Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 84.00 | |
10 mg | In stock | $ 139.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 537.00 | |
100 mg | In stock | $ 775.00 | |
500 mg | In stock | $ 1,590.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a. |
In vitro | BPAM344 potentiated glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreased desensitization kinetics (from 5.5 to 775 ms). BPAM521 potentiated the recorded peak current amplitude of GluK2a 12-fold at a concentration of 300 μM with an EC50 value of 159 μM. BPAM344 (100 μM) potentiated the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold)[1]. |
Molecular Weight | 242.27 |
Formula | C10H11FN2O2S |
CAS No. | 1204572-55-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (227.02 mM)
You can also refer to dose conversion for different animals. More
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BPAM344 1204572-55-3 Membrane transporter/Ion channel Neuroscience iGluR Ionotropic glutamate receptors GluK3a PAM Inhibitor KAR GluK1b BPAM 344 GluK2a inhibit BPAM-344 inhibitor