA receptor.

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Org-26576, CAS 1026791-61-6

Pack Size	Availability	Price/USD
2 mg	In stock	$ 41.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 107.00
25 mg	In stock	$ 177.00
50 mg	In stock	$ 256.00
100 mg	In stock	$ 450.00
1 mL * 10 mM (in DMSO)	In stock	$ 71.00

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Purity: 99.94%

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Description	Org-26576 is a positive allosteric modulator of the AMPA receptor.
In vitro	Org-26576 shows selectivity for AMPA receptors when tested at 10 μM against >60 molecular targets including G-Protein Coupled Receptors, ion channels, and kinases. Org-26576 represents structurally a distinct chemical series derived from the first generation ampakine CX516 and shows 10-30 fold greater potency when compared to CX516 in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 μM in rat hippocampal primary cultured neurons [1].
In vivo	Org-26576 (Chronic administration) increases progenitor cell proliferation in the dentate gyrus (approximately 40%) and in the prelimbic cortex (approximately 35%) at the 10-mg/kg dosage. Cells born in response to chronic Org-26576 in dentate gyrus show increased rates of survival (approximately 30%) with the majority of surviving cells expressing a neuronal phenotype. Org-26576 (1 mg/kg) produces obviously enhances the anteroventral and laterodorsal thalamus, cingulate cortex, dentate gyrus, and CA3 subfield of the hippocampus in mice. AMPA receptor potentiation by Org-26576 exerts a positive modulatory influence on brain-derived neurotrophic factor (BDNF) expression during ongoing neuronal activity. Total BDNF mRNA levels are significantly increased in the hippocampus of animals exposed to the combination of Org-26576 and stress[1][2][3].

Molecular Weight	204.23
Formula	C11H12N2O2
CAS No.	1026791-61-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (122.41 mM), Sonification is recommended.

References and Literature

1. Jordan GR, et al. Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography. Neuropharmacology. 2005 Aug;49(2):254-64. 2. Su XW, et al. Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus. Psychopharmacology (Berl). 2009 Oct;206(2):215-22. 3. Fumagalli F, et al. The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus. Pharmacol Res. 2012 Feb;65(2):176-81.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Ion Channel Inhibitor Library Bioactive Compound Library Anti-Alzheimer's Disease Compound Library ReFRAME Related Library Anti-Cancer Compound Library Bioactive Compounds Library Max

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Keywords

Org-26576 1026791-61-6 Membrane transporter/Ion channel Neuroscience iGluR GluR inhibit Inhibitor Org 26576 Ionotropic glutamate receptors Org26576 inhibitor

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