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Corticosterone

Catalog No. T0948L   CAS 50-22-6
Synonyms: 17-Deoxycortisol, 11β,21-Dihydroxyprogesterone, Kendall's compound B, Corticosterone (From plants)

Corticosterone (Kendall's compound B) is a sensitive inhibitor of monoamine transport.

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Corticosterone Chemical Structure
Corticosterone, CAS 50-22-6
Pack Size Availability Price/USD Quantity
50 mg In stock $ 41.00
100 mg In stock $ 57.00
200 mg In stock $ 83.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Purity: 99.89%
Purity: 99.82%
Purity: 99.52%
Purity: 99.46%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Corticosterone (Kendall's compound B) is a sensitive inhibitor of monoamine transport.
In vitro Corticosterone, via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane. It enhances AMPAR-mediated miniature excitatory postsynaptic current (mEPSC) amplitude and surface expression of GluR1 and GluR2 subunits in hippocampal neurons, increases the surface mobility and synaptic content of AMPAR GluR2 subunits, and enhances L-type calcium currents in CA1 pyramidal neurons. Corticosterone operates through mineralocorticoid receptors and glucocorticoid receptors, both of which belong to the family of nuclear receptors that bind to response elements in the DNA, thus modifying the activity of responsive genes[1].
In vivo Corticosterone plays an important role in regulating neuronal functions of the limbic system. After stress, the level of stress hormones such as corticosterone is markedly increased. Corticosterone exerts a time- and region-specific action on cellular physiology of limbic neurons[1].
Cell Research HEK293 cells are grown in 6-cm dishes in 10% fetal bovine serum DMEM medium. When cells are 90% confluent, the medium is changed to 0.5% fetal bovine serum DMEM to limit serum-induced up-regulation of SGK. For in vitro phosphorylation analysis, the following approach is used. HEK293 cells are transfected with or without SGK1 small interfering RNA. One day after transfection, cells are treated without or with 100 nM corticosterone for 30 min, washed, and maintained in 0.5% fetal bovine serum DMEM for 1.5 h. Then cells are lysed in the CytoBuster protein extraction reagent containing protease inhibitors. Cell lysates are centrifuged at 16,000 × g at 4 °C for 20 min. The supernatants (40 μl, ~50 μg of total protein) are incubated with 1 μg of purified GST fusion protein of wild-type GDI or its mutants for 30 min at 30 °C in the reaction buffer (30 mM HEPES, pH 7.5, 10 mM MgCl2, 30 μM ATP, 1 μCi of [γ-32P]ATP, 100 nM calyculin, 1 μM okadaic acid). SDS-PAGE is carried out, and phosphorylated GDI is visualized with autoradiography.(Only for Reference)
Synonyms 17-Deoxycortisol, 11β,21-Dihydroxyprogesterone, Kendall's compound B, Corticosterone (From plants)
Molecular Weight 346.46
Formula C21H30O4
CAS No. 50-22-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 3.5 mg/mL (10 mM)

DMSO: 34.7 mg/mL (100 mM)

TargetMolReferences and Literature

1. Liu W, et al. J Biol Chem. 2010, 285(9):6101-8.

TargetMolCitations

1. Li C, Wu H, Na H S T, et al. Neuronal-Microglial Liver X receptor β Activating Decrease Neuroinflammation and Chronic Stress-induced Depression-Related Behavior in Mice. Brain Research. 2022: 148112. 2. Zhou Y, Zhou L, Jin W, et al.Chronic Allergen Exposure Contributes to Steroid Resistance via Increased Phosphorylation of Glucocorticoid Receptors S226 and p38 MAPK in a Mouse Model of Asthma.Iranian Journal of Allergy, Asthma and Immunology.2023: 1-10. 3. Wang G, Cao L, Li S, et al.Corticosterone Impairs Hippocampal Neurogenesis and Behaviors through p21-Mediated ROS Accumulation.Biomolecules.2024, 14(3): 268.

Related compound libraries

This product is contained In the following compound libraries:
Human Endogenous Metabolite Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Natural Product Library Bioactive Lipid Compound Library Endocrinology-Hormone Compound Library Covalent Natural Product Library Inhibitor Library Bioactive Compounds Library Max RO5 Drug-like Natural Product Library

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Keywords

Corticosterone 50-22-6 Endocrinology/Hormones Metabolism Glucocorticoid Receptor Endogenous Metabolite 17-Deoxycortisol 11β,21-Dihydroxyprogesterone ethanol intake Ionotropic glutamate receptors MHC class II BDNF 11b,21-Dihydroxyprogesterone BMDC inhibit immunosuppression Kendall's compound B B7.2 11beta,21-Dihydroxyprogesterone Inhibitor Corticosterone (From plants) B7.1 iGluR CD40 inhibitor

 

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