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Memantine

Catalog No. T20993 CAS 19982-08-2

Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors.

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Memantine, CAS 19982-08-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 70.00
25 mg	In stock	$ 114.00
50 mg	In stock	$ 167.00
100 mg	In stock	$ 248.00
500 mg	In stock	$ 535.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	179.3
Formula	C12H21N
CAS No.	19982-08-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (278.86 mM)

References and Literature

1. Chen R, Chan PT, Chu H, Lin YC, Chang PC, Chen CY, Chou KR. Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis. PLoS One. 2017 Aug 21;12(8):e0183586. 2. Deardorff WJ, Grossberg GT. A fixed-dose combination of memantine extended-release and donepezil in the treatment of moderate-to-severe Alzheimer's disease. Drug Des Devel Ther. 2016 Oct 3;10:3267-3279. eCollection 2016. Review. PubMed PMID: 27757016; PubMed Central PMCID: PMC5055113. 3. Greig SL. Memantine ER/Donepezil: A Review in Alzheimer's Disease. CNS Drugs. 2015 Nov;29(11):963-70. doi: 10.1007/s40263-015-0287-Review. PubMed PMID: 26519339. 4. Matsunaga S, Kishi T, Iwata N. Memantine monotherapy for Alzheimer's disease: a systematic review and meta-analysis. PLoS One. 2015 Apr 10;10(4):e0123289. doi: 10.1371/journal.pone.0123289. eCollection 201Review. PubMed PMID: 25860130; PubMed Central PMCID: PMC4393306.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Approved Drug Library EMA Approved Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Bioactive Compound Library Orally Active Compound Library Pediatric Drug Library Anti-Alzheimer's Disease Compound Library Anti-Lung Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Memantine 19982-08-2 Others iGluR LTP Alzheimer's Inhibitor disease inhibit Ionotropic glutamate receptors depressive hippocampal inhibitor

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